Spatiotemporal regulation of localization and replication of M. tuberculosis in human macrophages

Project Information

DynaMO_TB

Grant agreement ID: 772022

DOI

10.3030/772022

Project closed

EC signature date 30 January 2018

Start date 1 September 2018

End date 31 August 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 2 000 000,00

EU contribution

€ 2 000 000,00

Coordinated by

THE FRANCIS CRICK INSTITUTE LIMITED
United Kingdom

CORDIS provides links to public deliverables and publications of HORIZON projects.

Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (8)

High content quantitative imaging of Mycobacterium tuberculosis responses to acidic microenvironments within human macrophages.

Author(s): Beren Aylan; Laure Botella; Maximiliano G. Gutierrez; Pierre Santucci
Published in: Crossref, Issue 1, 2022, ISSN 2211-5463
Publisher: Elsevier BV
DOI: 10.1002/2211-5463.13537

Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis

Author(s): Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez
Published in: mBio, Issue 13, 2022, ISSN 2150-7511
Publisher: American Society for Microbiology
DOI: 10.1128/mbio.00117-22

ATG7 and ATG14 restrict cytosolic and phagosomal Mycobacterium tuberculosis replication in human macrophages

Author(s): Beren Aylan, Elliott M. Bernard, Enrica Pellegrino, Laure Botella, Antony Fearns, Natalia Athanasiadi, Claudio Bussi, Pierre Santucci, Maximiliano G. Gutierrez
Published in: Nature Microbiology, Issue 8, 2024, Page(s) 803-818, ISSN 2058-5276
Publisher: Springer Science and Business Media LLC
DOI: 10.1038/s41564-023-01335-9

One size does not fit all: Lysosomes exist in biochemically and functionally distinct states

Author(s): Claudio Bussi, Maximiliano G. Gutierrez
Published in: PLOS Biology, Issue 22, 2024, Page(s) e3002576, ISSN 1545-7885
Publisher: Public Library of Science (PLoS)
DOI: 10.1371/journal.pbio.3002576

Stress granules plug and stabilize damaged endolysosomal membranes

Author(s): Claudio Bussi, Agustín Mangiarotti, Christian Vanhille-Campos, Beren Aylan, Enrica Pellegrino, Natalia Athanasiadi, Antony Fearns, Angela Rodgers, Titus M. Franzmann, Anđela Šarić, Rumiana Dimova, Maximiliano G. Gutierrez
Published in: Nature, Issue 623, 2023, Page(s) 1062-1069, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06726-w

Lysosomal damage drives mitochondrial proteome remodelling and reprograms macrophage immunometabolism

Author(s): Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott M. Bernard, Nourdine Bah, Mariana Silva Dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James I. MacRae, Maria Greco, Thomas Reinheckel, Matthias Trost & Maximiliano G. Gutierrez
Published in: Nature Communications, 2022, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-022-34632-8

Peroxisomal ROS control cytosolic <i>Mycobacterium tuberculosis</i> replication in human macrophages

Author(s): Enrica Pellegrino, Beren Aylan, Claudio Bussi, Antony Fearns, Elliott M. Bernard, Natalia Athanasiadi, Pierre Santucci, Laure Botella, Maximiliano G. Gutierrez
Published in: Journal of Cell Biology, Issue 222, 2023, ISSN 0021-9525
Publisher: Rockefeller University Press
DOI: 10.1083/jcb.202303066

<i>Mycobacterium tuberculosis</i> phagosome Ca ²⁺ leakage triggers multimembrane ATG8/LC3 lipidation to restrict damage in human macrophages

Author(s): Di Chen, Antony Fearns, Maximiliano G. Gutierrez
Published in: Science Advances, Issue 11, 2025, ISSN 2375-2548
Publisher: American Association for the Advancement of Science (AAAS)
DOI: 10.1126/sciadv.adt3311

Non-peer reviewed articles (3)

M. tuberculosis infection of human iPSC-derived macrophages reveals complex membrane dynamics during xenophagy evasion

Author(s): Elliott M. Bernard, Antony Fearns, Claudio Bussi, Pierre Santucci, Christopher J. Peddie, Rachel J. Lai, Lucy M. Collinson, Maximiliano G. Gutierrez
Published in: Journal of Cell Science, Issue 134/5, 2021, ISSN 0021-9533
Publisher: The Company of Biologists Ltd.
DOI: 10.1242/jcs.252973

Human stem cell‐based models for studying host‐pathogen interactions

Author(s): Enrica Pellegrino, Maximiliano G. Gutierrez
Published in: Cellular Microbiology, 2021, ISSN 1462-5814
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cmi.13335

Mycobacterium tuberculosis infection of host cells in space and time

Author(s): Claudio Bussi, Maximiliano G Gutierrez
Published in: FEMS Microbiology Reviews, Issue 43/4, 2019, Page(s) 341-361, ISSN 1574-6976
Publisher: Oxford University Press
DOI: 10.1093/femsre/fuz006

Conference proceedings (1)

The metabolic response of human macrophages to Mycobacterium tuberculosis infection

Author(s): C Bussi, M Silva Dos Santos, E M Bernard, P Santucci, J I Macrae, M G Gutierrez
Published in: 10.02 - Tuberculosis, 2020, Page(s) 65
Publisher: European Respiratory Society
DOI: 10.1183/23120541.lsc-2020.65