Mechanisms of stem cell population dynamics and reprogramming

Project Information

STEMpop

Grant agreement ID: 770877

DOI 10.3030/770877

Project closed

EC signature date 13 February 2018

Start date 1 May 2018

End date 31 October 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 918,00

EU contribution € 1 999 918,00

Coordinated by

HELSINGIN YLIOPISTO
Finland

Publications

Peer reviewed articles (6)

Glutamine Metabolism Controls Stem Cell Fate Reversibility and Long-Term Maintenance in the Hair Follicle

Author(s): Christine S. Kim, Xiaolei Ding, Kira Allmeroth, Leah C. Biggs, Olivia I. Kolenc, Nina L’Hoest, Carlos Andrés Chacón-Martínez, Christian Edlich-Muth, Patrick Giavalisco, Kyle P. Quinn, Martin S. Denzel, Sabine A. Eming, Sara A. Wickström
Published in: Cell Metabolism, Issue 32/4, 2020, Page(s) 629-642.e8, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.08.011

Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage

Author(s): Michele M. Nava, Yekaterina A. Miroshnikova, Leah C. Biggs, Daniel B. Whitefield, Franziska Metge, Jorge Boucas, Helena Vihinen, Eija Jokitalo, Xinping Li, Juan Manuel García Arcos, Bernd Hoffmann, Rudolf Merkel, Carien M. Niessen, Kris Noel Dahl, Sara A. Wickström
Published in: Cell, Issue 181/4, 2020, Page(s) 800-817.e22, ISSN 0092-8674
Publisher: Cell Press
DOI: 10.1016/j.cell.2020.03.052

Epigenetic gene regulation, chromatin structure, and force-induced chromatin remodelling in epidermal development and homeostasis

Author(s): Yekaterina A Miroshnikova, Idan Cohen, Elena Ezhkova, Sara A Wickström
Published in: Current Opinion in Genetics & Development, Issue 55, 2019, Page(s) 46-51, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2019.04.014

Mechanical Forces in the Skin: Roles in Tissue Architecture, Stability, and Function

Author(s): Leah C. Biggs, Christine S. Kim, Yekaterina A. Miroshnikova, Sara A. Wickström
Published in: Journal of Investigative Dermatology, 2019, ISSN 0022-202X
Publisher: Blackwell Publishing Inc.
DOI: 10.1016/j.jid.2019.06.137

Niche stiffening compromises hair follicle stem cell potential during ageing by reducing bivalent promoter accessibility

Author(s): Janis Koester, Yekaterina A. Miroshnikova, Sushmita Ghatak, Carlos Andrés Chacón-Martínez, Jessica Morgner, Xinping Li, Ilian Atanassov, Janine Altmüller, David E. Birk, Manuel Koch, Wilhelm Bloch, Michaela Bartusel, Carien M. Niessen, Alvaro Rada-Iglesias, Sara A. Wickström
Published in: Nature Cell Biology, Issue 23, 2021, ISSN 1476-4679
Publisher: Nature Publishing Group
DOI: 10.1038/s41556-021-00705-x

Somatic Niche Cells Regulate the CEP-1/p53-Mediated DNA Damage Response in Primordial Germ Cells

Author(s): Hui-Ling Ou, Christine S. Kim, Simon Uszkoreit, Sara A. Wickström, Björn Schumacher
Published in: Developmental Cell, Issue 50/2, 2019, Page(s) 167-183.e8, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2019.06.012