Discovery and molecular investigation of mycobacterial transporters responsible for iron acquisition

Project Information

MycoRailway

Grant agreement ID: 772190

DOI 10.3030/772190

Project closed

EC signature date 6 March 2018

Start date 1 April 2018

End date 31 March 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost € 1 999 865,00

EU contribution € 1 999 865,00

Coordinated by

UNIVERSITAT ZURICH
Switzerland

Publications

Peer reviewed articles (7)

The structure of the Legionella response regulator LqsR reveals amino acids critical for phosphorylation and dimerization.

Author(s): Ramon Hochstrasser; Cedric A. J. Hutter; Fabian M. Arnold; Kevin Bärlocher; Markus A. Seeger; Hubert Hilbi
Published in: Molecular Microbiology, Issue 1, 2020, ISSN 0950-382X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/mmi.14477

Structural basis for triacylglyceride extraction from mycobacterial inner membrane by MFS transporter Rv1410

Author(s): Sille Remm, Dario De Vecchis, Jendrik Schöppe, Cedric A J Hutter, Imre Gonda , Michael Hohl, Simon Newstead, Lars V Schäfer, Markus A Seeger
Published in: Nature Communicatons, 2023, ISSN 2041-1723
Publisher: Nature Publishing Group
DOI: 10.1038/s41467-023-42073-0

Critical discussion on drug efflux in Mycobacterium tuberculosis.

Author(s): Sille Remm; J.C. Earp; Thomas Dick; Véronique Dartois; Markus A. Seeger
Published in: FEMS Microbiology Reviews, Issue 2, 2022, ISSN 0168-6445
Publisher: Blackwell
DOI: 10.1093/femsre/fuab050

Mycobacterium marinum produces distinct mycobactin and carboxymycobactin siderophores to promote growth in broth and phagocytes

Author(s): Paulina Knobloch, Hendrik Koliwer‐Brandl, Fabian M. Arnold, Nabil Hanna, Imre Gonda, Sophia Adenau, Nicolas Personnic, Caroline Barisch, Markus A. Seeger, Thierry Soldati, Hubert Hilbi
Published in: Cellular Microbiology, Issue 22/5, 2020, ISSN 1462-5814
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/cmi.13163

The ABC exporter IrtAB imports and reduces mycobacterial siderophores

Author(s): Fabian M. Arnold, Miriam S. Weber, Imre Gonda, Marc J. Gallenito, Sophia Adenau, Pascal Egloff, Iwan Zimmermann, Cedric A. J. Hutter, Lea M. Hürlimann, Eike E. Peters, Jörn Piel, Gabriele Meloni, Ohad Medalia, Markus A. Seeger
Published in: Nature, Issue 580/7803, 2020, Page(s) 413-417, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-020-2136-9

Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG

Author(s): Michael Hohl, Sille Remm, Haig A. Eskandarian, Michael Dal Molin, Fabian M. Arnold, Lea M. Hürlimann, Andri Krügel, Georg E. Fantner, Peter Sander, Markus A. Seeger
Published in: Molecular Microbiology, Issue 111/5, 2019, Page(s) 1263-1282, ISSN 0950-382X
Publisher: Blackwell Publishing Inc.
DOI: 10.1111/mmi.14220

Structures of ABC transporters: handle with care.

Author(s): Lewinson, Oded; Orelle, Cédric; Seeger, Markus A
Published in: FEBS Letters, Issue 1, 2020, ISSN 0014-5793
Publisher: Elsevier BV
DOI: 10.1002/1873-3468.13966