Objective
Breast cancer is one of the most diagnosed cancers and the leading cause of cancer death in women worldwide. Breast cancer cells need activated receptor tyrosine kinases (RTKs) to invade, proliferate, and metastasize. Increased activity and overexpression of RTKs is associated with poor prognosis for breast cancer patients. Therefore, multiple RTKs have emerged as attractive therapeutic targets. However, resistance to therapies is a persistent problem for the development of therapeutics targeting RTKs. New and innovative approaches to effectively target these receptors are required. Recently S-palmitoylation has been identified as an important post-translational modification that regulates signal transduction, protein trafficking and degradation of specific RTKs in breast cancer. The substrate scope, role, extent of dysregulation and the enzymes responsible for the S-palmitoylation of specific substrates in breast cancer is largely unknown. In this context, the aim of the proposed project is to implement novel chemical biological tools and methods, to gain insight in the extent, regulation and role of S-palmitoylation of RTKs in breast cancer. This insight will facilitate the identification of new approaches to therapeutically target RTKs in breast cancer.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering crystals
- natural sciences biological sciences biochemistry biomolecules proteins proteomics
- natural sciences biological sciences biochemistry biomolecules lipids
- medical and health sciences clinical medicine oncology breast cancer
- natural sciences biological sciences biochemistry biomolecules proteins enzymes
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
SW7 2AZ London
United Kingdom
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.