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Dynamic Activatable Fluorophores

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Publications

A Palette of Minimally Tagged Sucrose Analogues for Real‐Time Raman Imaging of Intracellular Plant Metabolism

Author(s): Fabio Moliner, Kirsten Knox, Doireann Gordon, Martin Lee, William J. Tipping, Ailsa Geddis, Anke Reinders, John M. Ward, Karl Oparka, Marc Vendrell
Published in: Angewandte Chemie International Edition, 60/14, 2021, Page(s) 7637-7642, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202016802

A fluorogenic probe for granzyme B enables in-biopsy evaluation and screening of response to anticancer immunotherapies

Author(s): Jamie I. Scott, Lorena Mendive-Tapia, Doireann Gordon, Nicole D. Barth, Emily J. Thompson, Zhiming Cheng, David Taggart, Takanori Kitamura, Alberto Bravo-Blas, Edward W. Roberts, Jordi Juarez-Jimenez, Julien Michel, Berber Piet, I. Jolanda de Vries, Martijn Verdoes, John Dawson, Neil O. Carragher, Richard A. O’ Connor, Ahsan R. Akram, Margaret Frame, Alan Serrels, Marc Vendrell
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-29691-w

Fluorescent amino acids as versatile building blocks for chemical biology

Author(s): Zhiming Cheng, Erkin Kuru, Amit Sachdeva, Marc Vendrell
Published in: Nature Reviews Chemistry, 4/6, 2020, Page(s) 275-290, ISSN 2397-3358
Publisher: Springer Nature
DOI: 10.1038/s41570-020-0186-z

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Author(s): Fabio de Moliner, Ina Biazruchka, Karolina Konsewicz, Sam Benson, Suraj Singh, Jun-Seok Lee, Marc Vendrell
Published in: Frontiers of Chemical Science and Engineering, 2021, ISSN 2095-0179
Publisher: Higher Education Press
DOI: 10.1007/s11705-021-2080-8

Near-Infrared Fluorescent Probes for the Detection of Cancer-Associated Proteases

Author(s): Jamie I. Scott, Qinyi Deng, Marc Vendrell
Published in: ACS Chemical Biology, 16/8, 2021, Page(s) 1304-1317, ISSN 1554-8929
Publisher: American Chemical Society
DOI: 10.1021/acschembio.1c00223

Fluorescent cyclic peptides for cell imaging

Author(s): Lorena Mendive‐Tapia, Jinling Wang, Marc Vendrell
Published in: Peptide Science, e24181, 2020, Page(s) e24181, ISSN 2475-8817
Publisher: Wiley
DOI: 10.1002/pep2.24181

Photoactivatable metabolic warheads enable precise and safe ablation of target cells in vivo

Author(s): Sam Benson, Fabio de Moliner, Antonio Fernandez, Erkin Kuru, Nicholas L. Asiimwe, Jun-Seok Lee, Lloyd Hamilton, Dirk Sieger, Isabel R. Bravo, Abigail M. Elliot, Yi Feng, Marc Vendrell
Published in: Nature Communications, 12/1, 2021, Page(s) 2369, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-22578-2

Effective Penetration of a Liposomal Formulation of Bleomycin through Ex-Vivo Skin Explants from Two Different Species

Author(s): Giulia Ferrari, Lisa Pang, Fabio De Moliner, Marc Vendrell, Richard Reardon, Andrew J. Higgins, Sunil Chopra, David Argyle
Published in: Cancers, 2022, ISSN 2072-6694
Publisher: Multidisciplinary Digital Publishing Institute (MDPI)
DOI: 10.3390/cancers14041083

Fluorogenic Trp(redBODIPY) cyclopeptide targeting keratin 1 for imaging of aggressive carcinomas

Author(s): Ramon Subiros-Funosas, Vivian Cheuk Lam Ho, Nicole D. Barth, Lorena Mendive-Tapia, Morena Pappalardo, Xavier Barril, Ruoyu Ma, Cheng-Bin Zhang, Bin-Zhi Qian, Miquel Sintes, Ouldouz Ghashghaei, Rodolfo Lavilla, Marc Vendrell
Published in: Chemical Science, 11/5, 2020, Page(s) 1368-1374, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c9sc05558d

A Functional Chemiluminescent Probe for in Vivo Imaging of Natural Killer Cell Activity Against Tumours

Author(s): Jamie I. Scott, Sara Gutkin, Ori Green, Emily J. Thompson, Takanori Kitamura, Doron Shabat, Marc Vendrell
Published in: Angewandte Chemie International Edition, 60/11, 2021, Page(s) 5699-5703, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202011429

Fluorescent peptides for imaging of fungal cells

Author(s): Can Zhao, Lorena Mendive-Tapia, Marc Vendrell
Published in: Archives of Biochemistry and Biophysics, 661, 2019, Page(s) 187-195, ISSN 0003-9861
Publisher: Academic Press
DOI: 10.1016/j.abb.2018.11.018

SCOTfluors: Small, Conjugatable, Orthogonal, and Tunable Fluorophores for In Vivo Imaging of Cell Metabolism

Author(s): Sam Benson, Antonio Fernandez, Nicole D. Barth, Fabio de Moliner, Mathew H. Horrocks, C. Simon Herrington, Jose Luis Abad, Antonio Delgado, Lisa Kelly, Ziyuan Chang, Yi Feng, Miyako Nishiura, Yuichiro Hori, Kazuya Kikuchi, Marc Vendrell
Published in: Angewandte Chemie International Edition, 58/21, 2019, Page(s) 6911-6915, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201900465

BODIPY‐Labeled Cyclobutanes by Secondary C(sp 3 )−H Arylations for Live‐Cell Imaging

Author(s): Matteo Virelli, Wei Wang, Rositha Kuniyil, Jun Wu, Giuseppe Zanoni, Antonio Fernandez, Jamie Scott, Marc Vendrell, Lutz Ackermann
Published in: Chemistry – A European Journal, 25/55, 2019, Page(s) 12712-12718, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.201903461

A Fluorescent Activatable AND-Gate Chemokine CCL2 Enables In Vivo Detection of Metastasis-Associated Macrophages

Author(s): Antonio Fernandez, Emily J. Thompson, Jeffrey W. Pollard, Takanori Kitamura, Marc Vendrell
Published in: Angewandte Chemie International Edition, 58/47, 2019, Page(s) 16894-16898, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.201910955

Natural product-inspired profluorophores for imaging NQO1 activity in tumour tissues

Author(s): Zhiming Cheng, Wagner O. Valença, Gleiston G. Dias, Jamie Scott, Nicole D. Barth, Fabio de Moliner, Gabriela B.P. Souza, Richard J. Mellanby, Marc Vendrell, Eufrânio N. da Silva Júnior
Published in: Bioorganic & Medicinal Chemistry, 27/17, 2019, Page(s) 3938-3946, ISSN 0968-0896
Publisher: Pergamon Press Ltd.
DOI: 10.1016/j.bmc.2019.07.017

In Vivo Tumor Visualization through MRI Off‐On Switching of NaGdF 4 –CaCO 3 Nanoconjugates

Author(s): Zhigao Yi, Zichao Luo, Nicole D. Barth, Xianfu Meng, Hong Liu, Wenbo Bu, Angelo All, Marc Vendrell, Xiaogang Liu
Published in: Advanced Materials, 31/37, 2019, Page(s) 1901851, ISSN 0935-9648
Publisher: United Nations Industrial Developement Organization
DOI: 10.1002/adma.201901851

Quinone-Derived π-Extended Phenazines as New Fluorogenic Probes for Live-Cell Imaging of Lipid Droplets

Author(s): Fabio de Moliner, Aaron King, Gleiston G. Dias, Guilherme F. de Lima, Carlos A. de Simone, Eufrânio N. da Silva Júnior, Marc Vendrell
Published in: Frontiers in Chemistry, 6, 2018, ISSN 2296-2646
Publisher: Frontiers
DOI: 10.3389/fchem.2018.00339

Tricarbocyanine N -triazoles: the scaffold-of-choice for long-term near-infrared imaging of immune cells in vivo

Author(s): Richard J. Mellanby, Jamie I. Scott, Iris Mair, Antonio Fernandez, Louise Saul, Jochen Arlt, Monica Moral, Marc Vendrell
Published in: Chemical Science, 9/36, 2018, Page(s) 7261-7270, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/c8sc00900g

3D bioprinting of mature bacterial biofilms for antimicrobial resistance drug testing

Author(s): Evita Ning, Gareth Turnbull, Jon Clarke, Fred Picard, Philip Riches, Marc Vendrell, Duncan Graham, Alastair W Wark, Karen Faulds, Wenmiao Shu
Published in: Biofabrication, 11/4, 2019, Page(s) 045018, ISSN 1758-5090
Publisher: IOP Publishing
DOI: 10.1088/1758-5090/ab37a0

A Bivalent Activatable Fluorescent Probe for Screening and Intravital Imaging of Chemotherapy-induced Cancer Cell Death

Author(s): Nicole D. Barth; Lorena Mendive-Tapia; Ramon Subiros-Funosas; Ouldouz Ghashghaie; Rodolfo Lavilla; Laura Maiorino; Xue-Yan He; Ian Dransfield; Mikala Egeblad; Marc Vendrell
Published in: Angewandte Chemie International Edition, 2021, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202113020

Activatable fluorophores for imaging immune cell function

Author(s): Lorena Mendive-Tapia, Marc Vendrell
Published in: Accounts of Chemical Research, 2022, ISSN 0001-4842
Publisher: American Chemical Society
DOI: 10.1021/acs.accounts.2c00070

Chemodivergent manganese-catalyzed C–H activation: modular synthesis of fluorogenic probes

Author(s): Nikolaos Kaplaneris, Jongwoo Son, Lorena Mendive-Tapia, Adelina Kopp, Nicole D. Barth, Isaac Maksso, Marc Vendrell, Lutz Ackermann
Published in: Nature Communications, 12/1, 2021, Page(s) 3389, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-021-23462-9

Rational Design and Synthesis of Large Stokes Shift 2,6-Sulphur-Disubstituted BODIPYs for Cell Imaging

Author(s): Abigail E Reese, Charles Lochenie, Ailsa Geddis, Luana A Machado, Marcos C de Souza, Flavia F C Marques, Carlos A de Simone, Marcos M Gouvea, Leandro F Pedrosa, Eufranio N da Silva Junior*, Marc Vendrell*
Published in: Chemosensors, 2022, ISSN 2227-9040
Publisher: MDPI
DOI: 10.3390/chemosensors10010019

A fluorogenic cyclic peptide for imaging and quantification of drug-induced apoptosis

Author(s): Nicole D. Barth, Ramon Subiros-Funosas, Lorena Mendive-Tapia, Rodger Duffin, Mario A. Shields, Jennifer A. Cartwright, Sónia Troeira Henriques, Jesus Sot, Felix M. Goñi, Rodolfo Lavilla, John A. Marwick, Sonja Vermeren, Adriano G. Rossi, Mikala Egeblad, Ian Dransfield, Marc Vendrell
Published in: Nature Communications, 11/1, 2020, Page(s) 4027-4040, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-020-17772-7

Rational Design of Phe‐BODIPY Amino Acids as Fluorogenic Building Blocks for Peptide‐based Detection of Urinary Tract Candida Infections

Author(s): Lorena Mendive-tapia, David Mendive-tapia, Can Zhao, Doireann Gordon, Sam Benson, Michael J. Bromley, Wei Wang, Jun Wu, Adelina Kopp, Lutz Ackermann, Marc Vendrell
Published in: Angewandte Chemie International Edition, 2022, ISSN 1521-3773
Publisher: Wiley
DOI: 10.1002/anie.202117218

Assessment of Neutrophil Apoptosis

Author(s): Nicole D. Barth, Marc Vendrell, David A. Dorward, Adriano G. Rossi, Ian Dransfield
Published in: Neutrophil - Methods and Protocols, 2087, 2020, Page(s) 167-190, ISBN 978-1-0716-0153-2
Publisher: Springer US
DOI: 10.1007/978-1-0716-0154-9_13

Near-infrared chromophores, process of preparation and methods of use

Author(s): Marc Vendrell, Antonio Fernandez, Richard Mellanby, Jamie Scott, Iris Mair, Claudia Garcia-Guzman, Baljean Dhillon, Pierre Bagnaninchi
Published in: 2019
Publisher: European Patent Office