Publications Peer reviewed articles (34) Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response Author(s): Sophia Y. Lunt, Sarah-Maria Fendt Published in: Current Opinion in Systems Biology, Issue 8, 2018, Page(s) 67-72, ISSN 2452-3100 Publisher: Elsevier DOI: 10.1016/j.coisb.2017.12.006 Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy Author(s): Sarah-Maria Fendt, Christian Frezza, Ayelet Erez Published in: Cancer Discovery, Issue 10/12, 2020, Page(s) 1797-1807, ISSN 2159-8274 Publisher: American Association for Cancer Research Inc. DOI: 10.1158/2159-8290.cd-20-0844 Lipid metabolism in cancer: New perspectives and emerging mechanisms Author(s): Lindsay A. Broadfield, Antonino Alejandro Pane, Ali Talebi, Johannes V. Swinnen, and Sarah-Maria Fendt Published in: Developmental Cell, Issue 15345807, 2021, ISSN 1534-5807 Publisher: Cell Press DOI: 10.1016/j.devcel.2021.04.013 Age-induced accumulation of methylmalonic acid promotes tumour progression Author(s): Ana P. Gomes, Didem Ilter, Vivien Low, Jennifer E. Endress, Juan Fernández-García, Adam Rosenzweig, Tanya Schild, Dorien Broekaert, Adnan Ahmed, Melanie Planque, Ilaria Elia, Julie Han, Charles Kinzig, Edouard Mullarky, Anders P. Mutvei, John Asara, Rafael de Cabo, Lewis C. Cantley, Noah Dephoure, Sarah-Maria Fendt, John Blenis Published in: Nature, Issue 585/7824, 2020, Page(s) 283-287, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-020-2630-0 Macrophages are metabolically heterogeneous within the tumor microenvironment Author(s): Xenia Geeraerts, Juan Fernández-Garcia, Felix J.Hartmann, Kyra E.de Goede, Liesbet Martens, Yvon Elkrim, Ayla Debraekeleer, Benoit Stijlemans, Anke Vandekeere, Gianmarco Rinaldi, Riet De Rycke, Mélanie Planque, Dorien Broekaert, Elisa Meinster, Emile Clappaert, Pauline Bardet, Aleksandar Murgaski, Conny Gysemans, Frank Aboubakar Nana, Yvan Saeys, Sean C. Bendall, Damya Laoui, Jan Van den Bossche Published in: Cell Reports, Issue 22111247, 2021, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2021.110171 Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis Author(s): Madeleine Dorsch, Manuela Kowalczyk, Mélanie Planque, Geronimo Heilmann, Sebastian Urban, Philip Dujardin, Jan Forster, Kristina Ueffing, Silke Nothdurft, Sebastian Oeck, Annika Paul, Sven T. Liffers, Farnusch Kaschani, Markus Kaiser, Alexander Schramm, Jens T. Siveke, Monte M. Winslow, Sarah-Maria Fendt, Perihan Nalbant, Barbara M. Grüner Published in: Cell Reports, Issue 22111247, 2021, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2021.110056 Molecular differences of angiogenic versus vessel co-opting colorectal cancer liver metastases at single-cell resolution Author(s): Johannes Robert Fleischer, Alexandra Maria Schmitt, Gwendolyn Haas, Xingbo Xu, Elisabeth Maria Zeisberg, Hanibal Bohnenberger, Stefan Küffer, Laure-Anne Teuwen, Philipp Johannes Karras, Tim Beißbarth, Annalen Bleckmann, Mélanie Planque, Sarah-Maria Fendt, Peter Vermeulen, Michael Ghadimi, Joanna Kalucka, Tiago De Oliveira & Lena-Christin Conradi Published in: Molecular Cancer, Issue 22, 2023, ISSN 1476-4598 Publisher: BioMed Central DOI: 10.1186/s12943-023-01713-1 The metabolism of cancer cells during metastasis Author(s): Gabriele Bergers, Sarah-Maria Fendt Published in: Nature Reviews Cancer, Issue 21/3, 2021, Page(s) 162-180, ISSN 1474-175X Publisher: Nature Publishing Group DOI: 10.1038/s41568-020-00320-2 Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo Author(s): Juan Fernández-García, Patricia Altea-Manzano, Erica Pranzini, Sarah-Maria Fendt Published in: Trends in Biochemical Sciences, Issue 45/3, 2020, Page(s) 185-201, ISSN 0968-0004 Publisher: Elsevier BV DOI: 10.1016/j.tibs.2019.12.002 CD40 signal rewires fatty acid and glutamine metabolism for stimulating macrophage anti-tumorigenic functions Author(s): Pu-Ste Liu, Yi-Ting Chen, Xiaoyun Li, Pei-Chun Hsueh, Sheue-Fen Tzeng, Hsi Chen, Pei-Zhu Shi, Xin Xie, Sweta Parik, Mélanie Planque, Sarah-Maria Fendt & Ping-Chih Ho Published in: Nature Immunology, Issue 24, 2023, Page(s) 452-462, ISSN 1548-7091 Publisher: Nature Publishing Group DOI: 10.1038/s41590-023-01430-3 In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition Author(s): Gianmarco Rinaldi, Erica Pranzini, Joke Van Elsen, Dorien Broekaert, Cornelius M. Funk, Mélanie Planque, Ginevra Doglioni, Patricia Altea-Manzano, Matteo Rossi, Vincent Geldhof, Shao Thing Teoh, Christina Ross, Kent W. Hunter, Sophia Y. Lunt, Thomas G.P. Grünewald, Sarah-Maria Fendt Published in: Molecular Cell, 2020, ISSN 1097-2765 Publisher: Cell Press DOI: 10.1016/j.molcel.2020.11.027 Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take Author(s): Patricia Altea‐Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah‐Maria Fendt Published in: EMBO reports, Issue 21/10, 2020, ISSN 1469-221X Publisher: Nature Publishing Group DOI: 10.15252/embr.202050635 Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization Author(s): Jing Zhang, Jonathan Muri, Gillian Fitzgerald, Tatiane Gorski, Roberto Gianni-Barrera, Evi Masschelein, Gommaar D’Hulst, Paola Gilardoni, Guillermo Turiel, Zheng Fan, TongTong Wang, Mélanie Planque, Peter Carmeliet, Luc Pellerin, Christian Wolfrum, Sarah-Maria Fendt, Andrea Banfi, Christian Stockmann, Inés Soro-Arnáiz, Manfred Kopf, Katrien De Bock Published in: Cell Metabolism, Issue 31/6, 2020, Page(s) 1136-1153.e7, ISSN 1550-4131 Publisher: Cell Press DOI: 10.1016/j.cmet.2020.05.004 PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells Author(s): Gabriele Bluemel, Mélanie Planque, Corina T. Madreiter-Sokolowski, Theresa Haitzmann, Andelko Hrzenjak, Wolfgang F. Graier, Sarah-Maria Fendt, Horst Olschewski, Katharina Leithner Published in: FREE RADICAL BIOLOGY AND MEDICINE, Issue 08915849, 2021, ISSN 0891-5849 Publisher: Elsevier BV DOI: 10.1016/j.freeradbiomed.2021.09.007 Mitochondria metabolism sets the species-specific tempo of neuronal development Author(s): Iwata R, Casimir P, Erkol E, Boubakar L, Gallego López IM, Planque M, Ditkowska M, Gaspariunaite V, Beckers S, Remans D, Vints K, Vandekeere A, Poovathingal S, Bird M, Corthout N, Vermeersch P, Carpentier S, Davie K, Mazzone M, Gounko NV, Aerts S, Ghesquiere B, Fendt S-M, Vanderhaeghen P Published in: Science, Issue 379/6632, 2023, ISSN 0036-8075 Publisher: American Association for the Advancement of Science DOI: 10.1126/science.abn4705 Altered propionate metabolism contributes to tumour progression and aggressiveness Author(s): Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer, Anders P. Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt, John Blenis Published in: Nature Metabolism, Issue 25225812, 2022, ISSN 2522-5812 Publisher: Nature Research DOI: 10.1038/s42255-022-00553-5 In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1 Author(s): Emily M. Christensen, Alexandra N. Bogner, Anke Vandekeere, Gabriela S. Tam, Sagar M. Patel, Donald F. Becker, Sarah-Maria Fendt, John J. Tanner Published in: Journal of Biological Chemistry, Issue 295/52, 2020, Page(s) 18316-18327, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.ra120.016106 Nuclear PHGDH protects cancer cells from nutrient stress Author(s): Daniela Annibali, Sarah-Maria Fendt Published in: NATURE METABOLISM, Issue 25225812, 2021, ISSN 2522-5812 Publisher: NATURE PORTFOLIO DOI: 10.1038/s42255-021-00448-x mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis Author(s): Mouna Triki, Gianmarco Rinaldi, Melanie Planque, Dorien Broekaert, Alina M. Winkelkotte, Carina R. Maier, Sudha Janaki Raman, Anke Vandekeere, Joke Van Elsen, Martin F. Orth, Thomas G.P. Grünewald, Almut Schulze, Sarah-Maria Fendt Published in: Cell Reports, Issue 31/12, 2020, Page(s) 107806, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2020.107806 Metabolite-derived protein modifications modulating oncogenic signaling Author(s): Yawen Liu, Anke Vandekeere, Min Xu, Sarah-Maria Fendt, Patricia Altea-Manzano Published in: Frontiers in Oncology, 2022, ISSN 2234-943X Publisher: Frontiers Media S. A. DOI: 10.3389/fonc.2022.988626 Breast cancer cells rely on environmental pyruvate to shape the metastatic niche Author(s): Ilaria Elia, Matteo Rossi, Steve Stegen, Dorien Broekaert, Ginevra Doglioni, Marit van Gorsel, Ruben Boon, Carmen Escalona-Noguero, Sophie Torrekens, Catherine Verfaillie, Erik Verbeken, Geert Carmeliet, Sarah-Maria Fendt Published in: Nature, Issue 568/7750, 2019, Page(s) 117-121, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-019-0977-x Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity Author(s): Kim Vriens, Stefan Christen, Sweta Parik, Dorien Broekaert, Kazuaki Yoshinaga, Ali Talebi, Jonas Dehairs, Carmen Escalona-Noguero, Roberta Schmieder, Thomas Cornfield, Catriona Charlton, Laura Romero-Pérez, Matteo Rossi, Gianmarco Rinaldi, Martin F. Orth, Ruben Boon, Axelle Kerstens, Suet Ying Kwan, Brandon Faubert, Andrés Méndez-Lucas, Charlotte C. Kopitz, Ting Chen, Juan Fernandez-Garcia, Jo Published in: Nature, Issue 566/7744, 2019, Page(s) 403-406, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-019-0904-1 Metabolic Hallmarks of Metastasis Formation Author(s): Ilaria Elia, Ginevra Doglioni, Sarah-Maria Fendt Published in: Trends in Cell Biology, Issue 28/8, 2018, Page(s) 673-684, ISSN 0962-8924 Publisher: Elsevier BV DOI: 10.1016/j.tcb.2018.04.002 Interactions in the (Pre)metastatic Niche Support Metastasis Formation Author(s): Ginevra Doglioni, Sweta Parik, Sarah-Maria Fendt Published in: Frontiers in Oncology, Issue 9, 2019, ISSN 2234-943X Publisher: Frontiers Media S. A. DOI: 10.3389/fonc.2019.00219 Navigating metabolic pathways to enhance antitumour immunity and immunotherapy Author(s): Xiaoyun Li, Mathias Wenes, Pedro Romero, Stanley Ching-Cheng Huang, Sarah-Maria Fendt, Ping-Chih Ho Published in: Nature Reviews Clinical Oncology, Issue 16/7, 2019, Page(s) 425-441, ISSN 1759-4774 Publisher: Nature Publishing Group DOI: 10.1038/s41571-019-0203-7 CD8+ T cell metabolic rewiring defined by scRNA-seq identifies a critical role of ASNS expression dynamics in T cell differentiation Author(s): Juan Fernández-García, Fabien Franco, Sweta Parik, Patricia Altea-Manzano, Antonino Alejandro Pane, Dorien Broekaert, Joke van Elsen, Ines Vermeire, Tessa Schalley, Mélanie Planque, Thomas van Brussel, Rogier Schepers, Elodie Modave, Tobias K. Karakach, Peter Carmeliet, Diether Lambrechts, Ping-Chih Ho, Sarah-MariaFendt Published in: Cell Reports, Issue 41/7, 2022, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2022.111639 A palmitate-rich metastatic niche enables metastasis growth via p65 acetylation resulting in pro-metastatic NF-kB signaling Author(s): Altea-Manzano P, Doglioni G, Liu Y, Cuadros AM, Nolan E, Fernández-García J, Wu Q, Planque M, Laue KJ, Cidre-Aranaz F, Liu X, Marin-Bejar O, Van Elsen J, Vermeire I, Broekaert D, Demeyer S, Spotbeen X, Idkowiak J, Montagne A, Demicco M, Alkan HF, Rabas N, Riera-Domingo C, Richard F, Geukens T, De Schepper M, Leduc S, Hatse S, Lambrechts Y, Kay EJ, Lilla S, Alekseenko A, Geldhof V, Boeckx B, de l Published in: Nature Cancer, Issue 4, 2023, Page(s) 344-364, ISSN 2662-1347 Publisher: Nature Cancer DOI: 10.1038/s43018-023-00513-2 Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle Author(s): Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquière, Bernard Thienpont, Sarah-Maria Fendt, Nick van Gastel, Geert Carmeliet Published in: Cell reports, Issue 22111247, 2022, ISSN 2211-1247 Publisher: Cell Press DOI: 10.1016/j.celrep.2022.111105 Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis Author(s): Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G.P. Grünewald, Adrian Liston, Published in: Cancer Research, Issue 81/8, 2021, Page(s) 1988-2001, ISSN 0008-5472 Publisher: American Association for Cancer Research DOI: 10.1158/0008-5472.can-20-1954 PHGDH heterogeneity potentiates cancer cell dissemination and metastasis Author(s): Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros AM, Fernandez-Garcia J, Riera-Domingo C, Jauset C, Planque M, Alkan HF, Nittner D, Zuo D, Broadfield LA, Parik S, Pane AA, Rizzollo F, Rinaldi G, Zhang T, Teoh ST, Aurora AB, Karras P, Vermeire I, Broekaert D, Van Elsen J, Knott MML, Orth MF, Demeyer S, Eelen G, Dobrolecki LE, Bassez A, Van Brussel T, Sotlar Published in: Nature, Issue 00280836, 2022, ISSN 0028-0836 Publisher: Nature Publishing Group DOI: 10.1038/s41586-022-04758-2 Pharmacological induction of membrane lipid poly-unsaturation sensitizes melanoma to ROS inducers and overcomes acquired resistance to targeted therapy Author(s): Ali Talebi, Vincent de Laat, Xander Spotbeen, Jonas Dehairs, Florian Rambow, Aljosja Rogiers, Frank Vanderhoydonc, Lara Rizotto, Mélanie Planque, Ginevra Doglioni, Sahar Motamedi, David Nittner, Tania Roskams, Patrizia Agostinis, Oliver Bechter, Veerle Boecxstaens, Marjan Garmyn, Marie O’Farrell, Alan Wagman, George Kemble, Eleonora Leucci, Sarah-Maria Fendt, Jean-Christophe Marine & Johannes V Published in: Journal of experimental and clinical cancer research, Issue 42, 2023, ISSN 0392-9078 Publisher: BioMed Central DOI: 10.1186/s13046-023-02664-7 Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers Author(s): Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes V. Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt, Published in: Nature Communications, Issue 20411723, 2022, ISSN 2041-1723 Publisher: Nature Publishing Group DOI: 10.1038/s41467-022-32272-6 In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1 Author(s): Emily M. Christensen, Alexandra N. Bogner, Anke Vandekeere, Gabriela S. Tam, Sagar M. Patel, Donald F. Becker, Sarah-Maria Fendt, John J. Tanner Published in: Journal of Biological Chemistry, 2020, Page(s) jbc.RA120.016106, ISSN 0021-9258 Publisher: American Society for Biochemistry and Molecular Biology Inc. DOI: 10.1074/jbc.ra120.016106 GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomidefmetas Author(s): Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter and Sarah-Maria Fendt Published in: Frontiers in oncology, Issue 2234943X, 2022, ISSN 2234-943X Publisher: Frontiers Media S. A. DOI: 10.3389/fonc.2022.988872 Other (1) In vivo CRISPR screen defines Slc25a37 as an organ-specific regulator of antioxidant metabolism in metastasis Author(s): Alejandro M. Cuadros, Juan Fernández-Garcia, Mélanie Planque, Patricia Altea-Manzano, Tessa Schalley, Ines Vermeire, Dorien Broekaert, Qi Wu, Thomas Van Brussel, Sophia Leduc, Marion Maetens, Ha-Linh Nguyen, Karen Van Baelen, Naama Darzi, Giuseppe Floris, Hans Wildiers, Christine Desmedt, Diether Lambrechts, Sarah-Maria Fendt Published in: BioRxiv, 2022 Publisher: BioRxiv DOI: 10.1101/2022.09.03.506468 Non-peer reviewed articles (2) Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects Author(s): Sarah-Maria Fendt, Sophia Y. Lunt Published in: Cancer Cell, Issue 37/2, 2020, Page(s) 141-142, ISSN 1535-6108 Publisher: Cell Press DOI: 10.1016/j.ccell.2020.01.009 Metabolic vulnerabilities of metastasizing cancer cells Author(s): Sarah-Maria Fendt Published in: BMC Biology, Issue 17/1, 2019, ISSN 1741-7007 Publisher: BioMed Central DOI: 10.1186/s12915-019-0672-2 Book chapters (3) Assessing the Impact of the Nutrient Microenvironment on the Metabolism of Effector CD8+ T Cells Author(s): Juan Fernández-García, Sarah-Maria Fendt Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 187-216, ISBN 978-1-4939-8768-9 Publisher: Springer New York DOI: 10.1007/978-1-4939-8769-6_14 Measuring In Vivo Tissue Metabolism Using 13C Glucose Infusions in Mice Author(s): Dorien Broekaert, Sarah-Maria Fendt Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 67-82, ISBN 978-1-4939-8768-9 Publisher: Springer New York DOI: 10.1007/978-1-4939-8769-6_5 13C Tracer Analysis and Metabolomics in 3D Cultured Cancer Cells Author(s): Marit van Gorsel, Ilaria Elia, Sarah-Maria Fendt Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 53-66, ISBN 978-1-4939-8768-9 Publisher: Springer New York DOI: 10.1007/978-1-4939-8769-6_4 Searching for OpenAIRE data... 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