Periodic Reporting for period 4 - RECAGE (How to best meet the needs of people with dementia with severe behavioural disturbances. Toward a respectful and cost-effective model)
Reporting period: 2022-07-01 to 2023-06-30
A. To start a prospective cohort study, comparing the activity of the centres endowed with a SCU-B (Gazzaniga, Modena, Ottestad, Genève, Mannheim) with that of the other centres lacking this structure (Thessaloniki, Mantova, Bergamo, Perugia, Paris, Berlin). The study will allow us:
• to assess the short and long-term clinical effectiveness of SCU-B on BPSD
• to measure the changes of the quality of life of the PwD/carers over time
• to explore if the SCU-B is effective in delaying institutionalisation
• to explore the cost-effectiveness of the SCU-B
• to evaluate the ethical aspects of care in the SCU-B (e.g. attitude of the staff/relatives of PwD)
B. To adapt the model in accordance with the results of the cohort study, not only regarding the main endpoints, but also comparing the experience and the different ways to work of the participating centres and the different socio-political context in which they act
C. To scale up the intervention in the countries who take part in the study, but where SCU-B are absent or sporadic as Italy and Greece.
• Preparation of a detailed protocol and manual of operation (Task 1.1)
• Preparation of Informed Consent Form in national languages (Task 1.1)
• Approval of Ethics Review Committees of the coordinating centre and enrolling institutions (Task 1.1)
• Design and development of the eCRF (Task 1.2)
• Organisation of web-based training sessions for the eCRF users (Task 1.2)
• Inclusion of 518 patients (out of 500 planned total) into the RECAGE study (Task 2.1)
• Completion of the 24 M visit by 263 patients until 12.12.2020 (Task 2.2)
• Release of the first complete version of the Statistical Analysis Plan (WP3)
• Release of the Data Management Plan (Task 6.3)
• Release of the Interim Statistical Report (MS8, WP2, WP3)
• Completion of Focus Groups for the qualitative study (WP4) and starting ti write a paper for publication
• Completion of the questionnaire on the structure of clinical centers (Task 4.1)
Furthermore, several results have been obtained in the frame of dissemination and communication of project results. In details:
• Creation of a project communication and dissemination plan
• Development of a project logo
• Setup, maintenance and regular update of a project website
• Creation of a project leaflet
• Setup, maintenance and regular update of a Facebook page
• Implementation of more than 50 communication, dissemination and awareness raising activities towards the different stakeholders (such as clinicians, patients, caregivers and general public) using a variety of dissemination tools (conferences, speeches, newsletters, TV Shows, social media activities)
• Definition of Exploitation and Sustainability Plan
• Presentation of several Posters or report to International Conferences (Annual conference of the Italian association of Geriatrics 2018; Alzheimer Disease International Conference 2022; Alzheimer Europe international conferences 2020, 2022 and 2023; Alzheimer’s Association International Conference 2021; Annual conference of the Italian Association of Psychogeriatrics 2019 and 2022)
Presentation of project results to the stakeholders of the Emilia Romagna Region (RER), Italy (9 June 2023)
However, since the clinical trial did not confirm our hypothesis, either as regards long-term clinical effectiveness or cost-efficiency, even though some evidence of clinical effectiveness in the acute phase were found in the literature and in our post-hoc analysis, we were unable to recommend the implementation of new units if not in an experimental way and possibly in a randomized study versus another king of intervention, for instance the mobile BPSD teams.
Anyway, the comparison among existing models in different European countries, the analysis of their effectiveness and economical sustainability, the attention to the ethical aspects of this condition, discussed by a group of experts in dialogue with representatives of the public, allowed us to work out a set of recommendations for establishing and running a SCU-B that were discussed in a Consensus Conference, which took place in February 2023 and reached international consensus about the structure and functions of a typical SCU-B. Moreover, already before knowing the trial, we had plan for establishing some pilot units in Italy and Greece. Our efforts succeeded in Italy, allowing the creation of a new SCU-in a rehab hospital.