Impact and interaction of prophage elements in bacterial host strains of biotechnological relevance

Project Information

PRO_PHAGE

Grant agreement ID: 757563

DOI

10.3030/757563

Project closed

EC signature date 5 September 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 482 672,00

EU contribution

€ 1 482 672,00

Coordinated by

FORSCHUNGSZENTRUM JULICH GMBH
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (18)

Aminoglycoside Antibiotics Inhibit Phage Infection by Blocking an Early Step of the Infection Cycle

Author(s): Larissa Kever; Aël Hardy; Tom Luthe; Max Hünnefeld; Cornelia Gätgens; Lars Milke; Johanna Wiechert; Johannes Wittmann; Cristina Moraru; Jan Marienhagen; Julia Frunzke
Published in: mBio, Issue 3, 2022, ISSN 2150-7511
Publisher: American Society of Microbiology (ASM)
DOI: 10.1128/mbio.00783-22

Antiphage small molecules produced by bacteria – beyond protein-mediated defenses

Author(s): Aël Hardy; Larissa Kever; Julia Frunzke
Published in: Trends in Microbiology, 2022, ISSN 1878-4380
Publisher: Cell Press
DOI: 10.1016/j.tim.2022.08.001

Genome Sequence and Characterization of Five Bacteriophages Infecting Streptomyces coelicolor and Streptomyces venezuelae: Alderaan, Coruscant, Dagobah, Endor1 and Endor2

Author(s): Aël Hardy, Vikas Sharma, Larissa Kever, Julia Frunzke
Published in: Viruses, Issue 12/10, 2020, Page(s) 1065, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v12101065

Genome Sequence of the Bacteriophage CL31 and Interaction with the Host Strain Corynebacterium glutamicum ATCC 13032

Author(s): Max Hünnefeld; Ulrike Viets; Vikas Sharma; Astrid Wirtz; Aël Hardy; Julia Frunzke
Published in: Viruses, 2021, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v13030495

Identification of Gip as a novel phage-encoded gyrase inhibitor protein of Corynebacterium glutamicum.

Author(s): Larissa Kever; Max Hünnefeld; Jannis Brehm; Ralf Heermann; Julia Frunzke
Published in: Molecular Microbiology, Issue 2, 2021, ISSN 1365-2958
Publisher: Wiley-Blackwell
DOI: 10.1111/mmi.14813

Phylogenetic Distribution of WhiB- and Lsr2-Type Regulators in Actinobacteriophage Genomes

Author(s): Vikas Sharma; Aël Hardy; Tom Luthe; Julia Frunzke
Published in: Microbiology Spectrum, 2021, ISSN 2165-0497
Publisher: American Society of Microbiology (ASM)
DOI: 10.1128/spectrum.00727-21

Bacterial multicellular behavior in antiviral defense

Author(s): Luthe, Tom; Kever, Larissa; Thormann, Kai; Frunzke, Julia
Published in: Current Opinion in Microbiology, 2023, ISSN 1369-5274
Publisher: Elsevier BV
DOI: 10.1016/j.mib.2023.102314

Streptomyces development is involved in the efficient containment of viral infections

Author(s): Luthe, Tom; Kever, Larissa; Hänsch, Sebastian; Hardy, Aël; Tschowri, Natalie; Weidtkamp-Peters, Stefanie; Frunzke, Julia
Published in: microLife, 2023, ISSN 2633-6693
Publisher: Oxford Academic
DOI: 10.1093/femsml/uqad002

Isolation of Novel Xanthomonas Phages Infecting the Plant Pathogens X. translucens and X. campestris

Author(s): Sebastian H. Erdrich; Vikas Sharma; Ulrich Schurr; Borjana Arsova; Julia Frunzke
Published in: Viruses; Volume 14; Issue 7; Pages: 1449, Issue 2, 2022, ISSN 1999-4915
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/v14071449

The diversity of heme sensor systems – heme-responsive transcriptional regulation mediated by transient heme protein interactions

Author(s): Aileen Krüger; Marc Keppel; Vikas Sharma; Julia Frunzke
Published in: FEMS microbiology reviews 45(3), fuac002 (2022). doi:10.1093/femsre/fuac002, Issue 9, 2022, ISSN 1574-6976
Publisher: Oxford academid
DOI: 10.1093/femsre/fuac002

The MarR-Type Regulator MalR Is Involved in Stress-Responsive Cell Envelope Remodeling in Corynebacterium glutamicum

Author(s): Max Hünnefeld, Marcus Persicke, Jörn Kalinowski, Julia Frunzke
Published in: Frontiers in Microbiology, Issue 10, 2019, ISSN 1664-302X
Publisher: Frontiers Media
DOI: 10.3389/fmicb.2019.01039

Cytometry meets next-generation sequencing – RNA-Seq of sorted subpopulations reveals regional replication and iron-triggered prophage induction in Corynebacterium glutamicum

Author(s): Raphael Freiherr von Boeselager, Eugen Pfeifer, Julia Frunzke
Published in: Scientific Reports, Issue 8/1, 2018, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-018-32997-9

Generation of a Prophage-Free Variant of the Fast-Growing Bacterium Vibrio natriegens

Author(s): Eugen Pfeifer, Slawomir Michniewski, Cornelia Gätgens, Eugenia Münch, Felix Müller, Tino Polen, Andrew Millard, Bastian Blombach, Julia Frunzke
Published in: Applied and Environmental Microbiology, Issue 85/17, 2019, ISSN 0099-2240
Publisher: American Society for Microbiology
DOI: 10.1128/aem.00853-19

Impact of Xenogeneic Silencing on Phage–Host Interactions

Author(s): Eugen Pfeifer, Max Hünnefeld, Ovidiu Popa, Julia Frunzke
Published in: Journal of Molecular Biology, 2019, ISSN 0022-2836
Publisher: Academic Press
DOI: 10.1016/j.jmb.2019.02.011

HrrSA orchestrates a systemic response to heme and determines prioritization of terminal cytochrome oxidase expression

Author(s): Marc Keppel, Max Hünnefeld, Andrei Filipchyk, Ulrike Viets, Cedric-Farhad Davoudi, Aileen Krüger, Christina Mack, Eugen Pfeifer, Tino Polen, Meike Baumgart, Michael Bott, Julia Frunzke
Published in: Nucleic Acids Research, Issue 48/12, 2020, Page(s) 6547-6562, ISSN 0305-1048
Publisher: Oxford University Press
DOI: 10.1093/nar/gkaa415

Inducible Expression Systems Based on Xenogeneic Silencing and Counter-Silencing and Design of a Metabolic Toggle Switch

Author(s): Johanna Wiechert, Cornelia Gätgens, Astrid Wirtz, Julia Frunzke
Published in: ACS Synthetic Biology, 2020, ISSN 2161-5063
Publisher: American Chemical Society
DOI: 10.1021/acssynbio.0c00111

Deciphering the Rules Underlying Xenogeneic Silencing and Counter-Silencing of Lsr2-like Proteins Using CgpS of Corynebacterium glutamicum as a Model

Author(s): Johanna Wiechert, Andrei Filipchyk, Max Hünnefeld, Cornelia Gätgens, Jannis Brehm, Ralf Heermann, Julia Frunzke
Published in: mBio, Issue 11/1, 2020, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.02273-19

Systematic analysis of prophage elements in actinobacterial genomes reveals a remarkable phylogenetic diversity

Author(s): Sharma, Vikas; Hünnefeld, Max; Luthe, Tom; Frunzke, Julia
Published in: Scientific reports 13(1), 4410 (2023). doi:10.1038/s41598-023-30829-z, Issue 3, 2023, ISSN 2045-2322
Publisher: Nature Publishing Group
DOI: 10.1038/s41598-023-30829-z