Structural differences in mRNA translation machineries between eukaryotic pathogens and their mammalian hosts

Project Information

transtryp

Grant agreement ID: 759120

DOI 10.3030/759120

Project closed

EC signature date 27 October 2017

Start date 1 January 2018

End date 30 June 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 787 400,00

EU contribution € 1 787 400,00

Coordinated by

INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
France

Publications

Peer reviewed articles (8)

The Halastavi árva Virus Intergenic Region IRES Promotes Translation by the Simplest Possible Initiation Mechanism

Author(s): Irina S. Abaeva, Quentin Vicens, Anthony Bochler, Heddy Soufari, Angelita Simonetti, Tatyana V. Pestova, Yaser Hashem, Christopher U.T. Hellen
Published in: Cell Reports, Issue 33/10, 2020, Page(s) 108476, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108476

Structure of the mature kinetoplastids mitoribosome and insights into its large subunit biogenesis

Author(s): Heddy Soufari, Florent Waltz, Camila Parrot, Stéphanie Durrieu-Gaillard, Anthony Bochler, Lauriane Kuhn, Marie Sissler, Yaser Hashem
Published in: Proceedings of the National Academy of Sciences, Issue 117/47, 2020, Page(s) 29851-29861, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2011301117

How to build a ribosome from RNA fragments in Chlamydomonas mitochondria

Author(s): Florent Waltz, Thalia Salinas-Giegé, Robert Englmeier, Herrade Meichel, Heddy Soufari, Lauriane Kuhn, Stefan Pfeffer, Friedrich Förster, Benjamin D Engel, Philippe Giegé, Laurence Drouard, Yaser Hashem
Published in: Nature Communications, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27200-z

Structural Differences in Translation Initiation between Pathogenic Trypanosomatids and Their Mammalian Hosts

Author(s): Anthony Bochler, Jailson Brito Querido, Terezie Prilepskaja, Heddy Soufari, Angelita Simonetti, Mayara Lucia Del Cistia, Lauriane Kuhn, Aline Rimoldi Ribeiro, Leoš Shivaya Valášek, Yaser Hashem
Published in: Cell Reports, Issue 33/12, 2020, Page(s) 108534, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.108534

Structural Insights into the Mammalian Late-Stage Initiation Complexes

Author(s): Angelita Simonetti, Ewelina Guca, Anthony Bochler, Lauriane Kuhn, Yaser Hashem
Published in: Cell Reports, Issue 31/1, 2020, Page(s) 107497, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.03.061

The Jigsaw Puzzle of mRNA Translation Initiation in Eukaryotes: A Decade of Structures Unraveling the Mechanics of the Process

Author(s): Yaser Hashem, Joachim Frank
Published in: Annual Review of Biophysics, Issue 47/1, 2018, Page(s) 125-151, ISSN 1936-122X
Publisher: Annual Reviews, Inc.
DOI: 10.1146/annurev-biophys-070816-034034

Specific features and assembly of the plant mitochondrial complex I revealed by cryo-EM

Author(s): Heddy Soufari, Camila Parrot, Lauriane Kuhn, Florent Waltz, Yaser Hashem
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-18814-w

Cryo-EM structure of the RNA-rich plant mitochondrial ribosome

Author(s): Florent Waltz, Heddy Soufari, Anthony Bochler, Philippe Giegé, Yaser Hashem
Published in: Nature Plants, Issue 6/4, 2020, Page(s) 377-383, ISSN 2055-0278
Publisher: PNG
DOI: 10.1038/s41477-020-0631-5

Non-peer reviewed articles (2)

Major structural rearrangements of the canonical eukaryotic translation initiation complex

Author(s): Ewelina Guca, Yaser Hashem
Published in: Current Opinion in Structural Biology, Issue 53, 2018, Page(s) 151-158, ISSN 0959-440X
Publisher: Elsevier BV
DOI: 10.1016/j.sbi.2018.08.006

Specificities of the plant mitochondrial translation apparatus

Author(s): Florent Waltz, Nicolas Corre, Yaser Hashem, Philippe Giegé
Published in: Mitochondrion, Issue 53, 2020, Page(s) 30-37, ISSN 1567-7249
Publisher: Elsevier BV
DOI: 10.1016/j.mito.2020.04.008