Objective
Therapeutic antibodies represent an important class of newly introduced drugs and have been particularly successful in cancer therapy and the treatment of inflammatory diseases. The clearance rates of therapeutic antibodies are known to differ per individual and correlate with survival rates. Being able to define a personalized dose per patient based on continuous monitoring of therapeutic antibody levels would therefore be beneficial both for the individual patient and for the hospital’s budget. Our group recently developed a new platform of bioluminescent sensor proteins for antibody detection that allow antibody detection directly in blood plasma using the camera of a smart phone as the sole piece of equipment.
The goal of this ERC Proof-of-Concept is to establish LUMABS as a unique, low cost, and easily accessible point-of-care technology for monitoring therapeutic antibodies.
To enable clinical and commercial translation a product portfolio will be established that includes the development and validation of a prototype point-of-care assay for the therapeutic antibody Cetuximab. To establish LUMABS as a broadly applicable platform technology, we will use recently developed epitope screening technology to develop specific LUMABS sensors targeting Infliximab and biosimilar antibodies that are used to treat inflammatory conditions such as Crohns’ disease and rheumatoid arthritis. Based on an in-depth market analysis and the feedback we receive from external stakeholders on the performance of our technology, a realistic strategy will be developed for further translation and commercialization. During the project we will continuously assess opportunities for new patent applications. Our IP strategy will be guided by the outcome of our market examination and analysis of the most interesting business opportunities.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine rheumatology
- medical and health sciences health sciences inflammatory diseases
- medical and health sciences clinical medicine gastroenterology inflammatory bowel disease
- medical and health sciences clinical medicine oncology
- engineering and technology electrical engineering, electronic engineering, information engineering information engineering telecommunications mobile phones
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-POC - Proof of Concept Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2016-PoC
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.