Objective
Stroke is the second leading cause of mortality worldwide. Most stroke events are triggered by an atherosclerotic plaque rupture in a carotid artery. Current clinical decisions for the carotid plaque removal surgery are made without assessing the plaque rupture risk as no reliable means exists today. Biomechanics can help to develop such risk assessment tools; yet, the fundamental knowledge on biomechanical descriptors of plaque rupture is missing.
This project aims to provide biomechanical characteristics of atherosclerotic plaque rupture. This will be done by combining experimental work, high-end plaque imaging and computational modeling. First, non-existing biomechanical plaque rupture data will be collected from a novel experimental approach of physiological, ex-vivo inflation/rupture tests with atherosclerotic human carotid arteries. The pre-rupture and rupture strain distributions in plaques during the tests will be assessed in 3D via a cutting-edge high frequency ultrasound technique. With a novel inverse finite element (FE) technique, heterogeneous material properties of the plaques will be identified. This unique material information will be used in plaque-specific FE models to compute 3D pre-rupture and rupture stress distributions in the plaques. The assessed plaque strain and stress fingerprints will be evaluated for their predictive value of plaque rupture.
The essential knowledge on biomechanical characteristics of plaque rupture will aid making more accurate surgical treatment decisions to prevent stroke-related mortality and morbidity. Besides the high-impact research, this fellowship will also result in enhancement of the applicant’s skill set through the valuable training on ultrasound imaging, histology and pathomorphology examination. Furthermore, the fellowship will allow him to return to the EU research environment, and bring back his expertise in tissue experimentation and modeling, and advanced FE analysis.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences medical biotechnology
- medical and health sciences clinical medicine cardiology cardiovascular diseases arteriosclerosis
- medical and health sciences clinical medicine surgery surgical procedures
- medical and health sciences basic medicine neurology stroke
- natural sciences biological sciences biophysics
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-RI - RI – Reintegration panel
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
3015 GD Rotterdam
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.