Phenotype switching: plasticity and/or differentiation of stromal cells and their progenitors within the tumour microenvironment regulate tumour fate.

Project Information

PhenoSwitch

Grant agreement ID: 771112

DOI 10.3030/771112

Project closed

EC signature date 13 March 2018

Start date 1 April 2018

End date 31 March 2023

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 906 250,00

EU contribution € 1 906 250,00

Coordinated by

TECHNION - ISRAEL INSTITUTE OF TECHNOLOGY
Israel

Publications

Peer reviewed articles (12)

Immunostimulatory and anti-tumor metronomic cyclophosphamide regimens assessed in primary orthotopic and metastatic murine breast cancer

Author(s): Kabir A. Khan, José L. Ponce de Léon, Madeleine Benguigui, Ping Xu, Annabelle Chow, William Cruz-Muñoz, Shan Man, Yuval Shaked, Robert S. Kerbel
Published in: npj Breast Cancer, Issue 6/1, 2020, ISSN 2374-4677
Publisher: NPH Breast Cancer
DOI: 10.1038/s41523-020-0171-1

IL-31 induces antitumor immunity in breast carcinoma

Author(s): Tal Kan, Erik Feldman, Michael Timaner, Ziv Raviv, Shai Shen-Orr, Ami Aronheim, Yuval Shaked
Published in: Journal for ImmunoTherapy of Cancer, Issue 8/2, 2020, Page(s) e001010, ISSN 2051-1426
Publisher: Journal of Immunotherapy of Cancer
DOI: 10.1136/jitc-2020-001010

The Potential Role of Immune Alteration in the Cancer–COVID19 Equation—A Prospective Longitudinal Study

Author(s): Tal Goshen-Lago, Moran Szwarcwort-Cohen, Madeleine Benguigui, Ronit Almog, Ilit Turgeman, Nelly Zaltzman, Michael Halberthal, Yuval Shaked, Irit Ben-Aharon
Published in: Cancers, Issue 12/9, 2020, Page(s) 2421, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers12092421

Proinflammatory Macrophages Promote Multiple Myeloma Resistance to Bortezomib Therapy

Author(s): Ofrat Beyar-Katz, Ksenia Magidey, Anat Reiner-Benaim, Noga Barak, Irit Avivi, Yael Cohen, Michael Timaner, Shimrit Avraham, Michal Hayun, Noa Lavi, Marina Bersudsky, Elena Voronov, Ron N. Apte, Yuval Shaked
Published in: Molecular Cancer Research, Issue 17/11, 2019, Page(s) 2331-2340, ISSN 1541-7786
Publisher: American Association for Cancer Research
DOI: 10.1158/1541-7786.mcr-19-0487

The pro-tumorigenic host response to cancer therapies

Author(s): Yuval Shaked
Published in: Nature Reviews Cancer, Issue 19/12, 2019, Page(s) 667-685, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-019-0209-6

Elucidating the roles of ASPM isoforms reveals a novel prognostic marker for pancreatic cancer

Author(s): Michael Timaner, Yuval Shaked
Published in: The Journal of Pathology, 2019, ISSN 0022-3417
Publisher: John Wiley & Sons Inc.
DOI: 10.1002/path.5355

The multifaceted role of mesenchymal stem cells in cancer

Author(s): Michael Timaner, Kelvin K Tsai, Yuval Shaked
Published in: Seminars in Cancer Biology, 2019, ISSN 1044-579X
Publisher: Academic Press
DOI: 10.1016/j.semcancer.2019.06.003

Next Viable Routes to Targeting Pancreatic Cancer Stemness: Learning from Clinical Setbacks

Author(s): Kelvin K. Tsai, Tze-Sian Chan, Yuval Shaked
Published in: Journal of Clinical Medicine, Issue 8/5, 2019, Page(s) 702, ISSN 2077-0383
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/jcm8050702

Microparticles from tumors exposed to radiation promote immune evasion in part by PD-L1

Author(s): Michael Timaner, Ruslana Kotsofruk, Ziv Raviv, Ksenia Magidey, Dvir Shechter, Tal Kan, Alexander Nevelsky, Shahar Daniel, Elisabeth G. E. de Vries, Tongwu Zhang, Orit Kaidar-Person, Robert S. Kerbel, Yuval Shaked
Published in: Oncogene, 2019, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-019-0971-7

ATF3 and JDP2 deficiency in cancer associated fibroblasts promotes tumor growth via SDF-1 transcription

Author(s): Shimrit Avraham, Ben Korin, Sharon Aviram, Dvir Shechter, Yuval Shaked, Ami Aronheim
Published in: Oncogene, Issue 38/20, 2019, Page(s) 3812-3823, ISSN 0950-9232
Publisher: Nature Publishing Group
DOI: 10.1038/s41388-019-0692-y

Early Cardiac Remodeling Promotes Tumor Growth and Metastasis

Author(s): Shimrit Avraham, Soraya Abu-Sharki, Rona Shofti, Tali Haas, Ben Korin, Roy Kalfon, Tom Friedman, Avinoam Shiran, Walid Saliba, Yuval Shaked, Ami Aronheim
Published in: Circulation, Issue 142/7, 2020, Page(s) 670-683, ISSN 0009-7322
Publisher: Lippincott Williams & Wilkins Ltd.
DOI: 10.1161/circulationaha.120.046471

Breast Cancer-Derived Microparticles Reduce Cancer Cell Adhesion, an Effect Augmented by Chemotherapy

Author(s): Dvir Shechter, Michal Harel, Abhishek Mukherjee, Leonel M. Sagredo, David Loven, Elad Prinz, Shimrit Avraham, Veronique Orian-Rousseau, Tamar Geiger, Yuval Shaked, Haguy Wolfenson
Published in: Cells, Issue 9/10, 2020, Page(s) 2269, ISSN 2073-4409
Publisher: Cells
DOI: 10.3390/cells9102269