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Mechanochemistry: a unique opportunity for oxygen isotopic labelling and NMR spectroscopy

Objective

Oxygen is an element of major importance, due to its presence in the vast majority of molecules and materials. Over the years, much effort has been put into the development of analytical techniques allowing the study of oxygen environments, in view of elucidating key questions about the structure and reactivity of a variety of systems. In this context, Nuclear Magnetic Resonance (NMR) spectroscopy has been the focus of much attention, because it has progressively emerged as a technique capable of providing deep insight into the local structure around this atom. However, NMR spectroscopy is highly challenging for oxygen, mainly because the NMR-active isotope, oxygen-17, has a very low natural abundance (0.04%), and hence a very poor sensitivity. Because of this, the majority of 17O NMR studies require enriching the molecules and materials of interest in 17O. Unfortunately, 17O-labelling is simply unaffordable at the moment for most research groups, meaning that 17O NMR spectroscopy is inaccessible to the broad community, and still considered as an “exotic” tool of analysis.
In this ERC project, the goal is to develop new rapid, user-friendly, and low-cost protocols for enriching a wide variety of organic and inorganic compounds in 17O by using mechanosynthesis. This original approach will then be taken as a unique opportunity (i) to push the current boundaries of 17O solid state NMR spectroscopy (by developing new tools for studying the structure of complex molecular and materials systems), and (ii) to elucidate major questions which could not be addressed so far, especially concerning reaction mechanisms between solids and the structure of interfaces of biological relevance.
In doing so, the overall idea is to make 17O NMR spectroscopy become a more standard analytical tool used by a vast research community, including chemists, biologists and physicists.

Fields of science (EuroSciVoc)

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Keywords

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Programme(s)

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Topic(s)

Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.

Funding Scheme

Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.

ERC-COG - Consolidator Grant

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Call for proposal

Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.

(opens in new window) ERC-2017-COG

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Host institution

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
Net EU contribution

Net EU financial contribution. The sum of money that the participant receives, deducted by the EU contribution to its linked third party. It considers the distribution of the EU financial contribution between direct beneficiaries of the project and other types of participants, like third-party participants.

€ 1 999 836,00
Address
RUE MICHEL ANGE 3
75794 PARIS
France

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Region
Ile-de-France Ile-de-France Paris
Activity type
Research Organisations
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Total cost

The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.

€ 1 999 836,00

Beneficiaries (1)

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