Periodic Reporting for period 1 - GAIT (From symptom relief to disease modifying allergy treatment with Glycan-Allergen Immunotherapy)
Reporting period: 2017-03-01 to 2017-08-31
DC4U is developing a new generation of disease modifying allergy treatment with the potential to replace symptom relieving products and current AIT. We apply a new and unique technology to present allergens to the immune system as being SELF and SAFE, using glycans as endogenous human protein recognition elements. Our lead product, “sia-GP”, is a grass pollen allergy treatment for life long protection, achieved in a short treatment course. The overall objective is to develop this proprietary product up to and including Phase IIa clinical trials, followed by out-licensing it as a risk-reduced asset to a pharmaceutical company. This will generate early stage income by milestone payments and royalties to fund other pipeline products. Allergy patients represent the end-user group of our product. Effective curative tolerance inducing therapy will contribute to global medical needs and reduction of healthcare costs.
Our strategy is to establish early stage industrial collaborations with companies that are actively developing allergen based product. These collaborations will pave the way to strategic alliances, licensing agreements and generating joint IP with these companies. In these early stage development projects with industrial partners, the partners either contribute for a large share to the development costs or become partner in a subsidized project. In these projects we aim for preclinical proof-of-concept for the cancer vaccine application and for the allergy applications. Follow-up early stage development with early stage partners will be settled in a R&D/IP contract, where funding is based on a cost-plus model. In this model the industrial partner bears the cost for further development plus an additional payment to allow revenues. Reimbursement schedules will differ for each contract, depending on the stage of development, further development program, type of end product envisioned and the negotiation position of the parties.
The early stage collaboration with prospective clients will contribute to an important early cash flow through revenues from upfront payments and success milestones, related to the phasing fo the development process. Proceeds will be employed to further expand the DC4U's GlycoDC technology, to fund new allergy pipeline applications and the growth of the company with respect to number of employees and expand the research laboratories.