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Metabolic regulation of metastatic growth

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Publications

Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response

Author(s): Sophia Y. Lunt, Sarah-Maria Fendt
Published in: Current Opinion in Systems Biology, 8, 2018, Page(s) 67-72, ISSN 2452-3100
Publisher: Elsevier
DOI: 10.1016/j.coisb.2017.12.006

Targeting Metabolic Plasticity and Flexibility Dynamics for Cancer Therapy

Author(s): Sarah-Maria Fendt, Christian Frezza, Ayelet Erez
Published in: Cancer Discovery, 10/12, 2020, Page(s) 1797-1807, ISSN 2159-8274
Publisher: American Association for Cancer Research Inc.
DOI: 10.1158/2159-8290.cd-20-0844

Lipid metabolism in cancer: New perspectives and emerging mechanisms

Author(s): Lindsay A. Broadfield, Antonino Alejandro Pane, Ali Talebi, Johannes V. Swinnen, and Sarah-Maria Fendt
Published in: Developmental Cell, 15345807, 2021, ISSN 1534-5807
Publisher: Cell Press
DOI: 10.1016/j.devcel.2021.04.013

Age-induced accumulation of methylmalonic acid promotes tumour progression

Author(s): Ana P. Gomes, Didem Ilter, Vivien Low, Jennifer E. Endress, Juan Fernández-García, Adam Rosenzweig, Tanya Schild, Dorien Broekaert, Adnan Ahmed, Melanie Planque, Ilaria Elia, Julie Han, Charles Kinzig, Edouard Mullarky, Anders P. Mutvei, John Asara, Rafael de Cabo, Lewis C. Cantley, Noah Dephoure, Sarah-Maria Fendt, John Blenis
Published in: Nature, 585/7824, 2020, Page(s) 283-287, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2630-0

Macrophages are metabolically heterogeneous within the tumor microenvironment

Author(s): Xenia Geeraerts, Juan Fernández-Garcia, Felix J.Hartmann, Kyra E.de Goede, Liesbet Martens, Yvon Elkrim, Ayla Debraekeleer, Benoit Stijlemans, Anke Vandekeere, Gianmarco Rinaldi, Riet De Rycke, Mélanie Planque, Dorien Broekaert, Elisa Meinster, Emile Clappaert, Pauline Bardet, Aleksandar Murgaski, Conny Gysemans, Frank Aboubakar Nana, Yvan Saeys, Sean C. Bendall, Damya Laoui, Jan Van den Bossche
Published in: Cell Reports, 22111247, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110171

Statins affect cancer cell plasticity with distinct consequences for tumor progression and metastasis

Author(s): Madeleine Dorsch, Manuela Kowalczyk, Mélanie Planque, Geronimo Heilmann, Sebastian Urban, Philip Dujardin, Jan Forster, Kristina Ueffing, Silke Nothdurft, Sebastian Oeck, Annika Paul, Sven T. Liffers, Farnusch Kaschani, Markus Kaiser, Alexander Schramm, Jens T. Siveke, Monte M. Winslow, Sarah-Maria Fendt, Perihan Nalbant, Barbara M. Grüner
Published in: Cell Reports, 22111247, 2021, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2021.110056

The metabolism of cancer cells during metastasis

Author(s): Gabriele Bergers, Sarah-Maria Fendt
Published in: Nature Reviews Cancer, 21/3, 2021, Page(s) 162-180, ISSN 1474-175X
Publisher: Nature Publishing Group
DOI: 10.1038/s41568-020-00320-2

Stable Isotopes for Tracing Mammalian-Cell Metabolism In Vivo

Author(s): Juan Fernández-García, Patricia Altea-Manzano, Erica Pranzini, Sarah-Maria Fendt
Published in: Trends in Biochemical Sciences, 45/3, 2020, Page(s) 185-201, ISSN 0968-0004
Publisher: Elsevier BV
DOI: 10.1016/j.tibs.2019.12.002

In Vivo Evidence for Serine Biosynthesis-Defined Sensitivity of Lung Metastasis, but Not of Primary Breast Tumors, to mTORC1 Inhibition

Author(s): Gianmarco Rinaldi, Erica Pranzini, Joke Van Elsen, Dorien Broekaert, Cornelius M. Funk, Mélanie Planque, Ginevra Doglioni, Patricia Altea-Manzano, Matteo Rossi, Vincent Geldhof, Shao Thing Teoh, Christina Ross, Kent W. Hunter, Sophia Y. Lunt, Thomas G.P. Grünewald, Sarah-Maria Fendt
Published in: Molecular Cell, 2020, ISSN 1097-2765
Publisher: Cell Press
DOI: 10.1016/j.molcel.2020.11.027

Nutrient metabolism and cancer in the in vivo context: a metabolic game of give and take

Author(s): Patricia Altea‐Manzano, Alejandro M Cuadros, Lindsay A Broadfield, Sarah‐Maria Fendt
Published in: EMBO reports, 21/10, 2020, ISSN 1469-221X
Publisher: Nature Publishing Group
DOI: 10.15252/embr.202050635

Endothelial Lactate Controls Muscle Regeneration from Ischemia by Inducing M2-like Macrophage Polarization

Author(s): Jing Zhang, Jonathan Muri, Gillian Fitzgerald, Tatiane Gorski, Roberto Gianni-Barrera, Evi Masschelein, Gommaar D’Hulst, Paola Gilardoni, Guillermo Turiel, Zheng Fan, TongTong Wang, Mélanie Planque, Peter Carmeliet, Luc Pellerin, Christian Wolfrum, Sarah-Maria Fendt, Andrea Banfi, Christian Stockmann, Inés Soro-Arnáiz, Manfred Kopf, Katrien De Bock
Published in: Cell Metabolism, 31/6, 2020, Page(s) 1136-1153.e7, ISSN 1550-4131
Publisher: Cell Press
DOI: 10.1016/j.cmet.2020.05.004

PCK2 opposes mitochondrial respiration and maintains the redox balance in starved lung cancer cells

Author(s): Gabriele Bluemel, Mélanie Planque, Corina T. Madreiter-Sokolowski, Theresa Haitzmann, Andelko Hrzenjak, Wolfgang F. Graier, Sarah-Maria Fendt, Horst Olschewski, Katharina Leithner
Published in: FREE RADICAL BIOLOGY AND MEDICINE, 08915849, 2021, ISSN 0891-5849
Publisher: Elsevier BV
DOI: 10.1016/j.freeradbiomed.2021.09.007

Altered propionate metabolism contributes to tumour progression and aggressiveness

Author(s): Ana P. Gomes, Didem Ilter, Vivien Low, Stanislav Drapela, Tanya Schild, Edouard Mullarky, Julie Han, Ilaria Elia, Dorien Broekaert, Adam Rosenzweig, Michal Nagiec, Joana B. Nunes, Bethany E. Schaffer, Anders P. Mutvei, John M. Asara, Lewis C. Cantley, Sarah-Maria Fendt, John Blenis
Published in: Nature Metabolism, 25225812, 2022, ISSN 2522-5812
Publisher: Nature Research
DOI: 10.1038/s42255-022-00553-5

In crystallo screening for proline analog inhibitors of the proline cycle enzyme PYCR1

Author(s): Emily M. Christensen, Alexandra N. Bogner, Anke Vandekeere, Gabriela S. Tam, Sagar M. Patel, Donald F. Becker, Sarah-Maria Fendt, John J. Tanner
Published in: Journal of Biological Chemistry, 295/52, 2020, Page(s) 18316-18327, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.016106

Nuclear PHGDH protects cancer cells from nutrient stress

Author(s): Daniela Annibali, Sarah-Maria Fendt
Published in: NATURE METABOLISM, 25225812, 2021, ISSN 2522-5812
Publisher: NATURE PORTFOLIO
DOI: 10.1038/s42255-021-00448-x

mTOR Signaling and SREBP Activity Increase FADS2 Expression and Can Activate Sapienate Biosynthesis

Author(s): Mouna Triki, Gianmarco Rinaldi, Melanie Planque, Dorien Broekaert, Alina M. Winkelkotte, Carina R. Maier, Sudha Janaki Raman, Anke Vandekeere, Joke Van Elsen, Martin F. Orth, Thomas G.P. Grünewald, Almut Schulze, Sarah-Maria Fendt
Published in: Cell Reports, 31/12, 2020, Page(s) 107806, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2020.107806

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

Author(s): Ilaria Elia, Matteo Rossi, Steve Stegen, Dorien Broekaert, Ginevra Doglioni, Marit van Gorsel, Ruben Boon, Carmen Escalona-Noguero, Sophie Torrekens, Catherine Verfaillie, Erik Verbeken, Geert Carmeliet, Sarah-Maria Fendt
Published in: Nature, 568/7750, 2019, Page(s) 117-121, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-0977-x

Evidence for an alternative fatty acid desaturation pathway increasing cancer plasticity

Author(s): Kim Vriens, Stefan Christen, Sweta Parik, Dorien Broekaert, Kazuaki Yoshinaga, Ali Talebi, Jonas Dehairs, Carmen Escalona-Noguero, Roberta Schmieder, Thomas Cornfield, Catriona Charlton, Laura Romero-Pérez, Matteo Rossi, Gianmarco Rinaldi, Martin F. Orth, Ruben Boon, Axelle Kerstens, Suet Ying Kwan, Brandon Faubert, Andrés Méndez-Lucas, Charlotte C. Kopitz, Ting Chen, Juan Fernandez-Garcia, Jo
Published in: Nature, 00280836, 2019, Page(s) 403-406, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-019-0904-1

Metabolic Hallmarks of Metastasis Formation

Author(s): Ilaria Elia, Ginevra Doglioni, Sarah-Maria Fendt
Published in: Trends in Cell Biology, 28/8, 2018, Page(s) 673-684, ISSN 0962-8924
Publisher: Elsevier BV
DOI: 10.1016/j.tcb.2018.04.002

Interactions in the (Pre)metastatic Niche Support Metastasis Formation

Author(s): Ginevra Doglioni, Sweta Parik, Sarah-Maria Fendt
Published in: Frontiers in Oncology, 9, 2019, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2019.00219

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

Author(s): Xiaoyun Li, Mathias Wenes, Pedro Romero, Stanley Ching-Cheng Huang, Sarah-Maria Fendt, Ping-Chih Ho
Published in: Nature Reviews Clinical Oncology, 16/7, 2019, Page(s) 425-441, ISSN 1759-4774
Publisher: Nature Publishing Group
DOI: 10.1038/s41571-019-0203-7

Skeletal progenitors preserve proliferation and self-renewal upon inhibition of mitochondrial respiration by rerouting the TCA cycle

Author(s): Guillaume Tournaire, Shauni Loopmans, Steve Stegen, Gianmarco Rinaldi, Guy Eelen, Sophie Torrekens, Karen Moermans, Peter Carmeliet, Bart Ghesquière, Bernard Thienpont, Sarah-Maria Fendt, Nick van Gastel, Geert Carmeliet
Published in: Cell reports, 22111247, 2022, ISSN 2211-1247
Publisher: Cell Press
DOI: 10.1016/j.celrep.2022.111105

Fat Induces Glucose Metabolism in Nontransformed Liver Cells and Promotes Liver Tumorigenesis

Author(s): Lindsay A. Broadfield, João André Gonçalves Duarte, Roberta Schmieder, Dorien Broekaert, Koen Veys, Mélanie Planque, Kim Vriens, Yasuaki Karasawa, Francesco Napolitano, Suguru Fujita, Masashi Fujii, Miki Eto, Bryan Holvoet, Roman Vangoitsenhoven, Juan Fernandez-Garcia, Joke Van Elsen, Jonas Dehairs, Jia Zeng, James Dooley, Rebeca Alba Rubio, Jos van Pelt, Thomas G.P. Grünewald, Adrian Liston,
Published in: Cancer Research, 81/8, 2021, Page(s) 1988-2001, ISSN 0008-5472
Publisher: American Association for Cancer Research
DOI: 10.1158/0008-5472.can-20-1954

PHGDH heterogeneity potentiates cancer cell dissemination and metastasis

Author(s): Rossi M, Altea-Manzano P, Demicco M, Doglioni G, Bornes L, Fukano M, Vandekeere A, Cuadros AM, Fernandez-Garcia J, Riera-Domingo C, Jauset C, Planque M, Alkan HF, Nittner D, Zuo D, Broadfield LA, Parik S, Pane AA, Rizzollo F, Rinaldi G, Zhang T, Teoh ST, Aurora AB, Karras P, Vermeire I, Broekaert D, Van Elsen J, Knott MML, Orth MF, Demeyer S, Eelen G, Dobrolecki LE, Bassez A, Van Brussel T, Sotlar
Published in: Nature, 00280836, 2022, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-022-04758-2

Serine metabolism remodeling after platinum-based chemotherapy identifies vulnerabilities in a subgroup of resistant ovarian cancers

Author(s): Tom Van Nyen, Mélanie Planque, Lilian van Wagensveld, Joao A. G. Duarte, Esther A. Zaal, Ali Talebi, Matteo Rossi, Pierre-René Körner, Lara Rizzotto, Stijn Moens, Wout De Wispelaere, Regina E. M. Baiden-Amissah, Gabe S. Sonke, Hugo M. Horlings, Guy Eelen, Emanuele Berardi, Johannes V. Swinnen, Celia R. Berkers, Peter Carmeliet, Diether Lambrechts, Ben Davidson, Reuven Agami, Sarah-Maria Fendt,
Published in: Nature Communications, 20411723, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-32272-6

In Crystallo Screening for Proline Analog Inhibitors of the Proline Cycle Enzyme PYCR1

Author(s): Emily M. Christensen, Alexandra N. Bogner, Anke Vandekeere, Gabriela S. Tam, Sagar M. Patel, Donald F. Becker, Sarah-Maria Fendt, John J. Tanner
Published in: Journal of Biological Chemistry, 2020, Page(s) jbc.RA120.016106, ISSN 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology Inc.
DOI: 10.1074/jbc.ra120.016106

GBM tumors are heterogeneous in their fatty acid metabolism and modulating fatty acid metabolism sensitizes cancer cells derived from recurring GBM tumors to temozolomidefmetas

Author(s): Sweta Parik, Juan Fernández-García, Francesca Lodi, Karen De Vlaminck, Marleen Derweduwe, Steven De Vleeschouwer, Raf Sciot, Wietse Geens, Linqian Weng, Francesca Maria Bosisio, Gabriele Bergers, Johnny Duerinck, Frederick De Smet, Diether Lambrechts, Jo A. Van Ginderachter and Sarah-Maria Fendt
Published in: Frontiers in oncology, 2234943X, 2022, ISSN 2234-943X
Publisher: Frontiers Media S. A.
DOI: 10.3389/fonc.2022.988872

Dynamic ROS Regulation by TIGAR: Balancing Anti-cancer and Pro-metastasis Effects

Author(s): Sarah-Maria Fendt, Sophia Y. Lunt
Published in: Cancer Cell, 37/2, 2020, Page(s) 141-142, ISSN 1535-6108
Publisher: Cell Press
DOI: 10.1016/j.ccell.2020.01.009

Metabolic vulnerabilities of metastasizing cancer cells

Author(s): Sarah-Maria Fendt
Published in: BMC Biology, 17/1, 2019, ISSN 1741-7007
Publisher: BioMed Central
DOI: 10.1186/s12915-019-0672-2

Assessing the Impact of the Nutrient Microenvironment on the Metabolism of Effector CD8+ T Cells

Author(s): Juan Fernández-García, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, 1862, 2019, Page(s) 187-216, ISBN 978-1-4939-8768-9
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8769-6_14

Measuring In Vivo Tissue Metabolism Using 13C Glucose Infusions in Mice

Author(s): Dorien Broekaert, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, 1862, 2019, Page(s) 67-82, ISBN 978-1-4939-8768-9
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8769-6_5

13C Tracer Analysis and Metabolomics in 3D Cultured Cancer Cells

Author(s): Marit van Gorsel, Ilaria Elia, Sarah-Maria Fendt
Published in: Metabolic Signaling - Methods and Protocols, 1862, 2019, Page(s) 53-66, ISBN 978-1-4939-8768-9
Publisher: Springer New York
DOI: 10.1007/978-1-4939-8769-6_4