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Personalised Medicine by Predictive Modeling in Stroke for better Quality of Life

Periodic Reporting for period 2 - PRECISE4Q (Personalised Medicine by Predictive Modeling in Stroke for better Quality of Life)

Reporting period: 2019-11-01 to 2021-04-30

Stroke is one of the most severe medical problems with far-reaching public health and socio-economic impact, gathering momentum in an ageing society. Over the course of four years, PRECISE4Q sets out to minimise the burden of stroke for the individual and for society. It will create multi-dimensional data-driven predictive simulation computer models enabling – for the first time – personalised stroke treatment, addressing patient’s needs in four stages: prevention, acute treatment, rehabilitation and reintegration.

* Heterogeneous data from multidisciplinary sources will be integrated: genomics, microbiomics, biochemical; imaging including mechanistic biophysiological models of brain perfusion/function; social, lifestyle, gender; economic and worklife, requiring substantial efforts for information extraction, semantic labelling and standardisation.
* Novel hybrid model architectures, structured prediction models, complex deep-learning and gradient boosting models will form the Digital Stroke Patient Platform including a Stroke Risk CDSS (Clinical Decision Support System), Treatment Outcomes CDSS, Rehab Programme, Socio-Economic Planning Tool and New QvidLab.
* The decision support will be tailored to the patient's current life stage thus enabling clinicians to optimise prevention and treatment strategies over time, and will include personalised coping strategies, support of well-being and reintegration into social life and work.
* The predictive capability and clinical precision will be validated with real clinical data generated by (i) prospective clinical studies and (ii) retrospective analyses of big data sets: health registries, cohort studies, health insurance data, electronic health records.
PRECISE4Q will have a clinically measurable and sustainable impact leading to better understanding of risk, health and resilience factors. In contrast to current schematic therapy guidelines, it will support patients throughout their lifelong journey by personalised strategies for their specific needs.
* In a value-based pricing system, PRECISE4Q, once implemented, could generate massive reductions in direct and indirect health care costs as personalised prevention, treatment, rehabilitation programmes and reintegration will lead to fewer cases of stroke, better procedures, better outcomes for patients and higher return to work rates, respectively. Learn more about the project's goals and work plan below.
Work has been performed across all work packages. A task-by-task description is presented in the periodic report (technical report Part B).
PRECISE4Q provides true personalized predictive modelling in stroke. To this end, we innovate by developing (1) novel hybrid model architectures, (2) novel complex models (including deep-learning and gradient boosting models) capable of (3) feature ranking to inform novel intervention design, (4) scaling to high-dimensional data and big-data and integrating different forms of input data (both image and structured), and (5) predicting complex interrelated and consistent structures using multi-task learning and structure prediction methods.