Generally, the beneficiaries of our work include academia; industry, including biotechnology; policymakers; medical research charities; scientific journals; research councils; international funding agencies; the students within the Group; and the general public. Due to the collaborative nature of the programme, direct outcomes are expected in both countries UK and Poland. Clinical scientists in a number of fields from animal to human health, including clinical and cancer epigenetics, obstetrics and gynaecology, child health and reproductive health and infertility, will also benefit. Indeed, the programme made possible various collaborations within the research circle in Cambridge, and in Europe. I am now working closely with Dr Miguel Constancia, from the Institute of Metabolic Sciences, University of Cambridge, on methods for studying adipocyte biology. Additionally, I have also established a collaborative effort with the research group of Dr Joris Vrien, Leuven University, Belgium, to further study the impact of obesity in uterine function and infertility in women.
The data generated are being now submitted to journals listed in the Journal Citation Reports. The programme also provided an opportunity for students from the laboratory in Poland (Institute of Animal Reproduction and Food Research), to come to Babraham and access state of the art methods on sequencing and imaging methods.
Other beneficiaries were the Babraham Impact team (Knowledge Exchange and Commercialisation), with whom I have discussed potential opportunities to commercialise the data, and contacts were made with the Centre for Science and Policy (CSAP), University of Cambridge.
Results dessimination:
Proceedings in International Conferences
Talks by Galvão A
1) Galvão A, et al. Effects of maternal obesity on oocyte methylome are reflected on blastocyst epigenome, “Mechanisms and Evolution of Intergenerational Change”, 24-26th September 2019. ppS45.
2) Galvão A, et al. How Maternal Obesity Affects the Oocyte Epigenome and Preimplantation Embryos, “3rd Danube Conference on Epigenetics”, 9th – 12th October 2018, Budapest Hungary. Pp 38.
3) Galvão A, et al. Maternal Obesity Modulates the Oocyte Methylome and Transcriptome , “Society for Study of Reproduction and Fertility”, 10th – 13th July 2018, New Orleans, USA. Flash talk. Pp143.
Posters
1) Walewska E, Witek K, Kelsey G, Galvão A, Obesity Alters Leptin Signalling in Mouse Uterus: Putative Link to Epigenetic Regulation during Decidualisation. Centre for Trophoblast Research Annual Conference, 8th-9th July 2019 Saint John’s College Cambridge, UK
2) Galvão A, et al. Maternal obesity affects the epigenome of oocytes and preimplantation embryos. “Advances at the interface between metabolism and epigenetics”, 16th-17th January 2019, Robinson College, Cambridge, UK.
3) Wołodko K, Walewska E, Adamowski M, Galvao A, Leptin Signalling Characterisation in the Ovary of Diet-Induced Obese and Pharmacologically Hyperleptinemic Mouse, “Society for Study of Reproduction and Fertility”, 10th – 13th July 2018, New Orleans, USA. Flash talk. Pp: 52.
4) Adamowski M , Wołodko K, Galvao A, Ovarian-specific Regulation of Inflammasome in Obese Mice; “Society for Study of Reproduction and Fertility”, 10th – 13th July 2018, New Orleans, USA. Pp: 136.
5) Galvão A,et a . Maternal obesity affects the oocyte epigenome in mice. “Epigenomics of Common Diseases”, 14th-17th November 2017, Welcome Genome Campus, Hinxton, Cambridge, UK. Pp:P15.
Public engagement
16th-17th March 2019 “Cambridge Science Festival”, Race against the aging clock, Cambridge, UK
2nd-8th July 2018 “Royal Society Summer Science Exhibition”, Race against the aging clock, London, UK
