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Patient-specific treatment for Parkinson's disease using reprogrammed skin cells

Publications

Evaluation of TH-Cre knock-in cell lines for detection and specific targeting of stem cell-derived dopaminergic neurons

Author(s): Alessandro Fiorenzano, Marcella Birtele, Jenny Nelander Wahlestedt, Malin Parmar
Published in: Heliyon, Issue 7/1, 2021, Page(s) e06006, ISSN 2405-8440
Publisher: Heliyon
DOI: 10.1016/j.heliyon.2021.e06006

Modeling neural tube development by differentiation of human embryonic stem cells in a microfluidic WNT gradient

Author(s): Pedro Rifes, Marc Isaksson, Gaurav Singh Rathore, Patrick Aldrin-Kirk, Oliver Knights Møller, Guido Barzaghi, Julie Lee, Kristoffer Lihme Egerod, Dylan M. Rausch, Malin Parmar, Tune H. Pers, Thomas Laurell, Agnete Kirkeby
Published in: Nature Biotechnology, Issue 38/11, 2020, Page(s) 1265-1273, ISSN 1087-0156
Publisher: Nature Publishing Group
DOI: 10.1038/s41587-020-0525-0

Repairing the Brain: Cell Replacement Using Stem Cell-Based Technologies

Author(s): Claire Henchcliffe, Malin Parmar
Published in: Journal of Parkinson's Disease, Issue 8/s1, 2018, Page(s) S131-S137, ISSN 1877-7171
Publisher: IOS Press
DOI: 10.3233/jpd-181488

Generation of Human Ventral Midbrain Organoids Derived from Pluripotent Stem Cells

Author(s): Edoardo Sozzi, Fredrik Nilsson, Janko Kajtez, Malin Parmar, Alessandro Fiorenzano
Published in: Current Protocols, 2022, ISSN 2691-1299
Publisher: John Wiley & Sons, [2021]-
DOI: 10.1002/cpz1.555

Single-Cell Profiling of Coding and Noncoding Genes in Human Dopamine Neuron Differentiation

Author(s): Fredrik Nilsson, Petter Storm, Edoardo Sozzi, David Hidalgo Gil, Marcella Birtele, Yogita Sharma, Malin Parmar, Alessandro Fiorenzano
Published in: Cells, Issue 10/1, 2021, Page(s) 137, ISSN 2073-4409
Publisher: Europe PMC
DOI: 10.3390/cells10010137

Grafts Derived from an α-Synuclein Triplication Patient Mediate Functional Recovery but Develop Disease-Associated Pathology in the 6-OHDA Model of Parkinson’s Disease

Author(s): Shelby Shrigley, Fredrik Nilsson, Bengt Mattsson, Alessandro Fiorenzano, Janitha Mudannayake, Andreas Bruzelius, Daniella Rylander Ottosson, Anders Björklund, Deirdre B. Hoban, Malin Parmar
Published in: Journal of Parkinson's Disease, Issue 11/2, 2021, Page(s) 515-528, ISSN 1877-7171
Publisher: IOS Press
DOI: 10.3233/jpd-202366

The future of stem cell therapies for Parkinson disease

Author(s): Malin Parmar, Shane Grealish, Claire Henchcliffe
Published in: Nature Reviews Neuroscience, Issue 21/2, 2020, Page(s) 103-115, ISSN 1471-003X
Publisher: Nature Publishing Group
DOI: 10.1038/s41583-019-0257-7

A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants

Author(s): Patrick Aldrin-Kirk, Malin Åkerblom, Tiago Cardoso, Sara Nolbrant, Andrew F. Adler, Xiaohe Liu, Andreas Heuer, Marcus Davidsson, Malin Parmar, Tomas Björklund
Published in: Stem Cell Reports, 2022, ISSN 2629-3269
Publisher: [Totowa, N.J.] : Humana Press, [2009]-
DOI: 10.1016/j.stemcr.2021.11.014

Transsynaptic tracing and its emerging use to assess graft-reconstructed neural circuits

Author(s): Andrew F. Adler, Anders Björklund, Malin Parmar
Published in: STEM CELLS, Issue 38/6, 2020, Page(s) 716-726, ISSN 1066-5099
Publisher: AlphaMed Press Inc
DOI: 10.1002/stem.3166

Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain

Author(s): Birtele M, Storm P, Sharma Y, Kajtez J, Wahlestedt JN, Sozzi E, Nilsson F, Stott S, He XL, Mattsson B, Ottosson DR, Barker RA, Fiorenzano A, Parmar M.
Published in: Development, 2022, ISSN 0950-1991
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/dev.200504

Cell‐based therapy for Parkinson's disease: A journey through decades toward the light side of the Force

Author(s): Malin Parmar, Olof Torper, Janelle Drouin‐Ouellet
Published in: European Journal of Neuroscience, Issue 49/4, 2019, Page(s) 463-471, ISSN 0953-816X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/ejn.14109

hESC-Derived Dopaminergic Transplants Integrate into Basal Ganglia Circuitry in a Preclinical Model of Parkinson’s Disease

Author(s): Andrew F. Adler, Tiago Cardoso, Sara Nolbrant, Bengt Mattsson, Deirdre B. Hoban, Ulla Jarl, Jenny Nelander Wahlestedt, Shane Grealish, Anders Björklund, Malin Parmar
Published in: Cell Reports, Issue 28/13, 2019, Page(s) 3462-3473.e5, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2019.08.058

Single cell transcriptomics identifies stem cell-derived graft composition in a model of Parkinson’s disease

Author(s): Katarína Tiklová, Sara Nolbrant, Alessandro Fiorenzano, Åsa K. Björklund, Yogita Sharma, Andreas Heuer, Linda Gillberg, Deirdre B. Hoban, Tiago Cardoso, Andrew F. Adler, Marcella Birtele, Hilda Lundén-Miguel, Nikolaos Volakakis, Agnete Kirkeby, Thomas Perlmann, Malin Parmar
Published in: Nature Communications, Issue 11/1, 2020, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-16225-5

Impact of α-synuclein pathology on transplanted hESC-derived dopaminergic neurons in a humanized α-synuclein rat model of PD

Author(s): Deirdre B. Hoban, Shelby Shrigley, Bengt Mattsson, Ludivine S. Breger, Ulla Jarl, Tiago Cardoso, Jenny Nelander Wahlestedt, Kelvin C. Luk, Anders Björklund, Malin Parmar
Published in: Proceedings of the National Academy of Sciences, 2020, Page(s) 202001305, ISSN 0027-8424
Publisher: National Academy of Sciences
DOI: 10.1073/pnas.2001305117

Single-cell transcriptomics captures features of human midbrain development and dopamine neuron diversity in brain organoids

Author(s): Alessandro Fiorenzano, Edoardo Sozzi, Marcella Birtele, Janko Kajtez, Jessica Giacomoni, Fredrik Nilsson, Andreas Bruzelius, Yogita Sharma, Yu Zhang, Bengt Mattsson, Jenny Emnéus, Daniella Rylander Ottosson, Petter Storm, Malin Parmar
Published in: Nat Commun, 2021, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-27464-5

Silk scaffolding drives self-assembly of functional and mature human brain organoids

Author(s): Edoardo Sozzi, Janko Kajtez, Andreas Bruzelius, Milan Finn Wesseler, Fredrik Nilsson, Marcella Birtele, Niels B. Larsen, Daniella Rylander Ottosson, Petter Storm, Malin Parmar, Alessandro Fiorenzano
Published in: Frontiers in cell and developmental biology, 2022, ISSN 2410-3896
Publisher: Frontiers Media S.A., 2013-
DOI: 10.3389/fcell.2022.1023279

Preclinical quality, safety, and efficacy of a human embryonic stem cell-derived product for the treatment of Parkinson's disease, STEM-PD

Author(s): Agnete Kirkeby, Jenny Nelander, Deirdre B. Hoban, Nina Rogelius, Hjalmar Bjartmarz, Novo Nordisk Cell Therapy R&D, Petter Storm, Alessandro Fiorenzano, Andrew F. Adler, Shelby Vale, Janitha Mudannayake, Yu Zhang, Tiago Cardoso, Bengt Mattsson, Anne M. Landau, Andreas N. Glud, Jens C. Sørensen, Thea P. Lillethorup, Mark Lowdell, Carla Carvalho, Owen Bain, Trinette van Vliet, Olle Lindvall, Anders
Published in: Cell Stem Cell, 2023, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2023.08.014

From Skin to Brain: A Parkinson’s Disease Patient Transplanted with His Own Cells

Author(s): Malin Parmar, Anders Björklund
Published in: Cell Stem Cell, Issue 27/1, 2020, Page(s) 8-10, ISSN 1934-5909
Publisher: Cell Press
DOI: 10.1016/j.stem.2020.06.008

In vivo conversion of dopamine neurons in mouse models of Parkinson’s disease — a future approach for regenerative therapy?

Author(s): Malin Parmar, Anders Björklund, Tomas Björklund
Published in: Current Opinion in Genetics & Development, Issue 70, 2021, Page(s) 76-82, ISSN 0959-437X
Publisher: Elsevier BV
DOI: 10.1016/j.gde.2021.06.002

Age-related pathological impairments in directly reprogrammed dopaminergic neurons derived from patients with idiopathic Parkinson’s disease

Author(s): Janelle Drouin-Ouellet, Emilie M Legault, Fredrik Nilsson, Karolina Pircs, Julie Bouquety, Florence Petit, Shelby Shrigley, Marcella Birtele, Maria Pereira, Petter Storm, Yogita Sharma, Andreas Bruzelius, Romina Vuono, Malin Kele, Thomas B Stoker, Daniella Rylander Ottosson, Anna Falk, Johan Jakobsson, Roger A Barker, Malin Parmar
Published in: Stem Cell Reports, 2022, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2022.08.010

Deconvolution of spatial sequencing provides accurate characterization of hESC-derived DA transplants in vivo

Author(s): Jana Rájová, Marcus Davidsson, Martino Avallone, Morgan Hartnor, Patrick Aldrin-Kirk, Tiago Cardoso, Sara Nolbrant, Annelie Mollbrink, Petter Storm, Andreas Heuer, Malin Parmar, Tomas Björklund
Published in: Molecular therapy. Methods & clinical development, 2023, ISSN 2329-0501
Publisher: Nature Publishing Group
DOI: 10.1016/j.omtm.2023.04.008

Neuronal Replacement as a Tool for Basal Ganglia Circuitry Repair: 40 Years in Perspective

Author(s): Anders Björklund, Malin Parmar
Published in: Frontiers in Cellular Neuroscience, Issue 14, 2020, ISSN 1662-5102
Publisher: Frontiers Research Foundation
DOI: 10.3389/fncel.2020.00146

Direct Reprogramming of Human Fetal- and Stem Cell-Derived Glial Progenitor Cells into Midbrain Dopaminergic Neurons

Author(s): Sara Nolbrant, Jessica Giacomoni, Deirdre B. Hoban, Andreas Bruzelius, Marcella Birtele, Devin Chandler-Militello, Maria Pereira, Daniella Rylander Ottosson, Steven A. Goldman, Malin Parmar
Published in: Stem Cell Reports, 2020, ISSN 2213-6711
Publisher: Cell Press
DOI: 10.1016/j.stemcr.2020.08.013

In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids

Author(s): Daniel Reumann, Christian Krauditsch, Maria Novatchkova, Edoardo Sozzi, Sakurako Nagumo Wong, Michael Zabolocki, Marthe Priouret, Balint Doleschall, Kaja I. Ritzau-Reid, Marielle Piber, Ilaria Morassut, Charles Fieseler, Alessandro Fiorenzano, Molly M. Stevens, Manuel Zimmer, Cedric Bardy, Malin Parmar & Jürgen A. Knoblich
Published in: Nature Methods, 2023, ISSN 1548-7091
Publisher: Nature Publishing Group
DOI: 10.1038/s41592-023-02080-x

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