Objective
Tumour-derived circulating exosomes are an ideal, easily accessible reservoir of cancer biomarkers to assess disease processes. Quantitatively pinpointing exosome tumour markers, a clinical field of an unmet need is appealing, yet challenging. The main objectives of the proposal are to develop an integrated dual-signalling exosome biosensor (ExoSensor) for rapid and specific detection of GPC1+ exosomes and fabricate a 3D-printed portable prototype for POCT diagnosis of pancreatic cancer, offering an universal technology for clinical cancer diagnosis through quantitatively monitoring the protein marker of cancer-derived exosomes, in a simple way. The novelty resides in creatively achieving accurate, sensitive, and simultaneous detection of exosomes by integrating two synergetic methods (optical and electrochemical) on one single nanosensing platform, avoiding false positive/negative results to the utmost and ensuring the reliability of tests. This European Fellowship at Kings College London will provide the researcher with advanced technical training in molecular biology, exosome, cancer cell and animal handling, analytical chemistry and microscopy and imaging techniques, as well as academic mentoring in research management. A secondment to Cardiff University will seek and confirm the best possible biomarker(s). Another secondment to the industrial partner AstraZeneca Ltd will offer access to various exosomes research (diagnostics, toxicology and therapeutics) and evaluate the feasibility of commercial transfer if possible. Guy’s, St Thomas, and King’s College Hospital (part of King’s Health Partners) will provide valuable clinical samples for final validation stage. Other collaborators will advise on 3D-printing, pancreatic cancer and biomarkers. These interdisplinary contributions are essential and well-related to the proposal research, fostering high-quality cooperation from biology, chemistry, engineering, nanotechnology and clinical areas the other way round.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences chemical sciences analytical chemistry
- engineering and technology nanotechnology
- medical and health sciences clinical medicine oncology
- natural sciences biological sciences molecular biology
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
WC2R 2LS London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.