Objective
Photoacoustic imaging, an emerging multi-wave imaging modality that couples light excitation to acoustic detection via the photoacoustic effect (sound generation via light absorption), relies on detecting ultrasound waves that are very weakly scattered in biological tissue. It provides acoustic-resolution images of optical absorption non-invasively at large depth (up to several cm). However, ultrasound attenuation increases with frequency, limiting the depth-to-resolution ratio to about 100. An alternative to overcome the dispersion of light in tissue due to scattering is using thin, micron-sized diameter optical fibers to both deliver and collect light from the sample. A novel idea and preliminary proof-of-concept experiment has just been demonstrated by Prof. Bossy’s team where a dual waveguide allows also to remotely detect high frequency ultrasound with the same device as that used for guiding light. This device can act both as a multi-mode optical waveguide for the illumination and fluorescence collection using the outer cladding, and as a waveguide to guide the ultrasound out of the tissue using the core, avoiding the absorption by the tissue and increasing the penetration depth.
The overall objective of DARWIN is to study and develop a new type of dual-modality endoscope for optical-resolution photoacoustic and fluorescence microscopy based on a capillary waveguide. To do so, a high speed phase modulator will measure the transmission matrix and calibrate the endoscope providing a way to display any optical patterns at the distal tip. The fellow will explore different configurations where a thin hydrophone, based on a single mode fiber or a needle, is inserted inside the core improving the acoustic signal detection. Furthermore, bending compensation will be investigated. DARWIN will result in a prototype thin endoscope for dual microscopy imaging, an important tool for in-vivo experiments, such as the neuron imaging.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- engineering and technology materials engineering fibers
- natural sciences physical sciences optics microscopy
- natural sciences physical sciences optics fibre optics
- natural sciences physical sciences acoustics ultrasound
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
38058 GRENOBLE
France
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.