Objective
Ultrasound (US) is the modality of choice for imaging and functional measurements of the cardiovascular system due to its high spatial and temporal resolution. In recent years, the use of US has been on the rise owing to huge advancements in acquisition speed and resolution. Nevertheless, because of physical constraints, several issues —limited field-of-view, refraction, resolution and, contrast anisotropy— cannot be resolved using a single probe.
This proposal will aim at tackling these issues introducing Multi-perspective Ultrasound Strain Imaging & Elastography (MUSE). MUSE will push the frontiers of 3-D US imaging by introducing a novel, multi-perspective 3-D US system. The revolutionary system will consist of two synchronously controlled 3-D matrix arrays and advanced signal and image processing to improve geometric and functional measurements (strain, elasticity). Validation will be performed for two applications: cardiac strain imaging in patients with aortic valve stenosis (AoS) and elastography of abdominal aortic aneurysms (AAA).
Fusion of dual-probe data will be challenged and achieved by new algorithms, preserving important features and improving both contrast and field-of-view. Advanced 3-D processing of the raw US data will be developed for motion and strain imaging. A novel compounding technique, fusion strain imaging, will combine multi-perspective strain data to improve accuracy and precision. A comprehensive framework for system verification and validation will be built, comprising US simulations, ex vivo experiments, and in vivo pilot studies on healthy volunteers. The proposed technique will be validated in AoS and AAA patients.
Ultimately, MUSE will introduce a non-invasive, ground-breaking US platform for functional screening and follow-up, and a breakthrough in early diagnosis, clinical decision making, and risk assessment of cardiovascular disease. Moreover, MUSE has the potential to replace invasive or costly imaging modalities with US.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- medical and health sciences clinical medicine angiology vascular diseases
- medical and health sciences clinical medicine cardiology cardiovascular diseases
- natural sciences physical sciences acoustics ultrasound
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2017-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
5612 AE Eindhoven
Netherlands
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.