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Therapy for regeneration of Heart Muscle based on targeted delivery of exosomes

Objective

Given the poor regenerative potential of the adult heart after heart failure (HF), therapies capable of contributing for cardioprotection and cardio-regeneration are of great need. Recent advances in pharmacologic therapy and stem cells are currently not enough to address HF. The hypothesis of this project is that exosomes, nanovesicles secreted by cells may be a potential therapy for HF. Exosomes may offer advantages relatively to cell-based therapies regarding efficacy (does not require engraftment and survival), processing and cost. The main objective of the current project is to develop an effective strategy to deliver exosomes by intravenous (IV) injection into the heart (targeting) and to maximize exosome regenerative potential (bioactivity). Therefore, the project aims to develop a non-cellular-based therapy to regenerate the heart after infarction based on the targeted delivery of exosomes. Undertaking this research along with formal training and mentoring will enhance my academic profile, scientific experience, and content expertise in nanobiotechnology, to enable me to develop into an independent, leading researcher. The proposed research contributes to the EU priority of addressing the societal challenge of improving lifelong health and wellbeing of all.

Field of science

  • /medical and health sciences/medical biotechnology/cells technologies/stem cells

Call for proposal

H2020-MSCA-IF-2016
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

CENTRO DE NEUROCIENCIAS E BIOLOGIACELULAR ASSOCIACAO
Address
Universidade De Coimbra Largo Marques De Pombal
3004 517 Coimbra
Portugal
Activity type
Research Organisations
EU contribution
€ 160 635,60