Feeling Polarity: Integrating intracellular mechanics and forces for a biophysical understanding of epithelial polarity

Project Information

PolarizeMe

Grant agreement ID: 771201

DOI

10.3030/771201

Project closed

EC signature date 7 February 2018

Start date 1 March 2018

End date 31 August 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 995 564,00

EU contribution

€ 1 995 564,00

Coordinated by

GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS
Germany

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (25)

Self-organization: the fundament of cell biology

Author(s): Roland Wedlich-Söldner, Timo Betz
Published in: Phil. Trans. R. Soc. B, Issue 373 81747), 2018, Page(s) 20170103, ISSN 0962-8436
Publisher: Royal Society of London
DOI: 10.1098/rstb.2017.0103

Cortical cell stiffness is independent of substrate mechanics

Author(s): Johannes Rheinlaender, Andrea Dimitracopoulos, Bernhard Wallmeyer, Nils M. Kronenberg, Kevin J. Chalut, Malte C. Gather, Timo Betz, Guillaume Charras, Kristian Franze
Published in: Nature Materials, Issue 19/9, 2020, Page(s) 1019-1025, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-020-0684-x

Analysis of monocyte cell tractions in 2.5D reveals mesoscale mechanics of podosomes during substrate-indenting cell protrusion

Author(s): Hendrik Schürmann, Fatemeh Abbasi, Antonella Russo, Arne D. Hofemeier, Matthias Brandt, Johannes Roth, Thomas Vogl, Timo Betz
Published in: Journal of Cell Science, Issue 135(10), 2022, Page(s) jcs259042, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.259042

Characterizing intracellular mechanics via optical tweezers-based microrheology

Author(s): Bart E. Vos, Till M. Muenker, Timo Betz
Published in: Current Opinion in Cell Biology, Issue 88, 2024, Page(s) 102374, ISSN 0955-0674
Publisher: Elsevier BV
DOI: 10.1016/j.ceb.2024.102374

Accessing activity and viscoelastic properties of artificial and living systems from passive measurement

Author(s): Till M. Muenker, Gabriel Knotz, Matthias Krüger, Timo Betz
Published in: Nature Materials, Issue 23, 2024, Page(s) 1283-1291, ISSN 1476-1122
Publisher: Nature Publishing Group
DOI: 10.1038/s41563-024-01957-2

Intracellular softening and increased viscoelastic fluidity during division

Author(s): Hurst S., Vos B., Brandt M., Betz T.
Published in: Nature Physics, Issue 17, 2021, Page(s) 1270-1276, ISSN 1745-2473
Publisher: Nature Publishing Group
DOI: 10.1038/s41567-021-01368-z

Membrane Tension Regulation is Required for Wound Repair

Author(s): Nikita Raj, Martin S. Weiß, Bart E. Vos, Sarah Weischer, Frauke Brinkmann, Timo Betz, Britta Trappmann, Volker Gerke
Published in: Advanced Science, 2024, Page(s) 2402317, ISSN 2198-3844
Publisher: Wiley-VCH GmbH
DOI: 10.1002/advs.202402317

Fluctuations of a Membrane Nanotube Covered with an Actin Sleeve.

Author(s): Allard, A., Valentino, F., Sykes, C., Betz, T., Campillo, C.
Published in: Phys Rev. E., Issue 102(5), 2020, Page(s) 052402, ISSN 2470-0053
Publisher: American Physics Society
DOI: 10.1103/physreve.102.052402

Actin modulates shape and mechanics of tubular membranes

Author(s): A. Allard, M. Bouzid, T. Betz, C. Simon, M. Abou-Ghali, J. Lemière, F. Valentino, J. Manzi, F. Brochard-Wyart, K. Guevorkian, J. Plastino, M. Lenz, C. Campillo, C. Sykes
Published in: Science Advances, Issue 6/17, 2020, Page(s) eaaz3050, ISSN 2375-2548
Publisher: AAAS
DOI: 10.1126/sciadv.aaz3050

Pressure Drives Rapid Burst-Like Coordinated Cellular Motion from 3D Cancer Aggregates

Author(s): Raghuraman, S., Schubert, A.-S., Bröker, S., Jurado, A., Müller, A., Brandt, M., Vos, B.E., Hofemeier, A.D., Abbasi, F., Stehling, M., Wittkowski, R., Ivaska, J., Betz, T.
Published in: Advanved Science, Issue 9, 2022, Page(s) 2270037, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202270037

E-cadherin focuses protrusion formation at the front of migrating cells by impeding actin flow

Author(s): Cecilia Grimaldi, Isabel Schumacher, Aleix Boquet-Pujadas, Katsiaryna Tarbashevich, Bart Eduard Vos, Jan Bandemer, Jan Schick, Anne Aalto, Jean-Christophe Olivo-Marin, Timo Betz, Erez Raz
Published in: Nature Communications, Issue 11, 2020, Page(s) 5397, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-19114-z

Human endothelial cells display a rapid tensional stress increase in response to tumor necrosis factor-alpha

Author(s): Matthias Brandt,Volker Gerke,Timo Betz
Published in: PLoS ONE, Issue 17(6), 2022, Page(s) e0270197, ISSN 1932-6203
Publisher: Public Library of Science
DOI: 10.1371/journal.pone.0270197

Variance sum rule for entropy production

Author(s): I. Di Terlizzi, M. Gironella, D. Herraez-Aguilar, T. Betz, F. Monroy, M. Baiesi, F. Ritort
Published in: Science, Issue 383, 2024, Page(s) 971-976, ISSN 0036-8075
Publisher: American Association for the Advancement of Science
DOI: 10.1126/science.adh1823

Nonswelling and Hydrolytically Stable Hydrogels Uncover Cellular Mechanosensing in 3D

Author(s): Long, H., Vos, B.E., Betz, T., Baker, B.M., Trappmann, B.,
Published in: Advanced Science, 2022, Page(s) 2105325, ISSN 2198-3844
Publisher: Wiley
DOI: 10.1002/advs.202105325

Microchip based microrheology via Acoustic Force Spectroscopy shows that endothelial cell mechanics follows a fractional viscoelastic model

Author(s): Alfred Nguyen, Matthias Brandt, Timo Betz
Published in: Lab on a Chip, Issue 10, 2021, ISSN 1473-0197
Publisher: Royal Society of Chemistry
DOI: 10.1039/d0lc01135e

Chemokine-biased robust self-organizing polarization of migrating cells in vivo.

Author(s): Olguin-Olguin, A., Aalto, A., Maugis, B., Boquet-Pujadas, A., Hofmann, D., Ermlich, L., Betz, T., Gov, N.S., Reichman-Fried, M., Raz, E.
Published in: PNAS, Issue 118(7), 2021, Page(s) e2018480118, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2018480118

Designing a high-resolution, LEGO-based microscope for an educational setting

Author(s): Vos BE, Betz Blesa E, Betz T.
Published in: The Biophysicist, Issue 2, 2021, Page(s) 29-40, ISSN 2578-6970
Publisher: Allen Press
DOI: 10.35459/tbp.2021.000191

Global and local tension measurements in biomimetic skeletal muscle tissues reveals early mechanical homeostasis

Author(s): Hofemeier, A.D., Limon, T., Muenker, T.M., Wallmeyer, B., Jurado, A., Afshar, M.E., Ebrahimi, M., Tsukanov, R., Oleksiievets, N., Enderlein, J., Gilbert, P.M., Betz, T.
Published in: eLife, Issue 10, 2021, Page(s) e60145, ISSN 2050-084X
Publisher: eLife Sciences Publications
DOI: 10.7554/elife.60145

Roadmap for Optical tweezers

Author(s): Giovanni Volpe, Onofrio M Maragò, Halina Rubinsztein-Dunlop, Giuseppe Pesce, Alexander B Stilgoe, Giorgio Volpe, Georgiy Tkachenko, Viet Giang Truong, Síle Nic Chormaic, Fatemeh Kalantarifard, Parviz Elahi, Mikael Käll, Agnese Callegari, Manuel I Marqués, Antonio AR Neves, Wendel L Moreira, Adriana Fontes, Carlos L Cesar, Rosalba Saija, Abir Saidi, Paul Beck, Jörg S Eismann, Peter Banzer, Tha
Published in: JPhys Photonics, Issue 5, 2023, Page(s) 022501, ISSN 2515-7647
Publisher: IOP Publishing Ltd
DOI: 10.1088/2515-7647/acb57b

Using migrating cells as probes to illuminate features in live embryonic tissues

Author(s): Gross-Thebing, S*., Truszkowski, L*., Tenbrinck, D*+., Sánchez-Iranzo, H., Camelo, C., Westerich, K.J., Singh, A., Paul Maier, P., Prengel, J., Lange, P., Hüwel, J., Gaede, F., Sasse, R., Vos, E.B., Betz, T., Matis, M., Prevedel, R., Luschnig, S., Diz-Muñoz, A., Burger, M., Raz, E
Published in: Science Advances, Issue (6) 49,, 2020, Page(s) eabc5546., ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.abc5546

Reversible Photoresponsive Modulation of Osmotic Pressure via Macromolecular Host–Guest Interaction

Author(s): Fabian Höglsperger; Timo Betz; Bart Jan Ravoo
Published in: ACS Marco Letters, Issue 11, 2022, Page(s) 537-542, ISSN 2161-1653
Publisher: American Chemical Society
DOI: 10.1021/acsmacrolett.2c00133

Rapid and reversible optical switching of cell membrane area by an amphiphilic azobenzene.

Author(s): Fabian Höglsperger, Bart E. Vos, Arne D. Hofemeier, Maximilian D. Seyfried, Bastian Stövesand, Azadeh Alavizargar, Leon Topp, Andreas Heuer, Timo Betz,* Bart Jan Ravoo*
Published in: Nature Communications, Issue 14, 2023, Page(s) 3760, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-39032-0

Unveiling the Active Nature of Living-Membrane Fluctuations and Mechanics

Author(s): Hervé Turlier, Timo Betz
Published in: Annual Review of Condensed Matter Physics, Issue 10/1, 2019, Page(s) 213-232, ISSN 1947-5454
Publisher: Annual Reviews Inc.
DOI: 10.1146/annurev-conmatphys-031218-013757

The force loading rate drives cell mechanosensing through both reinforcement and fluidization

Author(s): Andreu, I., Falcones, B., Hurst, S., Chahare, N., Quiroga, X., Roux, A.-L.L., Kechagia, Z., Beedle, A.E.M., Elósegui-Artola, A., Trepat, X., Farré, R., Betz, T., Almendros, I., Roca-Cusachs, P.
Published in: Nature Communications, Issue 12, 2021, Page(s) 4229, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-24383-3

Active diffusion in oocytes nonspecifically centers large objects during prophase I and meiosis I

Author(s): Alexandra Colin, Gaëlle Letort, Nitzan Razin, Maria Almonacid, Wylie Ahmed, Timo Betz, Marie-Emilie Terret, Nir S. Gov, Raphaël Voituriez, Zoher Gueroui, Marie-Hélène Verlhac
Published in: The Journal of Cell Biology, Issue 219/3, 2020, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.201908195

Conference proceedings (1)

Combining light sheet microscopy and optical tweezers for simultaneous micromanipulation and 3D visualization

Author(s): Viktoria Zieger; Timo Betz; Bart Vos
Published in: Biophotonic Congress, Issue 2012, 2021, Page(s) AM2D.3
Publisher: Optica Publisher Group
DOI: 10.1364/oma.2021.am2d.3

Intellectual Property Rights

Patent (1)

DEVICE FOR AND USE OF THE DEVICE IN CULTIVATING TISSUE AND OBSERVING CONTRACTIONS OF THE TISSUE

Application/Publication number: 23 152532
Date: 2023-01-19
Applicant(s): GEORG-AUGUST-UNIVERSITAT GOTTINGEN STIFTUNG OFFENTLICHEN RECHTS