Competition for Space in Development and Diseases

Project Information

CoSpaDD

Grant agreement ID: 758457

DOI

10.3030/758457

Project closed

EC signature date 4 October 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 489 147,00

EU contribution

€ 1 489 147,00

Coordinated by

INSTITUT PASTEUR
France

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (10)

Toward a predictive understanding of epithelial cell death

Author(s): Tom Cumming, Romain Levayer
Published in: Seminars in Cell & Developmental Biology, 2023, ISSN 1096-3634
Publisher: Elsevier
DOI: 10.1016/j.semcdb.2023.06.008

LocalZProjector and DeProj: a toolbox for local 2D projection and accurate morphometrics of large 3D microscopy images.

Author(s): Sébastien Herbert; Léo Valon; Laure Mancini; Laure Mancini; Nicolas Dray; Paolo Caldarelli; Jerome Gros; Elric Esposito; Spencer L. Shorte; Laure Bally-Cuif; Romain Levayer; Nathalie Aulner; Jean-Yves Tinevez
Published in: BMC Biology, Issue 19, 2022, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-021-01037-w

Dying under pressure: cellular characterisation and in vivo functions of cell death induced by compaction

Author(s): Léo Valon, Romain Levayer
Published in: Biology of the Cell, Issue 111/3, 2019, Page(s) 51-66, ISSN 0248-4900
Publisher: Portland Press, Ltd.
DOI: 10.1111/boc.201800075

Competition for Space Induces Cell Elimination through Compaction-Driven ERK Downregulation

Author(s): Eduardo Moreno, Léo Valon, Florence Levillayer, Romain Levayer
Published in: Current Biology, Issue 29/1, 2019, Page(s) 23-34.e8, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2018.11.007

Solid stress, competition for space and cancer: The opposing roles of mechanical cell competition in tumour initiation and growth

Author(s): Romain Levayer
Published in: Seminars in Cancer Biology, 2019, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2019.05.004

Multiple Influences of Mechanical Forces on Cell Competition

Author(s): Alexis Matamoro-Vidal, Romain Levayer
Published in: Current Biology, Issue 29/15, 2019, Page(s) R762-R774, ISSN 0960-9822
Publisher: Cell Press
DOI: 10.1016/j.cub.2019.06.030

DeXtrusion: automatic recognition of epithelial cell extrusion through machine learning in vivo

Author(s): Alexis Villars , Gaëlle Letort , Léo Valon, Romain Levayer
Published in: Development, Issue Volume 150, Issue 13, 2023, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.201747

Collective effects in epithelial cell death and cell extrusion.

Author(s): Alexis Villars; Romain Levayer
Published in: Current Opinion in Genetics and Development, Issue Voume 72, 2022, Page(s) 8-14, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2021.09.004

Microtubule disassembly by caspases is the rate-limiting step of cell extrusion

Author(s): Alexis Villars; Alexis Matamoro-Vidal; Florence Levillayer; Romain Levayer
Published in: Nature Communications, Issue 13, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1101/2021.10.15.464503

Robustness of epithelial sealing is an emerging property of local ERK feedback driven by cell elimination.

Author(s): Léo Valon; Anđela Davidović; Florence Levillayer; Alexis Villars; Alexis Villars; Mathilde Chouly; Fabiana Cerqueira-Campos; Romain Levayer
Published in: Developmental Cell, Issue Volume 56, issue 12, 2021, Page(s) 1700-1711, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.05.006

Book chapters (1)

Chapter Five - Cell polarity and extrusion: How to polarize extrusion and extrude misspolarized cells?

Author(s): Ralitza Staneva, Romain Levayer
Published in: Current Topics in Developmental Biology, Issue Volume 154, 2023, Page(s) 131-167, ISBN 978-0-12-820158-9
Publisher: Elsevier
DOI: 10.1016/bs.ctdb.2023.02.010

Non-peer reviewed articles (1)

Patterned apoptosis has an instructive role for local growth and tissue shape regulation in a fast-growing epithelium

Author(s): Alexis Matamoro-Vidal; Tom Cumming; Anđela Davidović; Romain Levayer
Published in: BioRxiv, Issue 1, 2022, ISSN 2692-8205
Publisher: CSH
DOI: 10.1101/2022.03.11.484029

Other (1)

Robustness of epithelial sealing is an emerging property of local ERK feedbacks driven by cell elimination

Author(s): Léo Valon, Anđela Davidović, Florence Levillayer, Mathilde Chouly, Fabiana Cerqueira-Campos, Romain Levayer
Published in: Bioarchive, 2020
Publisher: Bioarchive
DOI: 10.1101/2020.03.17.994921