Different glycan assay formats will be tested for integration into microfluidic platform.
Data-driven models will be derived by applying MLPCA to the datasets to determine the data-driven required number of pseudo-bioreactions. In a second step, a decision on the kinetic structure (grey-box vs black-box) will be taken with respect to the data content. Eventually, an adapted identification procedure will be applied and validated with the datasets.
The algorithms of outlier detection, noise reduction and smoothing are implemented and validated. Furthermore preprocessing procedures like deviation-, distance- and density-based approaches are implemented in the evaluation program.
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Author(s): Sebastian Giehring
Published in: Animal Cell Biotechnology - Methods and Protocols, Issue 2095, 2020, Page(s) 271-284