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The EUropean TRAnsplantation and INnovation (EU-TRAIN) consortium for improving diagnosis and risk stratification in kidney transplant patients

Objective

Rejection is the major cause of allograft failure with dramatic consequences in terms of mortality, morbidity and increased cost for the society. The field of transplantation lacks a robust assessment of risk stratification. Thus, it impairs the development of relevant clinical trials to address graft and patient outcomes. We formed the EU-TRAIN project by gathering reference kidney transplant centres in a fully operating European network including 12 partners. Our ambitious but realistic goals are: to provide clinicians with innovative and accessible tools for early prediction of individual risk of allograft rejection and transplant loss; to personalise clinical management and treatment and; to improve allograft outcomes. This project will engineer a risk stratification system applied to kidney transplant patients by analysing the integration of several layers of data (clinical, histological, immunological data as well as gene expression and novel biomarkers) - the TRAnsplant Comprehensive Evaluator of Risk (EU-TRACER). EU-TRACER will be generated and validated in 2 dedicated studies including a randomised control trial. Translation to patients will be achieved by delivering: 1) A multiplex non-invasive biomarker system for the stratification and immune monitoring of low and high risk kidney recipients; 2) A prognostic system for individual risk stratification for allograft rejection and failure that will assist decision making via an interactive web interface. The EU-TRACER, developed with our 3 industrial partners, will define a new standard of care in transplantation. The EU-TRACER will have the potential for a large implementation and diffusion in other centres in Europe and will be suitable for industrial collaboration.

Call for proposal

H2020-SC1-2017-Two-Stage-RTD
See other projects for this call

Funding Scheme

RIA - Research and Innovation action

Coordinator

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
Address
Rue De Tolbiac 101
75654 Paris
France
Activity type
Research Organisations
EU contribution
€ 1 025 447

Participants (11)

INSTITUT CATALA DE LA SALUT
Spain
EU contribution
€ 750 597
Address
Gran Via De Les Corts Catalanes 587
08007 Barcelona
Activity type
Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
CHARITE - UNIVERSITAETSMEDIZIN BERLIN
Germany
EU contribution
€ 898 236
Address
Chariteplatz 1
10117 Berlin
Activity type
Higher or Secondary Education Establishments
ASSISTANCE PUBLIQUE HOPITAUX DE PARIS
France
EU contribution
€ 1 154 520
Address
3 Avenue Victoria
75000 Paris
Activity type
Research Organisations
CELLTREND GESELLSCHAFT MIT BESCHRANKTER HAFTUNG
Germany
EU contribution
€ 208 313
Address
Im Biotechnologiepark Tgz Ii
14943 Luckenwalde
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
INSERM TRANSFERT SA
France
EU contribution
€ 391 875
Address
Rue Watt 7
75013 Paris
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
OXFORD IMMUNOTEC LIMITED
United Kingdom
EU contribution
€ 303 841
Address
94C Innovation Drive, Milton Park Oxfordshire
OX14 4RZ Abingdon
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CENTRE HOSPITALIER UNIVERSITAIRE DE NANTES
France
EU contribution
€ 1 207 741
Address
Allee De L'ile Gloriette 5
44093 Nantes
Activity type
Higher or Secondary Education Establishments
CERNER FRANCE
France
EU contribution
€ 96 563
Address
5 Place De La Pyramide, Tour Ariane
92800 Puteaux
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSITE DE GENEVE
Switzerland
EU contribution
€ 444 413
Address
Rue Du General Dufour 24
1211 Geneve
Activity type
Higher or Secondary Education Establishments
EUROPEAN SOCIETY FOR ORGAN TRANSPLANTATION
Netherlands
EU contribution
€ 120 000
Address
Westerdoksdijk 423
1013 BX Amsterdam
Activity type
Other
ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK
France
EU contribution
€ 40 000
Address
5 Rue Watt
75013 Paris
Activity type
Research Organisations