Periodic Reporting for period 1 - HeartATAC (Epigenetic regulation of cardiac regeneration after injury.)
Reporting period: 2017-07-01 to 2019-06-30
The goal of this proposal is to better understand the mechanisms by which the heart switches from a proliferative, pro-regenerative state during development to a quiescent, non-regenerative state in adulthood, to ultimately apply this knowledge to reverse clinical phenotypes after myocardial infarction.
We have identified molecular pathways that are involved in the regulation of heart muscle cell proliferation, and we describe how Arid1a interacts with these pathways. Based on these observations we conclude that Arid1a is involved in suppression of heart muscle cell response to injury, and that removal of Arid1a is not sufficient to unlock the tightly regulated cell cycle in the heart.
The results of this study were presented at multiple international scientific conferences in Europe and the US. The results of this project are currently being prepared for publication in international peer-reviewed scientific journals, complying with the standards for open access. Datasets generated during this study will be made available to the scientific community through public databases upon publication of accepted manuscripts.