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TArgeting Platelet Adhesion receptors in thrombosiS

Objective

TAPAS will position Europe at the forefront of innovative research to prevent thrombosis and thromboinflammation, and will train a uniquely-qualified cohort of ESRs in a highly intersectorial and multi-disciplinary programme that will equip them with the knowledge and transferable skills required in the broad biomedical sector. The research will focus on platelets which are small cells in the blood that play a critical role in prevention of excessive bleeding following injury (haemostasis). Activation of platelets in diseased vessels gives rise to thrombotic disorders such as heart attack and stroke, two of the major causes of morbidity and mortality. Patients at risk of thrombosis are treated with medicines that inhibit platelets for life, but many patients still undergo thrombotic episodes or encounter serious bleeds through diminished haemostasis. There is thus an urgent need for novel and safe anti-platelet medicines that powerfully target thrombosis but preserve haemostasis. In TAPAS, an original and innovative approach will be undertaken to find new ways to target thrombosis through co-operation of academic experts in distinct disciplines with key skills from the private sector. TAPAS will generate and integrate knowledge from analytical complex ‘omics’, advanced microscopy, cell biology, microfluidics, in vivo models, contemporary systems biology and high throughput screens to identify new targets for therapeutic intervention and novel lead compounds or biologics. The research skills developed in this programme are applicable to other complex diseases and represent essential training in modern day research for the next cohort of academic and private sector scientists that are able to convert complex biological understanding into new medicines. The shared knowledge and close interaction between beneficiaries and partners makes this programme ideally suited to an EJD and will deliver 15 ESRs in 21st century biomedical research.

Field of science

  • /natural sciences/biological sciences/cell biology
  • /medical and health sciences/basic medicine/neurology/stroke
  • /social sciences/sociology/demography/mortality

Call for proposal

H2020-MSCA-ITN-2017
See other projects for this call

Funding Scheme

MSCA-ITN-EJD - European Joint Doctorates

Coordinator

THE UNIVERSITY OF BIRMINGHAM
Address
Edgbaston
B15 2TT Birmingham
United Kingdom
Activity type
Higher or Secondary Education Establishments
EU contribution
€ 546 575,76

Participants (6)

UNIVERSITEIT MAASTRICHT
Netherlands
EU contribution
€ 1 021 497,12
Address
Minderbroedersberg 4-6
6200 MD Maastricht
Activity type
Higher or Secondary Education Establishments
THE UNIVERSITY OF READING
United Kingdom
EU contribution
€ 819 863,64
Address
Whiteknights Campus Whiteknights House
RG6 6AH Reading
Activity type
Higher or Secondary Education Establishments
LEIBNIZ-INSTITUT FUR ANALYTISCHE WISSENSCHAFTEN-ISAS-EV
Germany
EU contribution
€ 498 432,96
Address
Bunsen Kirchhoff Strasse 11
44139 Dortmund
Activity type
Research Organisations
UNIVERSITAETSKLINIKUM WUERZBURG - KLINIKUM DER BAYERISCHEN JULIUS-MAXIMILIANS-UNIVERSITAT
Germany
EU contribution
€ 498 432,96
Address
Josef-schneider-strasse 2
97080 Wurzburg
Activity type
Higher or Secondary Education Establishments
ALACRIS THERANOSTICS GMBH
Germany
EU contribution
€ 249 216,48
Address
Max Planck Strasse 3
12489 Berlin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
UNIVERSIDAD DE SANTIAGO DE COMPOSTELA
Spain
EU contribution
€ 247 872,96
Address
Colexio De San Xerome Praza Do Obradoiro S/n
15782 Santiago De Compostela
Activity type
Higher or Secondary Education Establishments

Partners (6)

Nikon Instruments Europe
Netherlands
Address
Burgerweeshuispad 101
1076ER Amsterdam
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
SEMMELWEIS EGYETEM
Hungary
Address
Ulloi Utca 26
1085 Budapest
Activity type
Higher or Secondary Education Establishments
SVEUCILISTE U RIJECI
Croatia
Address
Trg Brace Mazuranica 10
51000 Rijeka
Activity type
Higher or Secondary Education Establishments
Intelligent Imaging Innovations GmbH
Germany
Address
Königsallee 9-21
D-37081 Göttingen
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
CELLIX LIMITED
Ireland
Address
Long Mile Road Unit 1
12 Dublin
Activity type
Private for-profit entities (excluding Higher or Secondary Education Establishments)
PIVOT PARK SCREENING CENTRE BV
Netherlands
Address
Kloosterstraat 9
5349 AB Oss
Activity type
Research Organisations