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Hide and Seek with Cancer Drugs

Objective

Cancer is one of the most prominent causes for morbidity and mortality in industrialized countries. The key challenge in drug-based anti-cancer therapy is to efficiently kill the cancer cells while minimizing side-effects on healthy parts of the body. The DeShield project will establish the proof of concept for a novel approach to upgrade existing anti-cancer drugs in a way that the anti-cancer effect will be increased while side-effects will simultaneously minimized. DeShield technology will be used to shield approved anti-cancer drugs while circulating in the body in order to minimize side effects. Once the shielded drug accumulated at the cancer site, an external stimulus will be applied to trigger de-shielding. The drug will then locally and specifically be taken up by the cancer cells to exert its therapeutic effect. We have successfully demonstrated the functionality of the DeShield technology using the clinically approved anti-cancer drug Doxil and human cancer cell lines: when the shield is intact, the drug is not taken up by the cells, only upon inducible un-shielding the drug enters and kills the cells. In the DeShield project we aim at establishing the Proof-of-Concept that this approach is functional in cancer animal models, that it increases the therapeutic effect while minimizing side-effects. To this aim we have assembled a team with high expertise in complementary areas covering the technology itself, the conductance of preclinical animal studies up to clinical trials as well as business expertise. The technical advance obtained in this project together with a comprehensive market research and the development of a business strategy will shape a highly attractive commercial proposition for the successful valorization of our ERC-funded research.

Fields of science (EuroSciVoc)

CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.

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Programme(s)

Multi-annual funding programmes that define the EU’s priorities for research and innovation.

Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-POC - Proof of Concept Grant

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2016-PoC

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Host institution

ALBERT-LUDWIGS-UNIVERSITAET FREIBURG
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 149 981,00
Address
FAHNENBERGPLATZ
79098 Freiburg
Germany

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Region
Baden-Württemberg Freiburg Freiburg im Breisgau, Stadtkreis
Activity type
Higher or Secondary Education Establishments
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 149 981,00

Beneficiaries (1)

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