Objective
Surface-induced thrombosis and infection are two main complications which cause failure of medical devices. Device-related thrombosis is associated with activation of blood clotting and platelets adhesion and activation. Infection of the implanted devices occurred as a result of bacteria adhesion to the biomaterial surface. A genuinely biocompatible polymer for blood-contacting devices should have both antithrombotic and antibacterial functionalities as both types of complication lead to an increase in morbidity, extended hospital stay and mortality.
In order to prevent device-induced thrombosis and infection novel dual function polymer materials - thromboresistant and antimicrobial, will be produced. A novel and original approach that involves construction of multifunctional coatings, which combine formulation of the NO-generating surface with the ability to prevent bacterial adhesion, capacity to inhibit platelet adhesion and the use of surface bound argatroban drug to inhibit any surface-produced thrombin, will be applied. The polymer matrices chosen for the design of dual function materials are the most commonly used synthetic polymers polyurethane (PU) and polyvinylchloride (PVC) and the biopolymer collagen. This aim will be achieved by: i) chemical attachment of the organoselenium or copper nanoparticle catalysts to the polymer surface in order to continuously generate NO by decomposition of endogenous S-nitrosothiols; ii) immobilisation of the direct thrombin inhibitor argatroban to inhibit any thrombin in the surrounding environment. Catecholamines, polydopamine and poly(norepinephrine) will be used as the surface modification reagents, as they form very stable thin films strongly attached to the polymer surface. Owing to the chemical bonding of the ligand to the polymer surface it is expected that these materials will have long storage life and exploitation period and therefore retain their ability to generate NO from the inexhaustible endogenous NO donors.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences microbiology bacteriology
- natural sciences chemical sciences polymer sciences polyurethane
- engineering and technology materials engineering coating and films
- natural sciences chemical sciences catalysis
- engineering and technology industrial biotechnology biomaterials
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-CAR - CAR – Career Restart panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
BN2 4AT Brighton
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.