Lewis acid promoted copper catalysis to functionalise and dearomatise arenes

Project Information

LACOPAROM

Grant agreement ID: 773264

DOI

10.3030/773264

Project closed

EC signature date 19 January 2018

Start date 1 September 2018

End date 30 November 2024

Funded under

• EXCELLENT SCIENCE - European Research Council (ERC)

Total cost

€ 1 999 398,00

EU contribution

€ 1 999 398,00

Coordinated by

RIJKSUNIVERSITEIT GRONINGEN
Netherlands

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Links to deliverables and publications from FP7 projects, as well as links to some specific result types such as dataset and software, are dynamically retrieved from OpenAIRE .

Publications

Peer reviewed articles (19)

Electrophilic Trapping of Semibenzenes

Author(s): Cosimo Boldrini; Marta Castiñeira Reis; Syuzanna R. Harutyunyan
Published in: VOLUME=87;ISSUE=19;STARTPAGE=12772;ENDPAGE=12782;ISSN=0022-3263;TITLE=Journal of Organic Chemistry, Issue 1, 2022, ISSN 0022-3263
Publisher: American Chemical Society
DOI: 10.1021/acs.joc.2c01331

Unveiling New Reactivities in Complex Mixtures: Synthesis of Tricyclic Pyridinium Derivatives

Author(s): Johanan Kootstra, Jaya Mehara, Marieke J. Veenstra, Maëlle Le Cacheux, Luca E. Oddone, Aleksandr Y. Pereverzev, Janaa Roithová, Syuzanna R. Harutyunyan
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 5132-5139, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c15196

Manganese(I)-Catalyzed Asymmetric Hydrophosphination of α,β-Unsaturated Carbonyl Derivatives

Author(s): Roxana Postolache; Juana M. Pérez; Marta Castiñeira Reis; Luo Ge; Esther G. Sinnema; Syuzanna R. Harutyunyan
Published in: VOLUME=25;ISSUE=10;STARTPAGE=1611;ENDPAGE=1615;ISSN=1523-7060;TITLE=Organic letters, Issue 1, 2023, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.2c04256

Catalytic Access to 4-(sec-Alkyl)Anilines via 1,6-Conjugate Addition of Grignard Reagents to in Situ Generated aza- p-Quinone Methides

Author(s): Mercedes Zurro; Luo Ge; Syuzanna R. Harutyunyan
Published in: VOLUME=24;ISSUE=36;STARTPAGE=6686;ENDPAGE=6691;ISSN=1523-7060;TITLE=Organic letters, Issue 1, 2022, ISSN 1523-7060
Publisher: American Chemical Society
DOI: 10.1021/acs.orglett.2c02786

Enantio- and Z-selective synthesis of functionalized alkenes bearing tertiary allylic stereogenic center

Author(s): Luo Ge, Esther G. Sinnema, Juana M. Pérez, Roxana Postolache, Marta Castiñeira Reis and Syuzanna R. Harutyunyan
Published in: Science Advances, 2023, ISSN 2375-2548
Publisher: American Association for the Advancement of Science
DOI: 10.1126/sciadv.adf8742

Grignard Reagent Addition to Pyridinium Salts: A Catalytic Approach to Chiral 1,4-Dihydropyridines

Author(s): Siriphong Somprasong, Marta Castiñeira Reis, Syuzanna R. Harutyunyan
Published in: ACS Catalysis, Issue 14, 2024, Page(s) 13030-13039, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.4c03520

Catalytic Access to Chiral Lactams via Nucleophilic Dearomatisations of Pyridine Derivatives

Author(s): Siriphong Somprasong, Marta Castiñeira Reis and Syuzanna R. Harutyunyan
Published in: Angewandte Chemie International Edition, 2023, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202217328

Lewis Acid Promoted Dearomatization of Naphthols

Author(s): Kirill Kulish, Cosimo Boldrini, Marta Castiñeira Reis, Juana M. Pérez, Syuzanna R. Harutyunyan
Published in: Chemistry – A European Journal, Issue 26/68, 2020, Page(s) 15843-15846, ISSN 0947-6539
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/chem.202003392

Manganese(I)-Catalyzed H-P Bond Activation via Metal-Ligand Cooperation

Author(s): Juana M. Pérez; Roxana Postolache; Marta Castiñeira Reis; Esther G Sinnema; Denisa Vargová; Folkert de Vries; Edwin Otten; Luo Ge; Syuzanna R. Harutyunyan
Published in: Journal of the American Chemical Society, Issue 5, 2021, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.1c10756

Enantioselective nickel-catalyzed electrochemical reductive conjugate alkenylation of α,β-unsaturated ketones

Author(s): Siriphong Somprasong, Bin Wan, Syuzanna R. Harutyunyan
Published in: Chemical Science, Issue 16, 2025, Page(s) 802-808, ISSN 2041-6520
Publisher: Royal Society of Chemistry
DOI: 10.1039/d4sc06891b

Manganese(I)‐Catalyzed Access to Enantioenriched Chiral Aziridine Phosphines

Author(s): Chuang Ni, Tizian‐Frank Ramspoth, Marta Castiñeira Reis, Syuzanna R. Harutyunyan
Published in: Angewandte Chemie International Edition, Issue 64, 2025, ISSN 1433-7851
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/anie.202415623

Manganese(I)-catalyzed access to 1,2-bisphosphine ligands

Author(s): Luo Ge; Syuzanna R. Harutyunyan
Published in: Chemical Science, 13(5), 1307 - 1312. ROYAL SOC CHEMISTRY, Issue 1, 2022, ISSN 2041-6539
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1sc06694c

Copper-catalysed alkylation of heterocyclic acceptors with organometallic reagents

Author(s): Yafei Guo, Syuzanna R Harutyunyan
Published in: Beilstein Journal of Organic Chemistry, Issue 16, 2020, Page(s) 1006-1021, ISSN 1860-5397
Publisher: Beilstein-Institut
DOI: 10.3762/bjoc.16.90

Pd-catalyzed allylative dearomatisation using Grignard reagents

Author(s): Cosimo Boldrini; Syuzanna R. Harutyunyan
Published in: Chemical Communications, 57(89), 11807 - 11810. ROYAL SOC CHEMISTRY, Issue 1, 2021, ISSN 1364-548X
Publisher: Royal Society of Chemistry
DOI: 10.1039/d1cc05609c

Manganese(I)-Catalyzed Enantioselective Alkylation To Access P-Stereogenic Phosphines

Author(s): Bin Wan, Marta Castiñeira Reis, Tizian-Frank Ramspoth, Syuzanna R. Harutyunyan
Published in: Journal of the American Chemical Society, Issue 147, 2025, Page(s) 3740-3746, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.4c16130

Highly Enantioselective Catalytic Addition of Grignard Reagents to N‐Heterocyclic Acceptors

Author(s): Yafei Guo, Syuzanna R. Harutyunyan
Published in: Angewandte Chemie, Issue 131/37, 2019, Page(s) 13084-13088, ISSN 0044-8249
Publisher: John Wiley & Sons Ltd.
DOI: 10.1002/ange.201906237

Nucleophilic Dearomatization of N-Heteroaromatics Enabled by Lewis Acids and Copper Catalysis

Author(s): Xingchen Yan, Luo Ge, Marta Castiñeira Reis, Syuzanna R. Harutyunyan
Published in: Journal of the American Chemical Society, Issue 142/47, 2020, Page(s) 20247-20256, ISSN 0002-7863
Publisher: American Chemical Society
DOI: 10.1021/jacs.0c09974

A catalytically active oscillator made from small organic molecules

Author(s): Matthijs ter Harmsel, Oliver R. Maguire, Sofiya A. Runikhina, Albert S. Y. Wong, Wilhelm T. S. Huck, Syuzanna R. Harutyunyan
Published in: Nature, Issue 621, 2023, Page(s) 87-93, ISSN 0028-0836
Publisher: Nature Publishing Group
DOI: 10.1038/s41586-023-06310-2

Enantioselective Catalytic Dearomative Addition of Grignard Reagents to 4-Methoxypyridinium Ions

Author(s): Yafei Guo, Marta Castiñeira Reis, Johanan Kootstra, Syuzanna R. Harutyunyan
Published in: ACS Catalysis, Issue 11/14, 2021, Page(s) 8476-8483, ISSN 2155-5435
Publisher: American Chemical Society
DOI: 10.1021/acscatal.1c01544