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Multi-layered biomimetics of lytic polysaccharide monooxygenases

Objective

The high stability of components like cellulose limit the efficiency and cost effectiveness of biofuel or chemical production from lignocellulosic biomass. Thus, the ability of the recently discovered class of metalloenzymes, lytic polysaccharide monooxygenases (LPMO), to enhance the efficiency of recalcitrant polysaccharide degradation makes understanding these enzymes invaluable for carbon friendly sustainable chemical and energy development as prioritized under the Horizon2020 program.
The current project seeks to develop multi-layered biomimetics of the LPMO active site that can offer unprecedented replication first and second coordination sphere groups, in order to be able to rationally study the collection of interactions that contribute to enzyme activity.
The research involves the design and chemical synthesis of aromatic oligoamide scaffolds that incorporate a specific copper binding site. Through synthetic modification of the scaffold to alter the second coordination sphere, and combined spectroscopic and electrochemical methods, changes in the properties and reactivity of the metal site will be studied with a goal of developing a structure- function relationship that can assist in guiding enzyme modification, as well as, new synthetic catalyst development.
The applicant has a strong background in synthetic chemistry and mechanistic studies that will be crucial to the success of the project. Through joining the host lab in Belgium that specializes in coordination and supramolecular chemistry, she will greatly increase her own knowledge base, while transferring her knowledge of synthetic organic chemistry to the host. Additionally, during proposed secondments to work with a collaborator in Germany for the electrochemical studies, the applicant will further expand the gain and transfer of knowledge and strengthen international collaboration between the groups involved.

Field of science

  • /engineering and technology/environmental engineering/energy and fuels/biofuels
  • /natural sciences/chemical sciences/organic chemistry
  • /natural sciences/biological sciences/biochemistry/biomolecules/carbohydrates
  • /agricultural sciences/agricultural biotechnology/biomass
  • /natural sciences/biological sciences/biochemistry/biomolecules/proteins/enzymes

Call for proposal

H2020-MSCA-IF-2016
See other projects for this call

Funding Scheme

MSCA-IF-EF-ST - Standard EF

Coordinator

UNIVERSITE CATHOLIQUE DE LOUVAIN
Address
Place De L Universite 1
1348 Louvain La Neuve
Belgium
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 160 800