Deliverables Documents, reports (10) Biocompatibility reports Biocompatibility reports Micro/nanospheres, nanostructured materials, membranes and hydrogels with tailored physicochemical properties Micronanospheres nanostructured materials membranes and hydrogels with tailored physicochemical properties Public Engagement plan Public Engagement plan Multifunctional scaffold Multifunctional scaffold Blends and composites of selected materials Blends and composites of selected materials Safety and toxicity tests Safety and toxicity tests Fabrication and characterization of natural biomaterial scaffolds Fabrication and characterization of natural biomaterial scaffolds Methods and procedures for biological evaluation of scaffolds Methods and procedures for biological evaluation of scaffolds Natural origin materials , with different physicochemical properties and of different origin Natural origin materials (polysaccharides, proteins, ceramics), with different physicochemical properties and of different origin, suitable for the development of multifunctional biomaterials Methods to differentiate mouse mesenchymal stem cells (MSC) Methods to differentiate mouse mesenchymal stem cells MSC Websites, patent fillings, videos etc. (1) Communication protocols and website setup Communication protocols and website setup Publications Peer reviewed articles (26) A biocompatible and injectable hydrogel to boost the efficacy of stem cells in neurodegenerative diseases treatment. Author(s): Helena Ferreira; Diana Amorim; Ana Cláudia Lima; Rogério P. Pirraco; Ana R. Costa-Pinto; Rui Almeida; Armando Almeida; Rui L. Reis; Filipa Pinto-Ribeiro; Nuno M. Neves Published in: Life Sciences, Issue 1, 2021, Page(s) 10, ISSN 0024-3205 Publisher: Elsevier BV DOI: 10.1016/j.lfs.2021.120108 Exploring the Gelation Mechanisms and Cytocompatibility of Gold (III)-Mediated Regenerated and Thiolated Silk Fibroin Hydrogels Author(s): Chavee Laomeephol, Helena Ferreira, Supansa Yodmuang, Rui L. Reis, Siriporn Damrongsakkul, Nuno M. Neves Published in: Biomolecules, Issue 10/3, 2020, Page(s) 466, ISSN 2218-273X Publisher: Biomolecules DOI: 10.3390/biom10030466 Adhesive and antibacterial films based on marine-derived fucoidan and chitosan Author(s): Correia, C.; Costa, Diana Pereira Soares; Inácio, A. R.; Vale, A. C.; Peixoto, D.; Silva, Tiago H.; Reis, R. L.; Pashkuleva, I.; Alves, N. M. Published in: ACS Sustainable Chemistry & Engineering, Issue 6, 2022, Page(s) 10, ISSN 2168-0485 Publisher: American Chemical Society DOI: 10.1021/acssuschemeng.2c05144 Glutathione Reductase-Sensitive Polymeric Micelles for Controlled Drug Delivery on Arthritic Diseases. Author(s): Ana Cláudia Lima; Rui L. Reis; Helena Lage Ferreira; Nuno M. Neves Published in: ACS Biomater. Sci. Eng., Issue 8, 2021, Page(s) 13, ISSN 2373-9878 Publisher: ACS Publications DOI: 10.1021/acsbiomaterials.1c00412 Adhesive and Antibacterial Films Based on Marine-Derived Fucoidan and Chitosan Author(s): Cátia Correia; Diana Soares da Costa; Ana Rita Inácio; A. Catarina Vale; Daniela Peixoto; Tiago H. Silva; Rui L. Reis; Iva Pashkuleva; Natália M. Alves Published in: ACS Sustainable Chemistry & Engineering, Issue 1, 2022, ISSN 2168-0485 Publisher: American Chemical Society DOI: 10.1021/acssuschemeng.2c05144 A genipin crosslinked silk fibroin monolith by compression molding with recovering mechanical properties in physiological conditions Author(s): Alessio Bucciarelli; Valentino Janigro; Yuejiao Yang; Giulia Fredi; Alessandro Pegoretti; Antonella Motta; Devid Maniglio Published in: Cell Reports Physical Science, Issue 4, 2021, Page(s) 10, ISSN 2666-3864 Publisher: Cell Press DOI: 10.1016/j.xcrp.2021.100605 Biofunctionalized Liposomes to Monitor Rheumatoid Arthritis Regression Stimulated by Interleukin‐23 Neutralization Author(s): Ana Cláudia Lima, Cláudia F. Campos, Cristina Cunha, Agostinho Carvalho, Rui L. Reis, Helena Ferreira, Nuno M. Neves Published in: Advanced Healthcare Materials, Issue 10/2, 2021, Page(s) 2001570, ISSN 2192-2640 Publisher: John Wiley and Sons Ltd DOI: 10.1002/adhm.202001570 Modulating inflammation through the neutralization of Interleukin-6 and tumor necrosis factor-α by biofunctionalized nanoparticles. Author(s): Ana Cláudia Lima; Diana Amorim; Inês Laranjeira; Armando Almeida; Rui L. Reis; Helena Lage Ferreira; Filipa Pinto-Ribeiro; Nuno M. Neves Published in: reponame:Repositório Científico de Acesso Aberto de Portugal, Issue 2, 2021, ISSN 0168-3659 Publisher: Elsevier BV DOI: 10.1016/j.jconrel.2021.02.001 A Bio-inspired Multifunctionalized Silk Fibroin Author(s): Sofia Santi, Ines Mancini, Sandra Dirè, Emanuela Callone, Giorgio Speranza, Nicola Pugno, Claudio Migliaresi, Antonella Motta Published in: ACS Biomaterials Science & Engineering, Issue 7/2, 2021, Page(s) 507-516, ISSN 2373-9878 Publisher: ACS Biomaterials DOI: 10.1021/acsbiomaterials.0c01567 Anti-Inflammatory Properties of Injectable Betamethasone-Loaded Tyramine-Modified Gellan Gum/Silk Fibroin Hydrogels Author(s): Isabel Matos Oliveira, Cristiana Gonçalves, Myeong Eun Shin, Sumi Lee, Rui Luis Reis, Gilson Khang, Joaquim Miguel Oliveira Published in: Biomolecules, Issue 10/10, 2020, Page(s) 1456, ISSN 2218-273X Publisher: Biomolecules DOI: 10.3390/biom10101456 Biomedical applications of silk and its role for intervertebral disc repair Author(s): Andreas S. Croft, Eugenia Spessot, Promita Bhattacharjee, Yuejiao Yang, Antonella Motta, Michael Wöltje, Benjamin Gantenbein Published in: JOR Spine, Issue 3, 2022, Page(s) 18, ISSN 2572-1143 Publisher: Wiley DOI: 10.1002/jsp2.1225 Enzymatically crosslinked tyramine-gellan gum hydrogels as drug delivery system for rheumatoid arthritis treatment Author(s): Isabel Matos Oliveira, Cristiana Gonçalves, Myeong Eun Shin, Sumi Lee, Rui L. Reis, Gilson Khang, Joaquim Miguel Oliveira Published in: Drug Delivery and Translational Research, 2020, ISSN 2190-393X Publisher: Springer Pub. Co., DOI: 10.1007/s13346-020-00855-9 Dual-functional liposomes for curcumin delivery and accelerating silk fibroin hydrogel formation Author(s): Chavee Laomeephol, Helena Ferreira, Sorada Kanokpanont, Nuno M. Neves, Hisatoshi Kobayashi, Siriporn Damrongsakkul Published in: International Journal of Pharmaceutics, Issue 589, 2020, Page(s) 119844, ISSN 0378-5173 Publisher: Elsevier BV DOI: 10.1016/j.ijpharm.2020.119844 Osteogenic differentiation of encapsulated cells in dexamethasone-loaded phospholipid-induced silk fibroin hydrogels Author(s): Laomeephol, C., Ferreira, H., Kanokpanont, S., Luckanagul, J., Neves, N., & Damrongsakkul, S. Published in: Biomaterials Translational, Issue 3, 2022, Page(s) 7, ISSN 2096-112X Publisher: Chinese Medical Association DOI: 10.12336/biomatertransl.2022.03.005 Processing keratin from camel hair and cashmere with ionic liquids Author(s): Y. J. Yang, D. Ganbat, P. Aramwit, A. Bucciarelli, J. Chen, C. Migliaresi, A. Motta Published in: Express Polymer Letters, Issue 13/2, 2019, Page(s) 97-108, ISSN 1788-618X Publisher: Budapesti Muszaki Egyetem, Department of Polymer Engineering DOI: 10.3144/expresspolymlett.2019.10 Spider (Linothele megatheloides) and silkworm (Bombyx mori) silks: Comparative physical and biological evaluation Author(s): Yuejiao Yang, Gabriele Greco, Devid Maniglio, Barbara Mazzolai, Claudio Migliaresi, Nicola Pugno, Antonella Motta Published in: Materials Science and Engineering: C, Issue September 13th, 2019, 2019, Page(s) 110197, ISSN 0928-4931 Publisher: Elsevier BV DOI: 10.1016/j.msec.2019.110197 Layer‐by‐layer films based on catechol‐modified polysaccharides produced by dip‐ and spin‐coating onto different substrates Author(s): Ana C. Almeida, Ana C. Vale, Ricardo A. Pires, Rui L. Reis, Natália M. Alves Published in: Journal of Biomedical Materials Research Part B: Applied Biomaterials, Issue 2019, 2019, Page(s) 1-16, ISSN 1552-4973 Publisher: John Wiley & Sons Inc. DOI: 10.1002/jbm.b.34489 Phospholipid‐induced silk fibroin hydrogels and their potential as cell carriers for tissue regeneration Author(s): Chavee Laomeephol, Marta Guedes, Helena Ferreira, Rui L. Reis, Sorada Kanokpanont, Siriporn Damrongsakkul, Nuno M. Neves Published in: Journal of Tissue Engineering and Regenerative Medicine, Issue 31 October 2019, 2019, ISSN 1932-6254 Publisher: John Wiley & Sons Ltd. DOI: 10.1002/term.2982 A novel and selective silk fibroin fragmentation method. Author(s): Francesca Agostinacchio; Devid Maniglio; Emanuela Callone; Claudio Migliaresi; Sandra Dirè; Antonella Motta Published in: Soft matter, Issue 6, 2021, Page(s) 10, ISSN 1744-683X Publisher: Royal Society of Chemistry DOI: 10.1039/d1sm00566a 3D printing of PCL/nano-hydroxyapatite scaffolds derived from biogenic sources for bone tissue engineering Author(s): Francesca Cestari; Mauro Petretta; Yuejiao Yang; Antonella Motta; Brunella Grigolo; Vincenzo M. Sglavo Published in: Sustainable Materials and Technologies, Issue 6, 2021, Page(s) 10, ISSN 2214-9937 Publisher: Elsevier DOI: 10.1016/j.susmat.2021.e00318 Preparation and Statistical Characterization of Tunable Porous Sponge Scaffolds using UV Cross-linking of Methacrylate-Modified Silk Fibroin Author(s): Alessio Bucciarelli; Alessio Bucciarelli; Thangavelu Muthukumar; Jin Su Kim; Won Kyung Kim; Alberto Quaranta; Devid Maniglio; Gilson Khang; Antonella Motta Published in: ACS Biomater. Sci. Eng, Issue 7, 2019, Page(s) 14, ISSN 2373-9878 Publisher: ACSPublications DOI: 10.1021/acsbiomaterials.9b00814 Amphiphilic copolymers in biomedical applications: Synthesis routes and property control Author(s): Francesca Perin, Antonella Motta, Devid Maniglio Published in: Materials Science and Engineering: C, Issue 123, 2021, Page(s) 111952, ISSN 0928-4931 Publisher: Elsevier BV DOI: 10.1016/j.msec.2021.111952 A Design of Experiment Rational Optimization of the Degumming Process and Its Impact on the Silk Fibroin Properties Author(s): Alessio Bucciarelli; Gabriele H. Greco; Ilaria Corridori; Nicola M. Pugno; Nicola M. Pugno; Antonella Motta; Antonella Motta Published in: ACS Biomater. Sci. Eng., Issue 3, 2021, Page(s) 19, ISSN 2373-9878 Publisher: Acs publications DOI: 10.1021/acsbiomaterials.0c01657 Cellular Uptake of Three Different Nanoparticles in an Inflammatory Arthritis Scenario versus Normal Conditions Author(s): Ana Cláudia Lima; Rui L. Reis; Helena Ferreira; Nuno M. Neves Published in: Mol. Pharmaceutics, Issue 6, 2021, Page(s) 12, ISSN 2373-9878 Publisher: ACS Publications DOI: 10.1021/acs.molpharmaceut.1c00066 Modulating inflammation through the neutralization of Interleukin-6 and tumor necrosis factor-α by biofunctionalized nanoparticles Author(s): Ana Cláudia Lima, Diana Amorim, Inês Laranjeira, Armando Almeida, Rui L. Reis, Helena Ferreira, Filipa Pinto-Ribeiro, Nuno M. Neves Published in: Journal of Controlled Release, Issue 331, 2021, Page(s) 491-502, ISSN 0168-3659 Publisher: Elsevier BV DOI: 10.1016/j.jconrel.2021.02.001 Bioactive and adhesive properties of multilayered coatings based on catechol-functionalized chitosan/hyaluronic acid and bioactive glass nanoparticles Author(s): Ana Catarina Almeida, Ana Catarina Vale, Rui L. Reis, Natália M. Alves Published in: International Journal of Biological Macromolecules, Issue 157, 2020, Page(s) 119-134, ISSN 0141-8130 Publisher: Elsevier BV DOI: 10.1016/j.ijbiomac.2020.04.095 Book chapters (1) Biomaterials as ECM-like matrices for 3D in vitro tumor models Author(s): Lara Pierantoni; Joana Silva-Correia; Antonella Motta; Rui L. Reis; Joaquim M. Oliveira Published in: Biomaterials for 3D Tumor Modeling ISBN: 9780128181287, Issue 6, 2020, Page(s) 16, ISBN 9780128181287 Publisher: Elsevier DOI: 10.1016/b978-0-12-818128-7.00007-1 Searching for OpenAIRE data... There was an error trying to search data from OpenAIRE No results available
