Objective
Colour vision is critical animals to navigate their environment. Here, two or more spectrally distinct cone-photoreceptor types are needed in the retina which must be postsynaptically combined to extract contrasts in wavelength.
Bipolar cells make selective connections with distinct cone types at the first synaptic layer of the retina and cone-signal integration by bipolar cells lays the foundation for vertebrate colour vision. However, how bipolar cells form connections with selective cone types and achieve functional integration of these inputs to extract chromatic signals during development remains poorly understood. We will focus on zebrafish that has robust colour vision and study the roles of cone inputs and composition in establishing bipolar cell chromatic wiring and function. We will use a multidisciplinary approach spanning genetic methods, anatomical analysis, physiological recordings and statistical modelling. Drawing on existing genetic tools and marker lines established by the applicant, we will focus on two genetically targeted bipolar cell types: one that is cone-selective and one that is cone-unselective. First, we will use in vivo time-lapse imaging to study how these bipolar cells formation dendritic contacts with cones during development. Next, we will use two-photon functional imaging of light-driven synaptic release from cones as well as both dendritic and axonal imaging in bipolar cells to study how chromatically distinct signals are functionally integrated. Finally, using further lines already established by the applicant, we will genetically silence or ablate individual cone types to study how functional integration and wiring formation are regulated by the activity or availability of cones. These studies will gain insight into the strategies to encode chromatic information in parallel pathways of the retina and thus advance our understanding in the role of colour vision circuits in driving animal behaviour.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- medical and health sciences clinical medicine ophthalmology
- natural sciences biological sciences biological behavioural sciences ethology
- natural sciences biological sciences microbiology
- natural sciences computer and information sciences data science data processing
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
BN1 9RH BRIGHTON
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.