COmbatting disorders of adaptive immunity with Systems MedICine

Deliverables

Websites, patent fillings, videos etc. (1)

Initial setup of external website, Facebook, Twitter, etc

Initial setup of external website, Facebook, Twitter, etc

Documents, reports (3)

Plan for dissemination strategy

Plan for dissemination strategy

1. Mechanistic models of GCR in BCN/RA

Publications and Open Source software regarding mechanistic B/T cell-based models of GCR in BCN/RA. (M24 and M42) Publication and Open Source software regarding mechanistic molecular network GCR models (M24, M42)

1. Dissemination reports

Dissemination reports (M24,38,48) This will include information about: -Science Cafes, patient seminars -Education secondary school completed -8 COSMIC Newsletters -Data, software, education material available -(White) paper best practices systems medicine

Other (4)

Collection and review of all ethical approvals

Collection and review of all ethical approvals

1. Quantitative/single cell/molecular data of the GCR

Publications and Open Access data regarding. Quantitative and temporal data of the normal GCR. (M24) Publications and Open Access data regarding (Single cell) molecular signatures (transcriptomics, ChipSeq, ATACseq). (M24, M42)

Vacancies, Recruitment, Declarations on conformity

Advertise positions; Recruit ESRs. Declarations on conformity.

Supervisory board of COSMIC

Supervisory Board of COSMIC installed

Publications

Peer reviewed articles (4)

Computational Model Reveals a Stochastic Mechanism behind Germinal Center Clonal Bursts

Author(s): Aurélien Pélissier, Youcef Akrout, Katharina Jahn , Jack Kuipers , Ulf Klein , Niko Beerenwinkel, María Rodríguez Martínez 
Published in: Cells, Issue 9/6, 2020, Page(s) 1448, ISSN 2073-4409
DOI: 10.3390/cells9061448

B Cell Receptor Immunogenetics in B Cell Lymphomas: Immunoglobulin Genes as Key to Ontogeny and Clinical Decision Making

Author(s): Katerina Gemenetzi, Andreas Agathangelidis, Laura Zaragoza-Infante, Electra Sofou, Maria Papaioannou, Anastasia Chatzidimitriou, Kostas Stamatopoulos
Published in: Frontiers in Oncology, Issue 10, 2020, ISSN 2234-943X
DOI: 10.3389/fonc.2020.00067

Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses

Author(s): Theinmozhi Arulraj, Sebastian C. Binder, Philippe A. Robert, Michael Meyer-Hermann
Published in: Frontiers in Immunology, Issue 10, 2019, ISSN 1664-3224
DOI: 10.3389/fimmu.2019.02116

In-silico simulated prototype-patients using TPMS technology to study a potential adverse effect of sacubitril and valsartan

Author(s): Guillem Jorba, Joaquim Aguirre-Plans, Valentin Junet, Cristina Segú-Vergés, José Luis Ruiz, Albert Pujol, Narcís Fernández-Fuentes, José Manuel Mas, Baldo Oliva
Published in: PLOS ONE, Issue 15/2, 2020, Page(s) e0228926, ISSN 1932-6203
DOI: 10.1371/journal.pone.0228926

Other (2)

TPMS technology to infer biomarkers of macular degeneration prognosis in in silico simulated prototype-patients under the study of heart failure treatment with sacubitril and valsartan

Author(s): Jorba, Guillem; Aguirre-Plans, Joaquim; Junet, Valentin; Segú-Vergés, Cristina; Ruiz, José Luis; Pujol, Albert; Fernandez-Fuentes, Narcis; Mas, José Manuel; Oliva, Baldo
Published in: bioRxiv, Issue 1, 2019
DOI: 10.1101/625889

DNA polymerase β prevents AID-instigated mutagenic non-canonical mismatch DNA repair

Author(s): Mahnoush Bahjat; Maria Stratigopoulou; Bas Pilzecker; Tijmen P. van Dam; Simon Mobach; Richard J. Bende; Carel J.M. van Noesel; Heinz Jacobs; Jeroen E.J. Guikema
Published in: bioXrive, Issue 1, 2020
DOI: 10.1101/2020.01.30.926964