Objective
In the last decades, the progress in medicine have contributed to extend human lifespan considerably. Unfortunately, this aging of populations gives rise to the increased appearance of degenerative diseases and cancers, and therefore represents a critical problem for public health. During embryonic development, cellular proliferation is an essential process that is required to generate all the tissues and organs that contribute to the adult organism. However, alterations in the molecular mechanisms regulating this fundamental process can drive developmental defects and tumors. Cellular fail-safe systems evolved to prevent these events to happen. One of them is the natural shortening of chromosome ends, termed the telomeres. This “molecular clock” prevents cells from proliferating if their telomeres become critically short, which could lead to chromosomal alterations. This mechanism is responsible for cellular aging in Human. Unfortunately, cancer cells can bypass this process through the activation of telomere maintenance mechanism allowing for virtually unlimited proliferation. Interestingly, such maintenance mechanisms naturally occur during early embryonic development. The proposed research is aimed at understanding how telomeres are regulated in this system and under a physiological context. My expertise in mouse embryonic work associated with the competences in telomere biology of the host laboratory of Dr. Jerome Déjardin will likely be a suitable combination to answer these questions. On the long term, these researches could lead to the discovery of key factors regulating telomere maintenance. Finally, as the suppression of telomere length maintenance inhibits cell growth, the present proposal could contribute to the development of new treatments against cancer or precocious aging.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences health sciences public health
- medical and health sciences medical biotechnology cells technologies stem cells
- medical and health sciences clinical medicine oncology
- medical and health sciences clinical medicine embryology
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
75794 PARIS
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.