Periodic Reporting for period 2 - BONDS (Bilayered ON-Demand Scaffolds: On-Demand Delivery from induced Pluripotent Stem Cell Derived Scaffolds for Diabetic Foot Ulcers)
Reporting period: 2019-04-01 to 2020-09-30
The on-demand delivery system was successfully adapted for releasing genes at specific timepoints. However, to fully enhance their activity, further optimisation is required. In parallel, we developed an alternative, more stable, DNA-based nanoparticle, which we could successfully release and demonstrated its bioactivity. This nanoparticle could be loaded with chemotherapeutic drugs and was capable of limiting cancer cell growth in vitro.
Ultimately, we believe the two systems need to be combined together to form an effective wound healing device. Thus, we have developed two versions of the device. In the first, the on-demand delivery system is integrated throughout the scaffold. We demonstrated its ability to release nanoparticles on demand within the scaffold. In the second version, we incorporated the drug delivery device in discrete locations within the scaffold. This enables the operator to release different drugs at different timepoints by targeting the discrete areas."