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Metabolic regulation of metastatic growth

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Publications

Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response

Author(s): Sophia Y. Lunt, Sarah-Maria Fendt
Published in: Current Opinion in Systems Biology, Issue 8, 2018, Page(s) 67-72, ISSN 2452-3100
DOI: 10.1016/j.coisb.2017.12.006

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

Author(s): Sarah-Maria Fendt, Christian Frezza, Ayelet Erez
Published in: Cancer Discovery, Issue 10/12, 2020, Page(s) 1797-1807, ISSN 2159-8274
DOI: 10.1158/2159-8290.cd-20-0844

Age-induced accumulation of methylmalonic acid promotes tumour progression

Author(s): Ana P. Gomes, Didem Ilter, Vivien Low, Jennifer E. Endress, Juan Fernández-García, Adam Rosenzweig, Tanya Schild, Dorien Broekaert, Adnan Ahmed, Melanie Planque, Ilaria Elia, Julie Han, Charles Kinzig, Edouard Mullarky, Anders P. Mutvei, John Asara, Rafael de Cabo, Lewis C. Cantley, Noah Dephoure, Sarah-Maria Fendt, John Blenis
Published in: Nature, Issue 585/7824, 2020, Page(s) 283-287, ISSN 0028-0836
DOI: 10.1038/s41586-020-2630-0

The metabolism of cancer cells during metastasis

Author(s): Gabriele Bergers, Sarah-Maria Fendt
Published in: Nature Reviews Cancer, Issue 21/3, 2021, Page(s) 162-180, ISSN 1474-175X
DOI: 10.1038/s41568-020-00320-2

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo

Author(s): Juan Fernández-García, Patricia Altea-Manzano, Erica Pranzini, Sarah-Maria Fendt
Published in: Trends in Biochemical Sciences, Issue 45/3, 2020, Page(s) 185-201, ISSN 0968-0004
DOI: 10.1016/j.tibs.2019.12.002

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

Author(s): Gianmarco Rinaldi, Erica Pranzini, Joke Van Elsen, Dorien Broekaert, Cornelius M. Funk, Mélanie Planque, Ginevra Doglioni, Patricia Altea-Manzano, Matteo Rossi, Vincent Geldhof, Shao Thing Teoh, Christina Ross, Kent W. Hunter, Sophia Y. Lunt, Thomas G.P. Grünewald, Sarah-Maria Fendt
Published in: Molecular Cell, 2020, ISSN 1097-2765
DOI: 10.1016/j.molcel.2020.11.027

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take

Author(s): Patricia Altea‐Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah‐Maria Fendt
Published in: EMBO reports, Issue 21/10, 2020, ISSN 1469-221X
DOI: 10.15252/embr.202050635

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Author(s): Jing Zhang, Jonathan Muri, Gillian Fitzgerald, Tatiane Gorski, Roberto Gianni-Barrera, Evi Masschelein, Gommaar D’Hulst, Paola Gilardoni, Guillermo Turiel, Zheng Fan, TongTong Wang, Mélanie Planque, Peter Carmeliet, Luc Pellerin, Christian Wolfrum, Sarah-Maria Fendt, Andrea Banfi, Christian Stockmann, Inés Soro-Arnáiz, Manfred Kopf, Katrien De Bock
Published in: Cell Metabolism, Issue 31/6, 2020, Page(s) 1136-1153.e7, ISSN 1550-4131
DOI: 10.1016/j.cmet.2020.05.004

In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1

Author(s): Emily M. Christensen, Alexandra N. Bogner, Anke Vandekeere, Gabriela S. Tam, Sagar M. Patel, Donald F. Becker, Sarah-Maria Fendt, John J. Tanner
Published in: Journal of Biological Chemistry, Issue 295/52, 2020, Page(s) 18316-18327, ISSN 0021-9258
DOI: 10.1074/jbc.ra120.016106

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis

Author(s): Mouna Triki, Gianmarco Rinaldi, Melanie Planque, Dorien Broekaert, Alina M. Winkelkotte, Carina R. Maier, Sudha Janaki Raman, Anke Vandekeere, Joke Van Elsen, Martin F. Orth, Thomas G.P. Grünewald, Almut Schulze, Sarah-Maria Fendt
Published in: Cell Reports, Issue 31/12, 2020, Page(s) 107806, ISSN 2211-1247
DOI: 10.1016/j.celrep.2020.107806

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

Author(s): Ilaria Elia, Matteo Rossi, Steve Stegen, Dorien Broekaert, Ginevra Doglioni, Marit van Gorsel, Ruben Boon, Carmen Escalona-Noguero, Sophie Torrekens, Catherine Verfaillie, Erik Verbeken, Geert Carmeliet, Sarah-Maria Fendt
Published in: Nature, Issue 568/7750, 2019, Page(s) 117-121, ISSN 0028-0836
DOI: 10.1038/s41586-019-0977-x

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Author(s): Kim Vriens, Stefan Christen, Sweta Parik, Dorien Broekaert, Kazuaki Yoshinaga, Ali Talebi, Jonas Dehairs, Carmen Escalona-Noguero, Roberta Schmieder, Thomas Cornfield, Catriona Charlton, Laura Romero-Pérez, Matteo Rossi, Gianmarco Rinaldi, Martin F. Orth, Ruben Boon, Axelle Kerstens, Suet Ying Kwan, Brandon Faubert, Andrés Méndez-Lucas, Charlotte C. Kopitz, Ting Chen, Juan Fernandez-Garcia, Jo
Published in: Nature, Issue 566/7744, 2019, Page(s) 403-406, ISSN 0028-0836
DOI: 10.1038/s41586-019-0904-1

Metabolic Hallmarks of Metastasis Formation

Author(s): Ilaria Elia, Ginevra Doglioni, Sarah-Maria Fendt
Published in: Trends in Cell Biology, Issue 28/8, 2018, Page(s) 673-684, ISSN 0962-8924
DOI: 10.1016/j.tcb.2018.04.002

Interactions in the (Pre)metastatic Niche Support Metastasis Formation

Author(s): Ginevra Doglioni, Sweta Parik, Sarah-Maria Fendt
Published in: Frontiers in Oncology, Issue 9, 2019, ISSN 2234-943X
DOI: 10.3389/fonc.2019.00219

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

Author(s): Xiaoyun Li, Mathias Wenes, Pedro Romero, Stanley Ching-Cheng Huang, Sarah-Maria Fendt, Ping-Chih Ho
Published in: Nature Reviews Clinical Oncology, Issue 16/7, 2019, Page(s) 425-441, ISSN 1759-4774
DOI: 10.1038/s41571-019-0203-7

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Author(s): Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G.P. Grünewald, Adrian Liston,
Published in: Cancer Research, Issue 81/8, 2021, Page(s) 1988-2001, ISSN 0008-5472
DOI: 10.1158/0008-5472.can-20-1954

In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1

Author(s): Emily M. Christensen, Alexandra N. Bogner, Anke Vandekeere, Gabriela S. Tam, Sagar M. Patel, Donald F. Becker, Sarah-Maria Fendt, John J. Tanner
Published in: Journal of Biological Chemistry, 2020, Page(s) jbc.RA120.016106, ISSN 0021-9258
DOI: 10.1074/jbc.ra120.016106

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects

Author(s): Sarah-Maria Fendt, Sophia Y. Lunt
Published in: Cancer Cell, Issue 37/2, 2020, Page(s) 141-142, ISSN 1535-6108
DOI: 10.1016/j.ccell.2020.01.009

Metabolic vulnerabilities of metastasizing cancer cells

Author(s): Sarah-Maria Fendt
Published in: BMC Biology, Issue 17/1, 2019, ISSN 1741-7007
DOI: 10.1186/s12915-019-0672-2

Assessing the Impact of the Nutrient Microenvironment on the Metabolism of Effector CD8+ T Cells

Author(s): Juan Fernández-García, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 187-216
DOI: 10.1007/978-1-4939-8769-6_14

Measuring In Vivo Tissue Metabolism Using 13C Glucose Infusions in Mice

Author(s): Dorien Broekaert, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 67-82
DOI: 10.1007/978-1-4939-8769-6_5

13C Tracer Analysis and Metabolomics in 3D Cultured Cancer Cells

Author(s): Marit van Gorsel, Ilaria Elia, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, Issue 1862, 2019, Page(s) 53-66
DOI: 10.1007/978-1-4939-8769-6_4