Periodic Reporting for period 4 - SEC (Stereoretentive-Enantioconvergent Catalysis: A New Concept in Asymmetric Synthesis)
Reporting period: 2022-05-01 to 2023-04-30
The overall objective of this project is to establish a conceptually new stereoretentive-dimerisation approach that results in both enantiomers of the starting material being incorporated into the product with no de-racemisation required. This new concept will prove highly valuable for the synthesis of small enantiopure building blocks, which will be of high value in many areas of synthesis, and also for more complex late-stage transformations in complex molecule synthesis. Several approaches will be pursued to demonstrate proof-of-principle, and applications in the synthesis of complex natural and unnatural products will then be used to demonstrate the potential of stereoretentive-enantioconvergent catalysis in target-orientated synthesis.