Objective
This project aims at reconstructing the ancestry and oral disease of Palaeolithic, Neolithic and Bronze Age anatomically modern humans from Central-Southern Italy, using genome-wide profiling and mass spectrometry-based proteomic analysis of skeletal remains and mineralised dental plaque (archaeological dental calculus). In Europe, the transition from hunter-gatherer to agricultural communities (Neolithisation) and the Bronze Age migration into Central Europe from the Asian steppe were the most important demographic events since the initial peopling by anatomically modern humans. However, until now, no Palaeolithic and only a few of Neolithic and Bronze age individuals from South Europe have been characterised for genomic analysis. As a consequence, the genetic base of outstanding peopling and migratory processes in prehistoric Europe, such as: (a) the East-West population structure among European hunter-gatherers, and (b) the Neolithic Southern European horizon known as the Cardial culture, still need to be fully understood. Similarly, metagenomic analysis of Palaeolithic and Neolithic dental calculus has been limited to preliminary screening of a limited number of samples, with no associated metaproteomic analysis. What taxonomic groups and metabolic functions were lost or gained with Neolithisation? How this affected oral heath? The genomic characterisation of Palaeolithic, Neolithic and Bronze Age humans from Southern Europe will be integrated with a metagenomic and metaproteomic analysis of dental calculus to produce the richest possible personal “-omics” profiling so far achievable for ancient humans. The two main research objectives are: 1. Integrate Palaeolithic, Neolithic and Bronze Age human genomic data from Central-Southern Italy within the genomic landscape available for all ancient and present-day West Eurasians, and 2. Reconstruct the oral microbiome, and its metabolic interactions with the host, before and after Neolithisation.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
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Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions
MAIN PROGRAMME
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H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
MSCA-IF-EF-ST - Standard EF
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) H2020-MSCA-IF-2016
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
1165 KOBENHAVN
Denmark
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.