Objective
Hypertension (HTN) is a leading cause of morbidity and mortality worldwide. During past decades, several therapies have been developed to afford an optimal blood pressure (BP) regulation. However, the prevalence of uncontrolled HTN continues to rise, with a number of patients still resistant to all ongoing antihypertensive treatments, raising unsolved mechanistic challenges. In the last years, the most attractive novelty in HTN postulated that immune system has a crucial role in BP raising, as well as in end-organ damage. Several advances have been done in this field, but clear mechanistic explanations of how the immune system gets activated under hypertensive challenges is still unknown. It is becoming increasingly clear that, even in the regulation of body hemodynamic, the immune system and the autonomic nervous system serve as two major “sensory organs” capable to be activated upon manifold hits that perturb homeostasis. SymPAtHY is a multidisciplinary strategy aimed at discovering how nervous and immune systems couple in HTN. The concept of this project is to dissect the neuro-immune pathway responsible for BP rising and end-organ damage. The articulation in 3 MAIN AIMS will allow to afford the mechanistic insights from different perspectives. The overall objectives are as follows: 1) Central nervous system relay station coupling immunity and hypertension. 2) Splenic immune mechanisms: from sympathetic drive to T cell egress; 3) T cells in target organs: from the spleen to vessels and kidney. The results of this strategy will unravel important new mechanistic insights in HTN and particularly will have significant implications for understanding how immunity and autonomic nervous system cooperate to rise BP. Based on the emerging view of HTN as an “immune disorder”, we believe that this strategy will add decisive knowledge in this field that could pave the way for developing immunotherapies for the treatment of resistant HTN.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- natural sciences biological sciences neurobiology
- social sciences sociology demography mortality
- medical and health sciences basic medicine immunology immunotherapy
- medical and health sciences basic medicine physiology homeostasis
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Keywords
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Project’s keywords as indicated by the project coordinator. Not to be confused with the EuroSciVoc taxonomy (Fields of science)
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
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H2020-EU.1.1. - EXCELLENT SCIENCE - European Research Council (ERC)
MAIN PROGRAMME
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Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
ERC-STG - Starting Grant
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Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
(opens in new window) ERC-2017-STG
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Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.
00185 Roma
Italy
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.