Objective Childhood obesity is currently at epidemic rates, with serious risks for cardiovascular disease in adulthood and premature death. Obesity is known to accelerate the initiation of endothelial dysfunction and alter the hemodynamics in young arteries. In alignment with urgent EU and worldwide policies on understanding childhood adiposity, we propose to develop a novel and safe computational tool to study numerically, for the first time, the obesity-altered hemodynamics in children and adolescents. The project aims to transfer the non-invasive computational fluid dynamic technology to the paediatric practice and enable personalised prediction of cardiovascular disease and effective decision-making. Within a multi-scale modeling framework, the proposed study seeks to utilise high-fidelity state-of-the-art numerical methods and develop new ones, for the implementation and coupling of the 3D flow in anatomically realistic arterial geometries with macroscopic and microscopic information, ensuring high stability and accuracy of results. In conjunction with clinicians, the study will perform patient-specific numerical simulations, correlated with medical data, and help towards individualized treatment planning, with a significant impact on the quality of life of the young patient. This multidisciplinary perspective is fundamental in elucidating early vascular changes induced by obesity and predict cardiovascular disease risks, while protecting the young population. Fields of science medical and health sciencesclinical medicinecardiologycardiovascular diseasesnatural sciencesphysical sciencesclassical mechanicsfluid mechanicsfluid dynamicscomputational fluid dynamicsnatural sciencescomputer and information sciencescomputational sciencemultiphysicsmedical and health scienceshealth sciencesnutritionobesitynatural sciencesmathematicsapplied mathematicsnumerical analysis Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2016 - Individual Fellowships Call for proposal H2020-MSCA-IF-2016 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator UNIVERSITY OF STRATHCLYDE Net EU contribution € 183 454,80 Address Richmond Street 16 G1 1XQ Glasgow United Kingdom See on map Region Scotland West Central Scotland Glasgow City Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Total cost € 183 454,80