Design of Nanomaterials for Targeted Therapies Guided by Super Resolution Imaging

Project Information

NANOSTORM

Grant agreement ID: 757397

DOI

10.3030/757397

Project closed

EC signature date 25 January 2018

Start date 1 February 2018

End date 31 July 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 497 588,00

EU contribution

€ 1 497 588,00

Coordinated by

TECHNISCHE UNIVERSITEIT EINDHOVEN
Netherlands

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (29)

Aptamers with Tunable Affinity Enable Single‐Molecule Tracking and Localization of Membrane Receptors on Living Cancer Cells

Author(s): Pietro Delcanale, David Porciani, Silvia Pujals, Alexander Jurkevich, Andrian Chetrusca, Kwaku D. Tawiah, Donald H. Burke, Lorenzo Albertazzi
Published in: Angewandte Chemie International Edition, Issue 59/42, 2020, Page(s) 18546-18555, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202004764

Single-molecule imaging of glycan-lectin interactions on cells with Glyco-PAINT

Author(s): Roger Riera, Tim P. Hogervorst, Ward Doelman, Yan Ni, Silvia Pujals, Evangelia Bolli, Jeroen D. C. Codée, Sander I. van Kasteren & Lorenzo Albertazzi
Published in: Nature Chemical Biology, 2021, ISSN 1552-4450
Publisher: Nature Publishing Group
DOI: 10.1038/s41589-021-00896-2

Precision and Accuracy of Receptor Quantification on Synthetic and Biological Surfaces Using DNA-PAINT

Author(s): Roger Riera; Emmanouil Archontakis; Glenn Cremers; Tom de Greef; Peter Zijlstra; Lorenzo Albertazzi
Published in: Acs Sensors, 2023, ISSN 2379-3694
Publisher: American Chemical Society
DOI: 10.1021/acssensors.2c01736

Formulation of tunable size PLGA-PEG nanoparticles for drug delivery using microfluidic technology.

Author(s): Adrianna Glinkowska Mares; Gaia Pacassoni; Josep Martí; Silvia Pujals; Lorenzo Albertazzi
Published in: PLoS ONE, 16(6):e0251821. Public Library of Science, Issue 1, 2021, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0251821

PAINT‐ing Fluorenylmethoxycarbonyl (Fmoc)‐Diphenylalanine Hydrogels

Author(s): Edgar Fuentes, Kamila Boháčová, Ana M. Fuentes‐Caparrós, Ralf Schweins, Emily R. Draper, Dave J. Adams, Silvia Pujals, Lorenzo Albertazzi
Published in: Chemistry – A European Journal, Issue 26/44, 2020, Page(s) 9869-9873, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202001560

Beyond the Stability-Responsiveness Trade-off

Author(s): Edgar Fuentes; Yeray Gabaldón; Mario Collado; Shikha Dhiman; José Augusto Berrocal; Silvia Pujals; Lorenzo Albertazzi
Published in: VOLUME=144;ISSUE=46;ISSN=0002-7863;TITLE=Journal of the American Chemical Society, Issue 1, 2022, ISSN 1520-5126
Publisher: American chemical society
DOI: 10.1021/jacs.2c08528

A quantitative view on multivalent nanomedicine targeting

Author(s): Laura Woythe, Nicholas B. Tito, Lorenzo Albertazzi
Published in: ADDR, 2021, ISSN 0169-409X
Publisher: Elsevier BV
DOI: 10.1016/j.addr.2020.11.010

Unveiling Polymerization Mechanism in pH-regulated Supramolecular Fibers in Aqueous Media.

Author(s): Nicolás M. Casellas; Nicolás M. Casellas; Lorenzo Albertazzi; Silvia Pujals; Tomás Torres; Tomás Torres; Miguel García-Iglesias; Miguel García-Iglesias; Miguel García-Iglesias
Published in: reponame:Repositorio Institucional del Instituto Madrileño de Estudios Avanzados en Nanociencia, Issue 1, 2021, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202101660

From Cells to Virus-Like Particles

Author(s): Maria Arista-Romero; Pietro Delcanale; Silvia Pujals; Lorenzo Albertazzi
Published in: ACS Photonics, Issue 1, 2022, ISSN 2330-4022
Publisher: American Chemical Society
DOI: 10.1021/acsphotonics.1c01154

Mapping the relationship between total and functional antibodies conjugated to nanoparticles with spectrally-resolved direct stochastic optical reconstruction microscopy (SR-dSTORM)

Author(s): Emmanouil Archontakis; Laura Woythe; Bas van Hoof; Lorenzo Albertazzi
Published in: Nanoscale Advances, 2022, ISSN 2516-0230
Publisher: Royal Society of chemistry
DOI: 10.1039/d2na00435f

Mapping Antibody Domain Exposure on Nanoparticle Surfaces Using DNA-PAINT

Author(s): Marrit M. E. Tholen; Bas J. H. M. Rosier; Robin T. Vermathen; Céline A. N. Sewnath; Cornelis Storm; Laura Woythe; Cristina Izquierdo-Lozano; Roger Riera; Marjolein van Egmond; Maarten Merkx; Lorenzo Albertazzi
Published in: ACS Nano, 2023, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.3c02195

Can Super-Resolution Microscopy Become a Standard Characterization Technique for Material Chemistry?

Author(s): Shikha Dhiman; Teodora Andrian; Beatriz Santiago; Marrit Tholen; Yuyang Wang; Lorenzo Albertazzi
Published in: instname:Universidad de Barcelona, Issue 1, 2021, ISSN 1478-6524
Publisher: Royal Society of Chemcistry
DOI: 10.1039/d1sc05506b

Super-resolution microscopy reveals significant impact of M2e-specific monoclonal antibodies on influenza A virus filament formation at the host cell surface

Author(s): Annasaheb Kolpe, Maria Arista-Romero, Bert Schepens, Silvia Pujals, Xavier Saelens, Lorenzo Albertazzi
Published in: Scientific Reports, Issue 9/1, 2019, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-019-41023-5

Super-resolution microscopy as a powerful tool to study complex synthetic materials

Author(s): Silvia Pujals, Natalia Feiner-Gracia, Pietro Delcanale, Ilja Voets, Lorenzo Albertazzi
Published in: Nature Reviews Chemistry, Issue 3/2, 2019, Page(s) 68-84, ISSN 2397-3358
Publisher: Nature Publishing Group
DOI: 10.1038/s41570-018-0070-2

Super-resolution Microscopy for Nanomedicine Research

Author(s): Silvia Pujals, Lorenzo Albertazzi
Published in: ACS Nano, 2019, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.9b05289

Super-resolution Imaging of Structure, Molecular Composition, and Stability of Single Oligonucleotide Polyplexes

Author(s): Natalia Feiner-Gracia, R. Alis Olea, Robert Fitzner, Najoua El Boujnouni, Alexander H. van Asbeck, Roland Brock, Lorenzo Albertazzi
Published in: Nano Letters, Issue 19/5, 2019, Page(s) 2784-2792, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.8b04407

A stochastic view on surface inhomogeneity of nanoparticles

Author(s): R. A. J. Post, D. van der Zwaag, G. Bet, S. P. W. Wijnands, L. Albertazzi, E. W. Meijer, R. W. van der Hofstad
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-09595-y

Artificial Antigen-Presenting Cell Topology Dictates T Cell Activation

Author(s): Annelies Wauters, Jari Scheerstra, Laura Woythe, Wu, Hanglong, Albertazzi Lorenzo, Figdor Carl G, Tel, Jurjen, Abdelmohsen Loai, van Hest Jan
Published in: ACS nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.2c06211

Real-Time Ratiometric Imaging of Micelles Assembly State in a Microfluidic Cancer-on-a-Chip

Author(s): Natalia Feiner-Gracia, Adrianna Glinkowska Mares, Marina Buzhor, Romen Rodriguez-Trujillo, Josep Samitier Marti, Roey J. Amir, Silvia Pujals, Lorenzo Albertazzi
Published in: ACS Applied Bio Materials, Issue 4/1, 2021, Page(s) 669-681, ISSN 2576-6422
Publisher: American Chemical Society
DOI: 10.1021/acsabm.0c01209

Towards a Quantitative Single Particle Characterization by Super Resolution Microscopy: From Virus Structures to Antivirals Design

Author(s): Maria Arista-Romero; Silvia Pujals; Silvia Pujals; Lorenzo Albertazzi; Lorenzo Albertazzi
Published in: Frontiers in Bioengineering and Biotechnology, 2021, ISSN 2296-4185
Publisher: Frontiers media
DOI: 10.3389/fbioe.2021.647874

Identification of fluorescently-barcoded nanoparticles using machine learning

Author(s): Ana Ortiz-Perez; Cristina Izquierdo-Lozano; Rens Meijers; Francesca Grisoni; Lorenzo Albertazzi
Published in: Nanoscale Advances, Issue 1, 2023, ISSN 2516-0230
Publisher: Royal society of chemistry
DOI: 10.1039/d2na00648k

Valency and affinity control of aptamer-conjugated nanoparticles for selective cancer cell targeting

Author(s): Laura Woythe; David Porciani; Tessa Harzing; Stijn van Veen; Donald H. Burke; Lorenzo Albertazzi
Published in: VOLUME=355;STARTPAGE=228;ENDPAGE=237;ISSN=0168-3659;TITLE=Journal of Controlled Release, Issue 1, 2023, ISSN 0168-3659
Publisher: Elsevier BV
DOI: 10.1016/j.jconrel.2023.01.008

Correlating Ligand Functionality and Cell Receptor Density

Author(s): Laura Woythe; Pranav Madhikar; Natalia Feiner-Gracia; Cornelis Storm; Lorenzo Albertazzi
Published in: ACS Nano, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c08277

Enabling spectrally resolved single-molecule localization microscopy at high emitter densities

Author(s): Koen J.A. Martens; Martijn Gobes; Emmanouil Archontakis; Roger R. Brillas; Niels Zijlstra; Lorenzo Albertazzi; Johannes Hohlbein
Published in: Nano letters, Issue 1, 2022, ISSN 1556-276X
Publisher: American chemical society
DOI: 10.1101/2022.06.29.498127

Multivalent effect of peptide functionalized polymeric nanoparticles towards selective prostate cancer targeting

Author(s): Madhura Murar; Silvia Pujals; Lorenzo Albertazzi
Published in: Nanoscale Advances, 5(5), 1378 - 1385. Royal Society of Chemistry, Issue 1, 2023, ISSN 2516-0230
Publisher: Royal Society of Chemistry
DOI: 10.1039/d2na00601d

Tracking the DNA complexation state of pBAE polyplexes in cells with super resolution microscopy

Author(s): Roger Riera, Natalia Feiner-Gracia, Cristina Fornaguera, Anna Cascante, Salvador Borrós, Lorenzo Albertazzi
Published in: Nanoscale, Issue 11/38, 2019, Page(s) 17869-17877, ISSN 2040-3364
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9nr02858g

Multicolor Super-Resolution Microscopy of Protein Corona on Single Nanoparticles

Author(s): Yuyang Wang; Paul E. D. Soto Rodriguez; Laura Woythe; Samuel Sánchez; Josep Samitier; Peter Zijlstra; Lorenzo Albertazzi
Published in: urn:issn:1944-8244, Issue 1, 2022, ISSN 1944-8244
Publisher: American Chemical Society
DOI: 10.1021/acsami.2c06975

Single-Particle Functionality Imaging of Antibody-Conjugated Nanoparticles in Complex Media

Author(s): Laura Woythe; Marrit M. E. Tholen; Bas J. H. M. Rosier; Lorenzo Albertazzi
Published in: ACS Appl. Bio Mater., 2023, ISSN 2576-6422
Publisher: American Chemical society
DOI: 10.1021/acsabm.2c00830

Enzyme Purification Improves the Enzyme Loading, Self-Propulsion, and Endurance Performance of Micromotors

Author(s): Morgane Valles; Sílvia Pujals; Lorenzo Albertazzi; Samuel Sánchez
Published in: instname:Universidad de Barcelona, Issue 1, 2022, ISSN 1936-0851
Publisher: American Chemical Society
DOI: 10.1021/acsnano.1c10520