Deciphering virus-host interactions using correlated confocal-atomic force microscopy

Project Information

NanoVirus

Grant agreement ID: 758224

DOI

10.3030/758224

Project closed

EC signature date 25 September 2017

Start date 1 January 2018

End date 31 December 2022

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 998 125,00

EU contribution

€ 1 998 125,00

Coordinated by

UNIVERSITE CATHOLIQUE DE LOUVAIN
Belgium

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (16)

Reovirus directly engages integrin to recruit clathrin for entry into host cells

Author(s): M. Koehler, S.J.L. Petitjean, J. Yang, P. Aravamudhan, X. Somoulay, C. Lo Giudice, M.A. Poncin, A.C. Dumitru, T.S. Dermody, D. Alsteens
Published in: Nature Communications, Issue 20411723, 2021, Page(s) 2149, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22380-0

Stepwise Enzymatic-Dependent Mechanism of Ebola Virus Binding to Cell Surface Receptors Monitored by AFM

Author(s): Qingrong Zhang; Jinsung Yang; Sueli Tillieux; Zhengyuan Guo; Rita dos Santos Natividade; Melanie Koehler; Simon Petitjean; Zongqiang Cui; David Alsteens
Published in: Nano Letters, Vol. 22, no.4, p. 1641-1648 (2022), Issue 15306984, 2022, Page(s) 1641-1648, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c04677

Rotavirus Binding to Cell Surface Receptors Directly Recruiting α2 Integrin

Author(s): J. Yang, J. Park, M. Koehler, J. Simpson, Da. Luque, J. M. Rodríguez, D. Alsteens
Published in: Advanced Nanobiomed Research, Issue 1, 2021, Page(s) 2100077, ISSN 2699-9307
Publisher: Wiley-VCH GmbH
DOI: 10.1002/anbr.202100077

Molecular insights into receptor binding energetics and neutralization of SARS-CoV-2 variants

Author(s): M. Koehler, A. Ray, R.A. Moreira, B. Juniku, A.B. Poma, D. Alsteens
Published in: Nature Communications, Issue 20411723, 2021, Page(s) 6977, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27325-1

Altered Glycan Expression on Breast Cancer Cells Facilitates Infection by T3 Seroptype Oncolytic Reovirus

Author(s): D. Mohammed, M. Koehler, A.C. Dumitru, P. Aravamudhan, D.M. Sutherland, T.S. Dermody & David Alsteens
Published in: Nano Letters, Issue 15306984, 2021, Page(s) 9720-9728, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.1c03608

Multivalent binding of herpesvirus to living cells is tightly regulated during infection

Author(s): Martin Delguste, Caroline Zeippen, Bénédicte Machiels, Jan Mast, Laurent Gillet, David Alsteens
Published in: Science Advances, Issue 4/8, 2018, Page(s) eaat1273, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aat1273

Initial Step of Virus Entry: Virion Binding to Cell-Surface Glycans

Author(s): Melanie Koehler, Martin Delguste, Christian Sieben, Laurent Gillet, David Alsteens
Published in: Annual Review of Virology, Issue 7/1, 2020, ISSN 2327-056X
Publisher: Annual Reviews
DOI: 10.1146/annurev-virology-122019-070025

Atomic force microscopy-based mechanobiology

Author(s): Michael Krieg, Gotthold Fläschner, David Alsteens, Benjamin M. Gaub, Wouter H. Roos, Gijs J. L. Wuite, Hermann E. Gaub, Christoph Gerber, Yves F. Dufrêne, Daniel J. Müller
Published in: Nature Reviews Physics, Issue 1/1, 2019, Page(s) 41-57, ISSN 2522-5820
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s42254-018-0001-7

Seeing and sensing single G protein-coupled receptors by atomic force microscopy

Author(s): K Tanuj Sapra, Patrizia M Spoerri, Andreas Engel, David Alsteens, Daniel J Müller
Published in: Current Opinion in Cell Biology, Issue 57, 2019, Page(s) 25-32, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2018.10.006

Glycan-mediated enhancement of reovirus receptor binding

Author(s): Melanie Koehler, Pavithra Aravamudhan, Camila Guzman-Cardozo, Andra C. Dumitru, Jinsung Yang, Serena Gargiulo, Patrice Soumillion, Terence S. Dermody, David Alsteens
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-019-12411-2

Endophilin-A3 and Galectin-8 control the clathrin-independent endocytosis of CD166

Author(s): Henri-François Renard, François Tyckaert, Cristina Lo Giudice, Thibault Hirsch, Cesar Augusto Valades-Cruz, Camille Lemaigre, Massiullah Shafaq-Zadah, Christian Wunder, Ruddy Wattiez, Ludger Johannes, Pierre van der Bruggen, David Alsteens, Pierre Morsomme
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-15303-y

Control of Ligand-Binding Specificity Using Photocleavable Linkers in AFM Force Spectroscopy

Author(s): Melanie Koehler, Cristina Lo Giudice, Philipp Vogl, Andreas Ebner, Peter Hinterdorfer, Hermann J. Gruber, David Alsteens
Published in: Nano Letters, Issue 20/5, 2020, Page(s) 4038-4042, ISSN 1530-6984
Publisher: American Chemical Society
DOI: 10.1021/acs.nanolett.0c01426

Molecular interaction and inhibition of SARS-CoV-2 binding to the ACE2 receptor

Author(s): J. Yang, S. J.L. Petitjean, M. Koehler, Q. Zhang, A C. Dumitru, W. Chen, S. Derclaye, S.P. Vincent, P. Soumillion, D. Alsteens
Published in: Nature Communications, Issue 20411723, 2020, Page(s) 4541, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18319-6

Atomic force microscopy applied to interrogate nanoscale cellular chemistry and supramolecular bond dynamics for biomedical applications

Author(s): Joshua D. Simpson; Ankita Ray; Melanie Koehler; Danahe Mohammed; David Alsteens
Published in: Chemical Communications, Vol. 58, no.33, p. 5072-5087 (2022), Issue 13597345, 2022, Page(s) 5072-5087, ISSN 1359-7345
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc07200e

Multivalent 9-O-Acetylated-sialic acid glycoclusters as potent inhibitors for SARS-CoV-2 infection

Author(s): S. J. L. Petitjean, W. Chen, M. Koehler, R. Jimmidi, J. Yang, D. Mohammed, B. Juniku, M. Stanifer, S. Boulant, S. Vincent, D. Alsteens
Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-30313-8

Reovirus σ1 Conformational Flexibility Modulates the Efficiency of Host Cell Attachment

Author(s): J.R. Diller, S.R. Halloran, M. Koehler, R. Dos Santos Natividade, D. Alsteens, T. Stehle, T.S. Dermody, K.M. Ogden
Published in: Journal of Virology, Issue 23, 2020, Page(s) e01163-20, ISSN 0022-538X
Publisher: American Society for Microbiology
DOI: 10.1128/jvi.01163-20