Objective
Vertebrates, which include our own species, are the most diverse and successful group of Deuterostomes. Success of this group has been explained by the evolution of elaborated head skeleton adapted to capturing and processing large prey. Most of this skeleton derives from neural crest cells migrating into the pharynx during and after the formation of pharyngeal pouches. To better understand how development of these structures evolved, the research project will study representatives of three basal fish lineages that occupy key positions in jawed-vertebrate phylogeny. It will employ methods of genomics, gene expression, and gene manipulation including CRISPR/Cas9 gene editing system to test a mechanistic model of pouch formation and its relationships to pre-oral endoderm development. The proposal builds upon the Fellow’s research of jawed and jawless vertebrates and bridges a gap in our knowledge of the pharyngeal evolution between the jawed and jawless vertebrates and at the same time between vertebrates and their chordate and deuterostome ancestors. Two-way knowledge transfer is a crucial feature of this project: the Fellow will take advantage of the proficiency of the Supervisor and the Department in embryology, morphology, manipulation, and husbandry of the rare basal fishes and in the genomics and transcriptomics, while at the same time he will transfer his expertise in genetic regulation of development and CRISPR/Cas9 gene editing in non-model organisms to the Supervisor and Host Institution.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences biological morphology comparative morphology
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences genetics mutation
- natural sciences biological sciences zoology ichthyology
- natural sciences mathematics pure mathematics mathematical analysis functional analysis
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
116 36 Praha 1
Czechia
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.