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Patient-specific treatment for Parkinson's disease using reprogrammed skin cells

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Publications

Evaluation of TH-Cre knock-in cell lines for detection and specific targeting of stem cell-derived dopaminergic neurons

Author(s): Alessandro Fiorenzano, Marcella Birtele, Jenny Nelander Wahlestedt, Malin Parmar
Published in: Heliyon, Issue 7/1, 2021, Page(s) e06006, ISSN 2405-8440
DOI: 10.1016/j.heliyon.2021.e06006

Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

Author(s): Pedro Rifes, Marc Isaksson, Gaurav Singh Rathore, Patrick Aldrin-Kirk, Oliver Knights Møller, Guido Barzaghi, Julie Lee, Kristoffer Lihme Egerod, Dylan M. Rausch, Malin Parmar, Tune H. Pers, Thomas Laurell, Agnete Kirkeby
Published in: Nature Biotechnology, Issue 38/11, 2020, Page(s) 1265-1273, ISSN 1087-0156
DOI: 10.1038/s41587-020-0525-0

Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies

Author(s): Claire Henchcliffe, Malin Parmar
Published in: Journal of Parkinson's Disease, Issue 8/s1, 2018, Page(s) S131-S137, ISSN 1877-7171
DOI: 10.3233/jpd-181488

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation

Author(s): Fredrik Nilsson, Petter Storm, Edoardo Sozzi, David Hidalgo Gil, Marcella Birtele, Yogita Sharma, Malin Parmar, Alessandro Fiorenzano
Published in: Cells, Issue 10/1, 2021, Page(s) 137, ISSN 2073-4409
DOI: 10.3390/cells10010137

Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson’s Disease

Author(s): Shelby Shrigley, Fredrik Nilsson, Bengt Mattsson, Alessandro Fiorenzano, Janitha Mudannayake, Andreas Bruzelius, Daniella Rylander Ottosson, Anders Björklund, Deirdre B. Hoban, Malin Parmar
Published in: Journal of Parkinson's Disease, Issue 11/2, 2021, Page(s) 515-528, ISSN 1877-7171
DOI: 10.3233/jpd-202366

The future of stem cell therapies for Parkinson disease

Author(s): Malin Parmar, Shane Grealish, Claire Henchcliffe
Published in: Nature Reviews Neuroscience, Issue 21/2, 2020, Page(s) 103-115, ISSN 1471-003X
DOI: 10.1038/s41583-019-0257-7

Transsynaptic tracing and its emerging use to assess graft-reconstructed neural circuits

Author(s): Andrew F. Adler, Anders Björklund, Malin Parmar
Published in: STEM CELLS, Issue 38/6, 2020, Page(s) 716-726, ISSN 1066-5099
DOI: 10.1002/stem.3166

Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force

Author(s): Malin Parmar, Olof Torper, Janelle Drouin‐Ouellet
Published in: European Journal of Neuroscience, Issue 49/4, 2019, Page(s) 463-471, ISSN 0953-816X
DOI: 10.1111/ejn.14109

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

Author(s): Andrew F. Adler, Tiago Cardoso, Sara Nolbrant, Bengt Mattsson, Deirdre B. Hoban, Ulla Jarl, Jenny Nelander Wahlestedt, Shane Grealish, Anders Björklund, Malin Parmar
Published in: Cell Reports, Issue 28/13, 2019, Page(s) 3462-3473.e5, ISSN 2211-1247
DOI: 10.1016/j.celrep.2019.08.058

Dual modulation of neuron‐specific microRNAs and the REST complex promotes functional maturation of human adult induced neurons

Author(s): Marcella Birtele, Yogita Sharma, Srisaiyini Kidnapillai, Shong Lau, Thomas B. Stoker, Roger A. Barker, Daniella Rylander Ottosson, Janelle Drouin‐Ouellet, Malin Parmar
Published in: FEBS Letters, Issue 593/23, 2019, Page(s) 3370-3380, ISSN 0014-5793
DOI: 10.1002/1873-3468.13612

Single-cell RNA sequencing reveals midbrain dopamine neuron diversity emerging during mouse brain development

Author(s): Katarína Tiklová, Åsa K. Björklund, Laura Lahti, Alessandro Fiorenzano, Sara Nolbrant, Linda Gillberg, Nikolaos Volakakis, Chika Yokota, Markus M. Hilscher, Thomas Hauling, Fredrik Holmström, Eliza Joodmardi, Mats Nilsson, Malin Parmar, Thomas Perlmann
Published in: Nature Communications, Issue 10/1, 2019, ISSN 2041-1723
DOI: 10.1038/s41467-019-08453-1

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Author(s): Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
DOI: 10.1038/s41467-020-16225-5

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD

Author(s): Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, Malin Parmar
Published in: Proceedings of the National Academy of Sciences, 2020, Page(s) 202001305, ISSN 0027-8424
DOI: 10.1073/pnas.2001305117

From Skin to Brain: A Parkinson’s Disease Patient Transplanted with His Own Cells

Author(s): Malin Parmar, Anders Björklund
Published in: Cell Stem Cell, Issue 27/1, 2020, Page(s) 8-10, ISSN 1934-5909
DOI: 10.1016/j.stem.2020.06.008

Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective

Author(s): Anders Björklund, Malin Parmar
Published in: Frontiers in Cellular Neuroscience, Issue 14, 2020, ISSN 1662-5102
DOI: 10.3389/fncel.2020.00146

Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons

Author(s): Sara Nolbrant, Jessica Giacomoni, Deirdre B. Hoban, Andreas Bruzelius, Marcella Birtele, Devin Chandler-Militello, Maria Pereira, Daniella Rylander Ottosson, Steven A. Goldman, Malin Parmar
Published in: Stem Cell Reports, 2020, ISSN 2213-6711
DOI: 10.1016/j.stemcr.2020.08.013