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Delivering Better Starting Points for Drug Discovery: New Compound Libraries Driven By Intelligent Design

Objective

Whilst the need to generate new therapeutics has never been more important, drug discovery is at the same time becoming much more difficult. In short, we need to be more efficient at developing drugs. One way of achieving this is to reduce the attrition rates, which currently blight the drug-discovery process, by populating compound screening libraries with more structurally diverse and higher quality, i.e. designed, molecules to provide better starting points for drug development. Pharma also needs a new type of researcher given an increasing proportion of scientists are now finding employment in smaller companies, where they need to be more flexible, entrepreneurial and business-aware. iDESIGN seeks to address these key challenges by combining the complementary expertise from both academic and industrial sectors. iDESIGN has the following Principal Objectives: 1) to use the ESRs' individual research projects to develop new, structurally diverse, 'smart' compound libraries for the sector to use in hit-identification screening campaigns; 2) to provide a training programme which will see the ESRs becoming expert synthetic and medicinal chemists, confident research scientists, consummate professionals, effective communicators and innovators with a creative and entrepreneurial spirit. iDESIGN will begin with an academic training phase, during which the ESRs will undertake project-wide training whilst acquiring the synthesis skills to generate bespoke molecular scaffolds, which they will elaborate and validate using in silico and experimental methods. The ESRs will then transfer to one of the industrial partners to take full advantage of their Industrial Supervisors' expertise and the available instrumentation to complete the library-generation aspect of their research projects. All 6 ESRs will return to Birmingham for their final 2 months to allow their Academic Supervisors to oversee directly the final stages of their PhD thesis preparation.

Coordinator

THE UNIVERSITY OF BIRMINGHAM
Net EU contribution
€ 622 489,06
Address
Edgbaston
B15 2TT Birmingham
United Kingdom

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Region
West Midlands (England) West Midlands Birmingham
Activity type
Higher or Secondary Education Establishments
Non-EU contribution
€ 0,00

Participants (2)

ANALYTICON DISCOVERY GMBH
Germany
Net EU contribution
€ 318 443,28
Address
Hermannswerder Haus 17
14473 Potsdam

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Region
Brandenburg Brandenburg Potsdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
MERCACHEM BV
Netherlands
Net EU contribution
€ 624 248,24
Address
Kerkenbos 1013
6546BB Nijmegen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00

Partners (3)

Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

Apconix
United Kingdom
Net EU contribution
€ 0,00
Address
Alderley Park
Sk10 4TG Alderley

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Region
North West (England) Cheshire Cheshire East
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MERCALEADS BV
Netherlands
Net EU contribution
€ 0,00
Address
Kerkenbos 1013
6546 BB Nijmegen

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SME

The organization defined itself as SME (small and medium-sized enterprise) at the time the Grant Agreement was signed.

Yes
Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00
Partner

Partner organisations contribute to the implementation of the action, but do not sign the Grant Agreement.

MERCATORIAL BV
Netherlands
Net EU contribution
€ 0,00
Address
Kerkenbos 1013
6546 BB Nijmegen

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Region
Oost-Nederland Gelderland Arnhem/Nijmegen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
Non-EU contribution
€ 0,00