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Integrated control and sensing platform for biopharmaceutical cultivation process high-throughput development and production

Deliverables

Off-line glycosylation/titre assays after sample purification/preparation on fluidic platform

Different glycan assay formats will be tested for integration into microfluidic platform.

Spectral pre-processing procedures (such as outlier detection, noise reduction and smoothing) are implemented

The algorithms of outlier detection, noise reduction and smoothing are implemented and validated. Furthermore preprocessing procedures like deviation-, distance- and density-based approaches are implemented in the evaluation program.

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Publications

High-Throughput Quantification and Glycosylation Analysis of Antibodies Using Bead-Based Assays

Author(s): Sebastian Giehring
Published in: Animal Cell Biotechnology - Methods and Protocols, Issue 2095, 2020, Page(s) 271-284
DOI: 10.1007/978-1-0716-0191-4_15