Objective
The high incidence of larvae skeletal deformities is a significant problem in European marine aquaculture. This problem has a serious impact on the industry's productivity, on product quality and on animal welfare. The factors, which may cause skeletal anomalies in fish are largely unstudied, although in tetrapods there is ample evidence that PTHrP plays a significant role in both normal and abnormal development and growth of the skeleton. Preliminary studies carried out by the CME group indicate that PTHrP may be implicated in skeletal deformities, which arise as a consequence of altered chondrogenesis and calcification.
Thus, the fundamental scientific objective of this project is to investigate the importance of the unique hypercalcemic factor identified in fish, PTHrP, in endochondral bone development and its application as a possible marker for skeletal anomalies in fish. This will be achieved through the application of recombinant DNA and gene transfer technology as a tool for the induction of PTHrP gene over expression in fish embryos. The present project programme will therefore aim to establish unequivocally the role of PTHrP in chondrogenesis and skeletal development and link this to skeletal abnormalities. Several objectives have been identified which will contribute to the overall achievement of the aim.
Firstly, obtention of PTHrP expression construct and its microinjection into fertilized fish eggs; Secondly, assessment the ectopic expression of PTHrP in notochord cells of fish embryos and finally, evaluation the influence of PTHrP in the development of axial skeleton. Moreover, additional objectives of this research proposal are to promote the scientific development of the applicant and transfer the technology and knowledge acquired at the host institute during the visit to USA to the CME group at the return host institute. This will be important for the development of these groups' objectives but will also benefit the whole academic community.
Fields of science (EuroSciVoc)
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
CORDIS classifies projects with EuroSciVoc, a multilingual taxonomy of fields of science, through a semi-automatic process based on NLP techniques. See: The European Science Vocabulary.
- agricultural sciences agriculture, forestry, and fisheries fisheries
- medical and health sciences medical biotechnology genetic engineering gene therapy
- natural sciences biological sciences genetics DNA
- social sciences economics and business economics production economics productivity
- medical and health sciences clinical medicine embryology
You need to log in or register to use this function
Programme(s)
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Multi-annual funding programmes that define the EU’s priorities for research and innovation.
Topic(s)
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Calls for proposals are divided into topics. A topic defines a specific subject or area for which applicants can submit proposals. The description of a topic comprises its specific scope and the expected impact of the funded project.
Call for proposal
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
Procedure for inviting applicants to submit project proposals, with the aim of receiving EU funding.
FP6-2002-MOBILITY-6
See other projects for this call
Funding Scheme
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
Funding scheme (or “Type of Action”) inside a programme with common features. It specifies: the scope of what is funded; the reimbursement rate; specific evaluation criteria to qualify for funding; and the use of simplified forms of costs like lump sums.
OIF - Marie Curie actions-Outgoing International Fellowships
Coordinator
FARO
Portugal
The total costs incurred by this organisation to participate in the project, including direct and indirect costs. This amount is a subset of the overall project budget.