A small molecule AMP activated protein kinase (AMPK) activator, denoted O304, as a novel innovative drug for the treatment of type 2 diabetes

Objective

This project aims to close the gap to the market for a small molecule AMP activated protein kinase (AMPK) activator,
denoted O304, as a novel first-in-class drug for the treatment of type 2 diabetes (T2D) and associated cardiovascular
complications, including heart failure and peripheral arterial disease.

The number of adults around the world with diabetes quadrupled from 108 million in 1980 to 422 million in 2014. About 90%
of these people have type 2 diabetes — a major cause of kidney failure, blindness, nerve damage, amputations, heart attack
and stroke. It is estimated that only approx. 10 % of T2 diabetics reach the goal of living a complication free life.
Today, patients diagnosed with T2D are recommended a change in lifestyle and the drug Metformin is the first line of
treatment. When Metformin becomes insufficient, a number of add-on treatments are used, including insulin. None of the
existing drugs, however, reduces insulin resistance - a primary cause of obesity-induced T2D.

Betagenon has developed and pre-validated the first candidate AMPK activator drug in T2 diabetics, a key regulator of
energy balance, both on a single cell level and the whole organism level. Phase I clinical data show that O304 reduces
fasting plasma glucose, the hallmark of T2D, in patients with T2D on stable metformin treatment, and increases the rate of
hyperaemic blood in calf muscle in middle aged obese individuals. The project is strategically focused on performing a
Phase IIa proof-of-concept validation of O304. This will enable Betagenon to commercialize the product through outlicensing
to a Phase IIb and Phase III validation partner.

Diabetes is an epidemic that threatens the economies of all EU member states. The project addresses this challenge by
delivering a novel drug treatment regimen to clinicians and their patients. O304 will fill the knowledge gap on the EU level, as
to date no company has been able to pre-validate an efficient small molecule AMPK activator.

Fields of science

Programme(s)

Topic(s)

SMEInst-03-2016-2017 - Dedicated support to biotechnology SMEs closing the gap from lab to market

Call for proposal

H2020-SMEInst-2016-2017

See other projects for this call

Sub call

H2020-SMEINST-2-2016-2017

Funding Scheme

SME-2 - SME instrument phase 2

Coordinator

BETAGENON AB

Net EU contribution

€ 1 823 237,50

Address

Tvistevagen 48c
907 36 Umea
Sweden

Region

Norra Sverige Övre Norrland Västerbottens län

Activity type

Private for-profit entities (excluding Higher or Secondary Education Establishments)

Links

Contact the organisation

Participation in EU R&I programmes

HORIZON collaboration network

Other funding

€ 781 387,50