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Neuroimmune activation as a novel therapeutic approach for IBD

Objective

NeurIMM has been designed to investigate the commercial and technical viability of a novel, targeted therapy for Inflammatory Bowel Disease (IBD), based on a recently uncovered signaling axis between intestinal type 3 innate lymphoid cells (ILC3s) and enteric glial cells. This discovery by the team of Prof. Henrique Veiga-Fernandes in the ERC CoG grant 647274 ‘GliaInnateSensing’ was recently published in Nature (Ibiza et al, Nature 2016). NeurIMM proposes the use of a glial cell-derived immunomodulator to restore intestinal homeostasis, by inducing a tissue protective immune response. Importantly, this novel therapy will also promote tissue healing to reverse immune-cell mediated tissue damage, leading to improved outcomes for the patient. This could have major implications for patients suffering from IBD. In addition, this approach also has potential as an effective therapy against cancer, (pediatric) gastroenteritis, and other inflammatory disorders.

Field of science

  • /medical and health sciences/basic medicine/physiology/homeostasis
  • /medical and health sciences/clinical medicine/oncology/cancer
  • /medical and health sciences/clinical medicine/gastroenterology/inflammatory bowel disease

Call for proposal

ERC-2017-PoC
See other projects for this call

Funding Scheme

ERC-POC - Proof of Concept Grant

Host institution

FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
Address
Avenida Brasilia, Centro De Investigacao Da Fundacao Champalimaud
1400-038 Lisboa
Portugal
Activity type
Research Organisations
EU contribution
€ 150 000

Beneficiaries (1)

FUNDACAO D. ANNA SOMMER CHAMPALIMAUD E DR. CARLOS MONTEZ CHAMPALIMAUD
Portugal
EU contribution
€ 150 000
Address
Avenida Brasilia, Centro De Investigacao Da Fundacao Champalimaud
1400-038 Lisboa
Activity type
Research Organisations