Impact and interaction of prophage elements in bacterial host strains of biotechnological relevance

Project Information

PRO_PHAGE

Grant agreement ID: 757563

DOI 10.3030/757563

Project closed

EC signature date 5 September 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 482 672,00

EU contribution € 1 482 672,00

Coordinated by

FORSCHUNGSZENTRUM JULICH GMBH
Germany

Publications

Peer reviewed articles (18)

Aminoglycoside Antibiotics Inhibit Phage Infection by Blocking an Early Step of the Infection Cycle

Author(s): Larissa Kever; Aël Hardy; Tom Luthe; Max Hünnefeld; Cornelia Gätgens; Lars Milke; Johanna Wiechert; Johannes Wittmann; Cristina Moraru; Jan Marienhagen; Julia Frunzke
Published in: mBio, Issue 3, 2022, ISSN 2150-7511
Publisher: American Society of Microbiology (ASM)
DOI: 10.1128/mbio.00783-22

Antiphage small molecules produced by bacteria – beyond protein-mediated defenses

Author(s): Aël Hardy; Larissa Kever; Julia Frunzke
Published in: Trends in Microbiology, 2022, ISSN 1878-4380
Publisher: Cell Press
DOI: 10.1016/j.tim.2022.08.001

Genome Sequence and Characterization of Five Bacteriophages Infecting Streptomyces coelicolor and Streptomyces venezuelae: Alderaan, Coruscant, Dagobah, Endor1 and Endor2

Author(s): Aël Hardy, Vikas Sharma, Larissa Kever, Julia Frunzke
Published in: Viruses, Issue 12/10, 2020, Page(s) 1065, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12101065

Genome Sequence of the Bacteriophage CL31 and Interaction with the Host Strain Corynebacterium glutamicum ATCC 13032

Author(s): Max Hünnefeld; Ulrike Viets; Vikas Sharma; Astrid Wirtz; Aël Hardy; Julia Frunzke
Published in: Viruses, 2021, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030495

Identification of Gip as a novel phage-encoded gyrase inhibitor protein of Corynebacterium glutamicum.

Author(s): Larissa Kever; Max Hünnefeld; Jannis Brehm; Ralf Heermann; Julia Frunzke
Published in: Molecular Microbiology, Issue 2, 2021, ISSN 1365-2958
Publisher: Wiley-Blackwell
DOI: 10.1111/mmi.14813

Phylogenetic Distribution of WhiB- and Lsr2-Type Regulators in Actinobacteriophage Genomes

Author(s): Vikas Sharma; Aël Hardy; Tom Luthe; Julia Frunzke
Published in: Microbiology Spectrum, 2021, ISSN 2165-0497
Publisher: American Society of Microbiology (ASM)
DOI: 10.1128/spectrum.00727-21

Bacterial multicellular behavior in antiviral defense

Author(s): Luthe, Tom; Kever, Larissa; Thormann, Kai; Frunzke, Julia
Published in: Current Opinion in Microbiology, 2023, ISSN 1369-5274
Publisher: Elsevier BV
DOI: 10.1016/j.mib.2023.102314

Streptomyces development is involved in the efficient containment of viral infections

Author(s): Luthe, Tom; Kever, Larissa; Hänsch, Sebastian; Hardy, Aël; Tschowri, Natalie; Weidtkamp-Peters, Stefanie; Frunzke, Julia
Published in: microLife, 2023, ISSN 2633-6693
Publisher: Oxford Academic
DOI: 10.1093/femsml/uqad002

Isolation of Novel Xanthomonas Phages Infecting the Plant Pathogens X. translucens and X. campestris

Author(s): Sebastian H. Erdrich; Vikas Sharma; Ulrich Schurr; Borjana Arsova; Julia Frunzke
Published in: Viruses; Volume 14; Issue 7; Pages: 1449, Issue 2, 2022, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14071449

The diversity of heme sensor systems – heme-responsive transcriptional regulation mediated by transient heme protein interactions

Author(s): Aileen Krüger; Marc Keppel; Vikas Sharma; Julia Frunzke
Published in: FEMS microbiology reviews 45(3), fuac002 (2022). doi:10.1093/femsre/fuac002, Issue 9, 2022, ISSN 1574-6976
Publisher: Oxford academid
DOI: 10.1093/femsre/fuac002

The MarR-Type Regulator MalR Is Involved in Stress-Responsive Cell Envelope Remodeling in Corynebacterium glutamicum

Author(s): Max Hünnefeld, Marcus Persicke, Jörn Kalinowski, Julia Frunzke
Published in: Frontiers in Microbiology, Issue 10, 2019, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2019.01039

Cytometry meets next-generation sequencing – RNA-Seq of sorted subpopulations reveals regional replication and iron-triggered prophage induction in Corynebacterium glutamicum

Author(s): Raphael Freiherr von Boeselager, Eugen Pfeifer, Julia Frunzke
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-32997-9

Generation of a Prophage-Free Variant of the Fast-Growing Bacterium Vibrio natriegens

Author(s): Eugen Pfeifer, Slawomir Michniewski, Cornelia Gätgens, Eugenia Münch, Felix Müller, Tino Polen, Andrew Millard, Bastian Blombach, Julia Frunzke
Published in: Applied and Environmental Microbiology, Issue 85/17, 2019, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.00853-19

Impact of Xenogeneic Silencing on Phage–Host Interactions

Author(s): Eugen Pfeifer, Max Hünnefeld, Ovidiu Popa, Julia Frunzke
Published in: Journal of Molecular Biology, 2019, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.02.011

HrrSA orchestrates a systemic response to heme and determines prioritization of terminal cytochrome oxidase expression

Author(s): Marc Keppel, Max Hünnefeld, Andrei Filipchyk, Ulrike Viets, Cedric-Farhad Davoudi, Aileen Krüger, Christina Mack, Eugen Pfeifer, Tino Polen, Meike Baumgart, Michael Bott, Julia Frunzke
Published in: Nucleic Acids Research, Issue 48/12, 2020, Page(s) 6547-6562, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa415

Inducible Expression Systems Based on Xenogeneic Silencing and Counter-Silencing and Design of a Metabolic Toggle Switch

Author(s): Johanna Wiechert, Cornelia Gätgens, Astrid Wirtz, Julia Frunzke
Published in: ACS Synthetic Biology, 2020, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.0c00111

Deciphering the Rules Underlying Xenogeneic Silencing and Counter-Silencing of Lsr2-like Proteins Using CgpS of Corynebacterium glutamicum as a Model

Author(s): Johanna Wiechert, Andrei Filipchyk, Max Hünnefeld, Cornelia Gätgens, Jannis Brehm, Ralf Heermann, Julia Frunzke
Published in: mBio, Issue 11/1, 2020, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.02273-19

Systematic analysis of prophage elements in actinobacterial genomes reveals a remarkable phylogenetic diversity

Author(s): Sharma, Vikas; Hünnefeld, Max; Luthe, Tom; Frunzke, Julia
Published in: Scientific reports 13(1), 4410 (2023). doi:10.1038/s41598-023-30829-z, Issue 3, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-30829-z