Objective
The nervous system contains thousands of morphologically and physiologically different neuronal cell types, organized in distinct circuits. Information processed by the retina is streamed into more than 10 retino-recipient brain regions through approximately 20 distinct visual channels, originating in retinal ganglion cell types. One key feature of visual processing is significant convergence and divergence of retinal ganglion cell type inputs to different brain regions. The objective of this proposal is to understand the relevance of this convergence and divergence of visual pathways. Recently, we have identified several Cre transgenic mouse lines in which labeled ganglion cells show a mosaic-like distribution pattern of ganglion cell bodies in the retina and restricted axonal projections in the retino-recipient layers of the lateral geniculate nucleus, superior colliculus, and accessory optic system. Utilizing these new cell-type-labeled mouse lines, we will first characterize the morphological and physiological properties of Cre-expressing cell types. Next, we will silence or activate the synaptic release of individual cell types at a selective terminal region, such as the visual cortex and superior colliculus, using pharmacogenetic and optogenetic tools, and test their effects on light responses by in-vivo two-photon imaging. Finally, we will investigate the effects of silencing and activation of individual synaptic terminals on behaviors that it has been proposed are mediated by specific visual pathways: visual discrimination mediated by the retino-geniculate pathway; innate escape and approach behavior by the superior colliculus; and visually evoked compensatory head and eye movements by the accessory optic pathway. We aim to link, for the first time, individual pathways of ganglion cell type function with visual computation and behavior in order to gain mechanistic insights into how neuronal circuits are functionally organized in our brain.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine ophthalmology glaucoma
- social sciences sociology social issues social inequalities
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF)
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
8000 Aarhus C
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.