Evolutionary biology of human and great ape brain development in cerebral organoids

Project Information

CerebralHominoids

Grant agreement ID: 757710

DOI 10.3030/757710

Project closed

EC signature date 28 June 2018

Start date 1 July 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 444 911,00

EU contribution € 1 444 911,00

Coordinated by

UNITED KINGDOM RESEARCH AND INNOVATION
United Kingdom

Publications

Peer reviewed articles (8)

Cerebral organoids at the air–liquid interface generate diverse nerve tracts with functional output

Author(s): Stefano L. Giandomenico, Susanna B. Mierau, George M. Gibbons, Lea M. D. Wenger, Laura Masullo, Timothy Sit, Magdalena Sutcliffe, Jerome Boulanger, Marco Tripodi, Emmanuel Derivery, Ole Paulsen, András Lakatos, Madeline A. Lancaster
Published in: Nature Neuroscience, Issue 22/4, 2019, Page(s) 669-679, ISSN 1097-6256
Publisher: Nature Publishing Group
DOI: 10.1038/s41593-019-0350-2

Androgens increase excitatory neurogenic potential in human brain organoids

Author(s): Kelava I, Chiaradia I, Pellegrini L, Kalinka AT, Lancaster MA.
Published in: Nature, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-021-04330-4

SARS-CoV-2 Infects the Brain Choroid Plexus and Disrupts the Blood-CSF Barrier in Human Brain Organoids

Author(s): Pellegrini L, Albecka A, Mallery DL, Kellner MJ, Paul D, Carter AP, James LC, Lancaster MA.
Published in: Cell Stem Cell, 2020, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.10.001

An early cell shape transition drives evolutionary expansion of the human forebrain

Author(s): Silvia Benito-Kwiecinski, Stefano L. Giandomenico, Magdalena Sutcliffe, Erlend S. Riis, Paula Freire-Pritchett, Iva Kelava, Stephanie Wunderlich, Ulrich Martin, Gregory A. Wray, Kate McDole, Madeline A. Lancaster
Published in: Cell, Issue 184/8, 2021, Page(s) 2084-2102.e19, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2021.02.050

Disease modelling in human organoids

Author(s): Madeline A. Lancaster, Meritxell Huch
Published in: Disease Models & Mechanisms, Issue 12/7, 2019, Page(s) dmm039347, ISSN 1754-8403
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dmm.039347

Generation and long-term culture of advanced cerebral organoids for studying later stages of neural development

Author(s): Stefano L. Giandomenico, Magdalena Sutcliffe, Madeline A. Lancaster
Published in: Nature Protocols, Issue 16/2, 2021, Page(s) 579-602, ISSN 1754-2189
Publisher: Nature Publishing Group
DOI: 10.1038/s41596-020-00433-w

Human CNS barrier-forming organoids with cerebrospinal fluid production

Author(s): Laura Pellegrini, Claudia Bonfio, Jessica Chadwick, Farida Begum, Mark Skehel, Madeline A. Lancaster
Published in: Science, Issue 369/6500, 2020, Page(s) eaaz5626, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.aaz5626

Electron cryo-tomography reveals the subcellular architecture of growing axons in human brain organoids.

Author(s): Patrick C. Hoffmann; Stefano L. Giandomenico; Iva Ganeva; Michael R. Wozny; Magdalena Sutcliffe; Madeline A. Lancaster; Wanda Kukulski; Wanda Kukulski
Published in: eLife, 2021, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.17863/cam.77428

Non-peer reviewed articles (1)

Breaking the barrier: In vitro models to study choroid plexus development.

Author(s): Laura Pellegrini; Madeline A. Lancaster
Published in: Current Opinion in Cell Biology, 2021, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2021.05.005

Intellectual Property Rights

Patent (1)

CHOROID PLEXUS ORGANOIDS AND METHODS FOR PRODUCTION THEREOF

Application/Publication number: 20 20051631
Date: 2020-01-23