Objective Photoacoustic imaging, an emerging multi-wave imaging modality that couples light excitation to acoustic detection via the photoacoustic effect (sound generation via light absorption), relies on detecting ultrasound waves that are very weakly scattered in biological tissue. It provides acoustic-resolution images of optical absorption non-invasively at large depth (up to several cm). However, ultrasound attenuation increases with frequency, limiting the depth-to-resolution ratio to about 100. An alternative to overcome the dispersion of light in tissue due to scattering is using thin, micron-sized diameter optical fibers to both deliver and collect light from the sample. A novel idea and preliminary proof-of-concept experiment has just been demonstrated by Prof. Bossy’s team where a dual waveguide allows also to remotely detect high frequency ultrasound with the same device as that used for guiding light. This device can act both as a multi-mode optical waveguide for the illumination and fluorescence collection using the outer cladding, and as a waveguide to guide the ultrasound out of the tissue using the core, avoiding the absorption by the tissue and increasing the penetration depth.The overall objective of DARWIN is to study and develop a new type of dual-modality endoscope for optical-resolution photoacoustic and fluorescence microscopy based on a capillary waveguide. To do so, a high speed phase modulator will measure the transmission matrix and calibrate the endoscope providing a way to display any optical patterns at the distal tip. The fellow will explore different configurations where a thin hydrophone, based on a single mode fiber or a needle, is inserted inside the core improving the acoustic signal detection. Furthermore, bending compensation will be investigated. DARWIN will result in a prototype thin endoscope for dual microscopy imaging, an important tool for in-vivo experiments, such as the neuron imaging. Fields of science engineering and technologymaterials engineeringfibersnatural sciencesphysical sciencesopticsmicroscopynatural sciencesphysical sciencesopticsfibre opticsnatural sciencesphysical sciencesacousticsultrasound Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2016 - Individual Fellowships Call for proposal H2020-MSCA-IF-2016 See other projects for this call Funding Scheme MSCA-IF-EF-ST - Standard EF Coordinator UNIVERSITE GRENOBLE ALPES Net EU contribution € 173 076,00 Address 621 avenue centrale 38058 Grenoble France See on map Region Auvergne-Rhône-Alpes Rhône-Alpes Isère Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
