Objective The idea of transmitting paternal environmental impact across generations has been indicated and described in studies across species, but the mechanism is still unclear. The overall aim of the project is to test whether H3K27me3, a type of epigenetic modification on histone 3 [1], is involved in transmitting environmental impact across generation to influence the behavior of offspring. With a behavioral neuroscience background, the experienced research (ER) will apply his expertise in high throughput behavioral assay and combine techniques he will learn from the host lab, including epigenetic profiling, NGS, targeted epigenome editing and computational analysis to address specifically whether paternal drug experience influence offspring behavior via modifying H3K27me3 on dopamine-related genes that are involved in various behaviors [2]. Besides advancing our understanding of the importance and mechanism of paternal inheritance and the role of epigenetics in general, this project will also further extend zebrafish as a model in studying cross-generational transmission of environmental experience by combining multidisciplinary techniques. The trainings ER will be beneficial and essential for his future goal to study epigenetic mechanisms underlying physiology and pathology of brain. Fields of science natural sciencesbiological sciencesneurobiologynatural sciencesearth and related environmental sciencesenvironmental sciencespollutionnatural scienceschemical sciencesorganic chemistryalcoholsnatural sciencesbiological sciencesgeneticsgenomesnatural sciencesbiological sciencesgeneticsepigenetics Keywords epigenomics zebra fish trans-generational epigenetic inheritance Programme(s) H2020-EU.1.3. - EXCELLENT SCIENCE - Marie Skłodowska-Curie Actions Main Programme H2020-EU.1.3.2. - Nurturing excellence by means of cross-border and cross-sector mobility Topic(s) MSCA-IF-2016 - Individual Fellowships Call for proposal H2020-MSCA-IF-2016 See other projects for this call Funding Scheme MSCA-IF - Marie Skłodowska-Curie Individual Fellowships (IF) Coordinator THE UNIVERSITY OF BIRMINGHAM Net EU contribution € 195 454,80 Address Edgbaston B15 2TT Birmingham United Kingdom See on map Region West Midlands (England) West Midlands Birmingham Activity type Higher or Secondary Education Establishments Links Contact the organisation Opens in new window Website Opens in new window Participation in EU R&I programmes Opens in new window HORIZON collaboration network Opens in new window Other funding € 0,00
